Mitogen Activated Protein Kinase Kinase Kinase Kinase 5 (MAP4K5)

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MAP4-K5; GCKR; KHS; KHS1; MAPKKKK5; Germinal Center Kinase-Related; Kinase homologous to SPS1/STE20

Mitogen Activated Protein Kinase Kinase Kinase Kinase 5 (MAP4K5)

Mitogen-activated protein kinase kinase kinase kinase 5 is a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response.

Northern blot analysis detected a 4.5-kb MAP4K5 transcript in all tissues tested, namely spleen, thymus, prostate, testis, ovary, small intestine, colon, and peripheral blood leukocytes. SDS-PAGE and immunoblot analyses determined that MAP4K5 is expressed as a 95-kD protein. Confocal laser microscopy demonstrated cytoplasmic expression of MAP4K5.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB135Hu01 Recombinant Mitogen Activated Protein Kinase Kinase Kinase Kinase 5 (MAP4K5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB135Hu01 Polyclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase Kinase 5 (MAP4K5) WB; ICC; IHC-P; IHC-F; ELISA.
Assay Kits SEB135Hu ELISA Kit for Mitogen Activated Protein Kinase Kinase Kinase Kinase 5 (MAP4K5) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB135Mu01 Recombinant Mitogen Activated Protein Kinase Kinase Kinase Kinase 5 (MAP4K5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB135Mu01 Polyclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase Kinase 5 (MAP4K5) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase Kinase Kinase Kinase 5 (MAP4K5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase Kinase Kinase Kinase 5 (MAP4K5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitogen Activated Protein Kinase Kinase Kinase Kinase 5 (MAP4K5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase Kinase 5 (MAP4K5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase Kinase 5 (MAP4K5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase Kinase Kinase Kinase 5 (MAP4K5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase Kinase Kinase Kinase 5 (MAP4K5) ELISA Kit Customized Service Offer
  1. "A novel human SPS1/STE20 homologue, KHS, activates jun N-terminal kinase."Oncogene 14:653-659(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins."Oncogene 17:1893-1901(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  5. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  6. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]