≡

Fibrinogen Alpha Chain (FGA)

[Edit]

Fib2; FG-A; FGA; Fibrinopeptide A

Fibrinogen Alpha Chain (FGA)
CCC B154
HGNC 3661
MGI 1316726
PubMed 12492584
RGD 2603
UniProt P02671
Wiki FGA

Fibrinogen alpha chain is the alpha component of fibrinogen, a blood-borne glycoprotein composed of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots.

In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in the carboxy-terminus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB154Hu01 Recombinant Fibrinogen Alpha Chain (FGA) Positive Control; Immunogen; SDS-PAGE; WB.
RPB154Hu02 Recombinant Fibrinogen Alpha Chain (FGA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB154Hu01 Polyclonal Antibody to Fibrinogen Alpha Chain (FGA) WB; ICC; IHC-P; IHC-F; ELISA.
MAB154Hu22 Monoclonal Antibody to Fibrinogen Alpha Chain (FGA) WB; IHC; ICC; IP.
LAB154Hu71 Biotin-Linked Polyclonal Antibody to Fibrinogen Alpha Chain (FGA) WB; IHC; ICC.
LAB154Hu81 FITC-Linked Polyclonal Antibody to Fibrinogen Alpha Chain (FGA) WB; IHC; ICC; IF.
Assay Kits SEB154Hu ELISA Kit for Fibrinogen Alpha Chain (FGA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB154Mu01 Recombinant Fibrinogen Alpha Chain (FGA) Positive Control; Immunogen; SDS-PAGE; WB.
RPB154Mu02 Recombinant Fibrinogen Alpha Chain (FGA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB154Mu01 Polyclonal Antibody to Fibrinogen Alpha Chain (FGA) WB; IHC; ICC; IP.
LAB154Mu71 Biotin-Linked Polyclonal Antibody to Fibrinogen Alpha Chain (FGA) WB; IHC; ICC.
PAB154Mu02 Polyclonal Antibody to Fibrinogen Alpha Chain (FGA) WB; IHC; ICC; IP.
Assay Kits SEB154Mu ELISA Kit for Fibrinogen Alpha Chain (FGA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB154Ra01 Recombinant Fibrinogen Alpha Chain (FGA) Positive Control; Immunogen; SDS-PAGE; WB.
RPB154Ra02 Recombinant Fibrinogen Alpha Chain (FGA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB154Ra01 Polyclonal Antibody to Fibrinogen Alpha Chain (FGA) WB; IHC; ICC; IP.
PAB154Ra02 Polyclonal Antibody to Fibrinogen Alpha Chain (FGA) WB; IHC; ICC; IP.
LAB154Ra71 Biotin-Linked Polyclonal Antibody to Fibrinogen Alpha Chain (FGA) WB; IHC; ICC.
LAB154Ra81 FITC-Linked Polyclonal Antibody to Fibrinogen Alpha Chain (FGA) WB; IHC; ICC; IF.
MAB154Ra21 Monoclonal Antibody to Fibrinogen Alpha Chain (FGA) WB; IHC; ICC; IP.
MAB154Ra22 Monoclonal Antibody to Fibrinogen Alpha Chain (FGA) WB; IHC; ICC; IP.
Assay Kits SEB154Ra ELISA Kit for Fibrinogen Alpha Chain (FGA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fibrinogen Alpha Chain (FGA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fibrinogen Alpha Chain (FGA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fibrinogen Alpha Chain (FGA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fibrinogen Alpha Chain (FGA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fibrinogen Alpha Chain (FGA) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB154Bo01 Recombinant Fibrinogen Alpha Chain (FGA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB154Bo01 Polyclonal Antibody to Fibrinogen Alpha Chain (FGA) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Fibrinogen Alpha Chain (FGA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fibrinogen Alpha Chain (FGA) ELISA Kit Customized Service Offer
  1. "Carboxy-terminal-extended variant of the human fibrinogen alpha subunit: a novel exon conferring marked homology to beta and gamma subunits."Biochemistry 31:11968-11972(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Fibrinogen DNA and protein sequences."(In) Ebert R.F. (eds.);Index of variant human fibrinogens, pp.13-24, CRC Press, Boca Raton (1994)
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Nucleotide sequences of the three genes coding for human fibrinogen."Adv. Exp. Med. Biol. 281:39-48(1990) [PubMed] [Europe PMC] [Abstract]
  6. "Partial mRNA sequences for human A alpha, B beta, and gamma fibrinogen chains: evolutionary and functional implications."Proc. Natl. Acad. Sci. U.S.A. 80:3953-3957(1983) [PubMed] [Europe PMC] [Abstract]
  7. "Characterization of a complementary deoxyribonucleic acid coding for the alpha chain of human fibrinogen."Biochemistry 22:3237-3244(1983) [PubMed] [Europe PMC] [Abstract]
  8. "Human fibrinogen: sequence, sulfur bridges, glycosylation and some structural variants."(In) Peeters H. (eds.);Protides of the biological fluids, Proc. 28th colloquium, pp.51-56, Pergamon Press, Oxford (1980)
  9. "Amino acid sequence studies on the alpha chain of human fibrinogen. Overlapping sequences providing the complete sequence."Biochemistry 18:5410-5416(1979) [PubMed] [Europe PMC] [Abstract]
  10. "Isolation and characterisation of cDNA clones for the A alpha- and gamma-chains of human fibrinogen."Nucleic Acids Res. 11:7427-7434(1983) [PubMed] [Europe PMC] [Abstract]
  11. "Cloning of fibrinogen genes and their cDNA."Ann. N. Y. Acad. Sci. 408:449-456(1983) [PubMed] [Europe PMC] [Abstract]
  12. "Studies on fibrinopeptides from primates."Acta Chem. Scand. 19:1788-1789(1965)
  13. "Amino acid sequence studies on the alpha chain of human fibrinogen. Exact location of cross-linking acceptor sites."Biochemistry 18:5405-5410(1979) [PubMed] [Europe PMC] [Abstract]
  14. "Localization of the alpha-chain cross-link acceptor sites of human fibrin."J. Biol. Chem. 253:2184-2195(1978) [PubMed] [Europe PMC] [Abstract]
  15. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  16. "Disulfide bridges in NH2-terminal part of human fibrinogen."Thromb. Res. 8:639-658(1976) [PubMed] [Europe PMC] [Abstract]
  17. "Fibrinogen and fibrin."Annu. Rev. Biochem. 53:195-229(1984) [PubMed] [Europe PMC] [Abstract]
  18. "Cross-linking site in fibrinogen for alpha 2-plasmin inhibitor."J. Biol. Chem. 261:15591-15595(1986) [PubMed] [Europe PMC] [Abstract]
  19. "Phosphorylation of fibrinogen by casein kinase 1."Biochem. Biophys. Res. Commun. 117:631-636(1983) [PubMed] [Europe PMC] [Abstract]
  20. "Phosphoproteomic analysis of the human pituitary."Pituitary 9:109-120(2006) [PubMed] [Europe PMC] [Abstract]
  21. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  22. "Prolyl 4-hydroxylation of alpha-fibrinogen: a novel protein modification revealed by plasma proteomics." J. Biol. Chem. 284:29041-29049(2009) [PubMed] [Europe PMC] [Abstract]
  23. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  24. "A unique proteolytic fragment of human fibrinogen containing the A alpha COOH-terminal domain of the native molecule."J. Biol. Chem. 265:13669-13676(1990) [PubMed] [Europe PMC] [Abstract]
  25. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  26. "Glycoproteomic analysis of human fibrinogen reveals novel regions of O-glycosylation."J. Proteome Res. 11:5804-5814(2012) [PubMed] [Europe PMC] [Abstract]
  27. "Characterization of fibrinogen glycosylation and its importance for serum/plasma N-glycome analysis."J. Proteome Res. 12:444-454(2013) [PubMed] [Europe PMC] [Abstract]
  28. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  29. "The structure of residues 7-16 of the A alpha-chain of human fibrinogen bound to bovine thrombin at 2.3-A resolution."J. Biol. Chem. 267:7911-7920(1992) [PubMed] [Europe PMC] [Abstract]
  30. "Crystal structures of fragment D from human fibrinogen and its crosslinked counterpart from fibrin."Nature 389:455-462(1997) [PubMed] [Europe PMC] [Abstract]
  31. "Crystal structure of fragment double-D from human fibrin with two different bound ligands."Biochemistry 37:8637-8642(1998) [PubMed] [Europe PMC] [Abstract]
  32. "Crystal structure of a recombinant alphaEC domain from human fibrinogen-420."Proc. Natl. Acad. Sci. U.S.A. 95:9099-9104(1998) [PubMed] [Europe PMC] [Abstract]
  33. "Conformational changes in fragments D and double-D from human fibrin(ogen) upon binding the peptide ligand Gly-His-Arg-Pro-amide."Biochemistry 38:2941-2946(1999) [PubMed] [Europe PMC] [Abstract]
  34. "Fibrinogen Kyoto II, a new congenitally abnormal molecule, characterized by the replacement of A alpha proline-18 by leucine."Blood 78:149-153(1991) [PubMed] [Europe PMC] [Abstract]
  35. "Fibrinogen Lima: a homozygous dysfibrinogen with an A alpha-arginine-141 to serine substitution associated with extra N-glycosylation at A alpha-asparagine-139. Impaired fibrin gel formation but normal fibrin-facilitated plasminogen activation catalyzed by tissue-type plasminogen activator."J. Clin. Invest. 90:67-76(1992) [PubMed] [Europe PMC] [Abstract]
  36. "An A alpha Ser-434 to N-glycosylated Asn substitution in a dysfibrinogen, fibrinogen Caracas II, characterized by impaired fibrin gel formation."J. Biol. Chem. 266:11575-11581(1991) [PubMed] [Europe PMC] [Abstract]
  37. "Molecular basis for fibrinogen Dusart (A alpha 554 Arg-->Cys) and its association with abnormal fibrin polymerization and thrombophilia."J. Clin. Invest. 91:1637-1643(1993) [PubMed] [Europe PMC] [Abstract]
  38. "Hereditary renal amyloidosis associated with a mutant fibrinogen alpha-chain."Nat. Genet. 3:252-255(1993) [PubMed] [Europe PMC] [Abstract]
  39. "Fibrinogen Osaka IV: a congenital dysfibrinogenemia found in a patient originally reported in relation to surgery, now defined to have an A alpha arginine-16 to histidine substitution."Surg. Today 23:45-50(1993) [PubMed] [Europe PMC] [Abstract]
  40. "Aberrant hepatic processing causes removal of activation peptide and primary polymerisation site from fibrinogen Canterbury (A-alpha 20 Val-to-Asp)."J. Clin. Invest. 96:2854-2858(1995) [PubMed] [Europe PMC] [Abstract]
  41. "Characterization of single-nucleotide polymorphisms in coding regions of human genes."Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
  42. ErratumNat. Genet. 23:373-373(1999)
  43. "The fibrinogen Aalpha R16C mutation results in fibrinolytic resistance."Br. J. Haematol. 134:220-226(2006) [PubMed] [Europe PMC] [Abstract]
  44. "Clinical and molecular characterisation of 21 patients affected by quantitative fibrinogen deficiency."Thromb. Haemost. 113:567-576(2015) [PubMed] [Europe PMC] [Abstract]