Aspartate Aminotransferase (AST)
[Edit]cCAT; AAT; ASAT; SGOT; GOT1; Cysteine transaminase, cytoplasmic; Transaminase A; Aspartate Transaminase 1,Cytoplasmic; Glutamic-Oxaloacetic Transaminase 1,Soluble
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AST) is similar to alanine transaminase (ALT) in that it is another enzyme associated with liver parenchymal cells.It is raised in acute liver damage. It is also present in red blood cells and cardiac muscle, skeletal muscle, and kidney and brain tissue, and may be elevated due to damage to those sources as well.AST was defined as a biochemical marker for the diagnosis of acute myocardial infarction in 1954. However the use of AST for such a diagnosis is now redundant and has been superseded by the cardiac troponins.
The 2 isoenzymes are homodimeric. In liver about 80% of the enzyme activity is mitochondrial in origin, whereas in serum the enzyme activity is largely cytosolic.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB214Ra01 | Recombinant Aspartate Aminotransferase (AST) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAB214Ra01 | Polyclonal Antibody to Aspartate Aminotransferase (AST) | WB; IHC; ICC; IP. |
| LAB214Ra71 | Biotin-Linked Polyclonal Antibody to Aspartate Aminotransferase (AST) | WB; IHC; ICC. | |
| MAB214Ra21 | Monoclonal Antibody to Aspartate Aminotransferase (AST) | WB; IHC; ICC; IP. | |
| MAB214Ra22 | Monoclonal Antibody to Aspartate Aminotransferase (AST) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB214Ra | ELISA Kit for Aspartate Aminotransferase (AST) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Oryctolagus cuniculus (Rabbit)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Aspartate Aminotransferase (AST) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Aspartate Aminotransferase (AST) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Aspartate Aminotransferase (AST) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | SEB214Rb | ELISA Kit for Aspartate Aminotransferase (AST) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Sus scrofa; Porcine (Pig)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Aspartate Aminotransferase (AST) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Aspartate Aminotransferase (AST) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Aspartate Aminotransferase (AST) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | SEB214Po | ELISA Kit for Aspartate Aminotransferase (AST) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Bos taurus; Bovine (Cattle)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB214Bo01 | Recombinant Aspartate Aminotransferase (AST) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAB214Bo01 | Polyclonal Antibody to Aspartate Aminotransferase (AST) | WB; IHC; ICC; IP. |
| MAB214Bo21 | Monoclonal Antibody to Aspartate Aminotransferase (AST) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB214Bo | ELISA Kit for Aspartate Aminotransferase (AST) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Chicken (Gallus)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Aspartate Aminotransferase (AST) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Aspartate Aminotransferase (AST) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Aspartate Aminotransferase (AST) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Aspartate Aminotransferase (AST) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Aspartate Aminotransferase (AST) | ELISA Kit Customized Service Offer |
- "Properties of human liver cytosolic aspartate aminotransferase mRNAs generated by alternative polyadenylation site selection."Biochemistry 29:5293-5299(1990) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "The amino acid sequence of cytosolic aspartate aminotransferase from human liver."Biochem. J. 270:651-657(1990) [PubMed] [Europe PMC] [Abstract]
- "Amino acids and transaminases activity in ventricular CSF and in brain of normal and Alzheimer patients."Neurosci. Lett. 388:49-53(2005) [PubMed] [Europe PMC] [Abstract]
- "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
- "Genome-wide association study identifies genetic variants in GOT1 determining serum aspartate aminotransferase levels."J. Hum. Genet. 56:801-805(2011) [PubMed] [Europe PMC] [Abstract]
- "Relationship between glutamate, GOT and GPT levels in maternal and fetal blood: a potential mechanism for fetal neuroprotection."Early Hum. Dev. 88:773-778(2012) [PubMed] [Europe PMC] [Abstract]
- "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
- "Crystal structure of human glutamate oxaloacetate transaminase 1 (GOT1)."Submitted (AUG-2009) to the PDB data bank