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Chemokine C-C-Motif Ligand 16 (CCL16)

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SCYA16; SCYL4; LEC; HCC4; LMC; LCC1; CKb12; Mtn1; CC-4; Monotactin-1; IL-10-inducible chemokine; Liver-expressed chemokine; Lymphocyte and monocyte chemoattractant

Chemokine C-C-Motif Ligand 16 (CCL16)
CCC B126
HGNC 10614
PubMed 21951809
UniProt O15467
Wiki CCL16

Chemokine (C-C motif) ligand 16 (CCL16) is a small cytokine belonging to the CC chemokine family that is known under several pseudonyms, including Liver-expressed chemokine (LEC) and Monotactin-1 (MTN-1). This chemokine is expressed by the liver, thymus, and spleen and is chemoattractive for monocytes and lymphocytes. Liver-expressed chemokine (LEC)/CCL16 is a human CC chemokine selectively expressed in the liver.

Cellular expression of CCL16 can be strongly induced in monocytes by IL-10, IFN-γ and bacterial lipopolysaccharide. Its gene is located on chromosome 17, in humans, among a cluster of other CC chemokines. CCL16 elicits its effects on cells by interacting with cell surface chemokine receptors such as CCR1, CCR2, CCR5 and CCR8.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB126Hu01 Recombinant Chemokine C-C-Motif Ligand 16 (CCL16) Positive Control; Immunogen; SDS-PAGE; WB.
EPB126Hu51 Eukaryotic Chemokine C-C-Motif Ligand 16 (CCL16) Positive Control; Immunogen; SDS-PAGE; WB.
RPB126Hu02 Recombinant Chemokine C-C-Motif Ligand 16 (CCL16) Positive Control; Immunogen; SDS-PAGE; WB.
APB126Hu01 Active Chemokine C-C-Motif Ligand 16 (CCL16) Cell culture; Activity Assays.
Antibodies PAB126Hu01 Polyclonal Antibody to Chemokine C-C-Motif Ligand 16 (CCL16) WB; IHC; ICC; IP.
LAB126Hu71 Biotin-Linked Polyclonal Antibody to Chemokine C-C-Motif Ligand 16 (CCL16) WB; IHC; ICC.
PAB126Hu02 Polyclonal Antibody to Chemokine C-C-Motif Ligand 16 (CCL16) WB; IHC; ICC; IP.
PAB126Hu07 Polyclonal Antibody to Chemokine C-C-Motif Ligand 16 (CCL16) WB; IHC; ICC; IP.
Assay Kits SEB126Hu ELISA Kit for Chemokine C-C-Motif Ligand 16 (CCL16) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chemokine C-C-Motif Ligand 16 (CCL16) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chemokine C-C-Motif Ligand 16 (CCL16) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chemokine C-C-Motif Ligand 16 (CCL16) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chemokine C-C-Motif Ligand 16 (CCL16) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chemokine C-C-Motif Ligand 16 (CCL16) ELISA Kit Customized Service Offer
  1. "Characterization of a novel CC chemokine, HCC-4, whose expression is increased by interleukin-10."Blood 91:4242-4247(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation of cDNA encoding a novel human CC chemokine NCC-4/LEC."Biochim. Biophys. Acta 1396:273-277(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES."J. Interferon Cytokine Res. 19:227-234(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Isolation and characterization of LMC, a novel lymphocyte and monocyte chemoattractant human CC chemokine, with myelosuppressive activity."Biochem. Biophys. Res. Commun. 247:217-222(1998) [PubMed] [Europe PMC] [Abstract]
  5. "Genomic organization of the genes for human and mouse CC chemokine LEC."DNA Cell Biol. 18:275-283(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Cloning, characterization and genomic organization of LCC-1 (scya16), a novel human CC chemokine expressed in liver."Cytokine 12:101-109(2000) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]