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Signaling Lymphocytic Activation Molecule Family, Member 5 (SLAMF5)

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CD84; LY9B; Cell surface antigen MAX.3; Hly9-beta; Leukocyte differentiation antigen CD84

Signaling Lymphocytic Activation Molecule Family, Member 5 (SLAMF5)
CCC B155
HGNC 1704
MGI 1336885
PubMed 23064403
RGD 1564553
UniProt Q9UIB8
Wiki CD84

CD84 encodes a 328-amino acid protein that is shortened to 307 amino acids after cleavage of the signal peptide. The protein has 4 potential N-linked and 29 potential O-linked glycosylation sites. The observed molecular mass on SDS-PAGE is 64 to 82 kD, which endoglycosidase treatment reduces to 46 kD and 36 kD products, close to the calculated mass of approximately 35 kD. In addition to a 25-amino acid transmembrane region and an 83-amino acid cytoplasmic region, CD84 has a 189-amino acid extracellular segment composed of 2 Ig-like domains similar to that found in other members of the CD2 family. Northern blot analysis revealed mRNA expression of a 4.4-kb transcript at high levels in lymphoid tissue and at lower levels in lung; no expression was found in liver.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB155Hu01 Recombinant Signaling Lymphocytic Activation Molecule Family, Member 5 (SLAMF5) Positive Control; Immunogen; SDS-PAGE; WB.
RPB155Hu02 Recombinant Signaling Lymphocytic Activation Molecule Family, Member 5 (SLAMF5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB155Hu01 Polyclonal Antibody to Signaling Lymphocytic Activation Molecule Family, Member 5 (SLAMF5) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Signaling Lymphocytic Activation Molecule Family, Member 5 (SLAMF5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Signaling Lymphocytic Activation Molecule Family, Member 5 (SLAMF5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB155Mu01 Recombinant Signaling Lymphocytic Activation Molecule Family, Member 5 (SLAMF5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB155Mu01 Polyclonal Antibody to Signaling Lymphocytic Activation Molecule Family, Member 5 (SLAMF5) WB; IHC; ICC; IP.
Assay Kits SEB155Mu ELISA Kit for Signaling Lymphocytic Activation Molecule Family, Member 5 (SLAMF5) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Signaling Lymphocytic Activation Molecule Family, Member 5 (SLAMF5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Signaling Lymphocytic Activation Molecule Family, Member 5 (SLAMF5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Signaling Lymphocytic Activation Molecule Family, Member 5 (SLAMF5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Signaling Lymphocytic Activation Molecule Family, Member 5 (SLAMF5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Signaling Lymphocytic Activation Molecule Family, Member 5 (SLAMF5) ELISA Kit Customized Service Offer
  1. "CD84 leukocyte antigen is a new member of the Ig superfamily."Blood 90:2398-2405(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of MAX.3 antigen, a glycoprotein expressed on mature macrophages, dendritic cells and blood platelets: identity with CD84."Biochem. J. 346:729-736(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Genomic characterization of CD84 reveals the existence of five isoforms differing in their cytoplasmic domains."Tissue Antigens 55:118-127(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP."Blood 97:3867-3874(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family."Clin. Immunol. 100:15-23(2001) [PubMed] [Europe PMC] [Abstract]
  10. "CD150 association with either the SH2-containing inositol phosphatase or the SH2-containing protein tyrosine phosphatase is regulated by the adaptor protein SH2D1A."J. Immunol. 166:5480-5487(2001) [PubMed] [Europe PMC] [Abstract]
  11. "CD84 functions as a homophilic adhesion molecule and enhances IFN-gamma secretion: adhesion is mediated by Ig-like domain 1."J. Immunol. 167:3668-3676(2001) [PubMed] [Europe PMC] [Abstract]
  12. "CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2."Eur. J. Immunol. 32:1640-1649(2002) [PubMed] [Europe PMC] [Abstract]
  13. "Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation."J. Immunol. 171:2485-2495(2003) [PubMed] [Europe PMC] [Abstract]
  14. "CD84 expression on human hematopoietic progenitor cells."Exp. Hematol. 31:798-805(2003) [PubMed] [Europe PMC] [Abstract]
  15. "Differential expression of SAP and EAT-2-binding leukocyte cell-surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (2B4)."Tissue Antigens 64:132-144(2004) [PubMed] [Europe PMC] [Abstract]
  16. "Platelet aggregation induces platelet aggregate stability via SLAM family receptor signaling."Blood 106:3028-3034(2005) [PubMed] [Europe PMC] [Abstract]
  17. "Structure of CD84 provides insight into SLAM family function."Proc. Natl. Acad. Sci. U.S.A. 104:10583-10588(2007) [PubMed] [Europe PMC] [Abstract]