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Myosin Light Chain Kinase (MYLK)

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KRP; MLCK108; MLCK210; MSTP083; MLCK; smMLCK; MYLK1; MLCK1; Telokin; Myosin Light Chain Kinase, Smooth Muscle, deglutamylated form; Kinase-related protein

Myosin Light Chain Kinase (MYLK)
CCC B106
HGNC 7590
MGI 894806
PubMed 11306802
RGD 1310915
UniProt Q15746
Wiki MYLK

Myosin light chain kinase, smooth muscle is a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity.

This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB106Hu01 Recombinant Myosin Light Chain Kinase (MYLK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB106Hu01 Polyclonal Antibody to Myosin Light Chain Kinase (MYLK) WB; IHC
MAB106Hu22 Monoclonal Antibody to Myosin Light Chain Kinase (MYLK) WB; IHC; ICC; IP.
Assay Kits SEB106Hu ELISA Kit for Myosin Light Chain Kinase (MYLK) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB106Mu01 Recombinant Myosin Light Chain Kinase (MYLK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB106Mu01 Polyclonal Antibody to Myosin Light Chain Kinase (MYLK) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Myosin Light Chain Kinase (MYLK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myosin Light Chain Kinase (MYLK) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB106Ra01 Recombinant Myosin Light Chain Kinase (MYLK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB106Ra01 Polyclonal Antibody to Myosin Light Chain Kinase (MYLK) WB; IHC; ICC; IP.
MAB106Ra21 Monoclonal Antibody to Myosin Light Chain Kinase (MYLK) WB; IHC; ICC; IP.
Assay Kits SEB106Ra ELISA Kit for Myosin Light Chain Kinase (MYLK) Enzyme-linked immunosorbent assay for Antigen Detection.
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  12. "Myosin light chain kinase modulates hypotonicity-induced Ca2+ entry and Cl- channel activity in human cervical cancer cells."Pflugers Arch. 444:276-285(2002) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative measurements of Ca(2+)/calmodulin binding and activation of myosin light chain kinase in cells."FEBS Lett. 557:121-124(2004) [PubMed] [Europe PMC] [Abstract]
  14. "Distinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure."Gastroenterology 128:987-1001(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Tumor necrosis factor-induced long myosin light chain kinase transcription is regulated by differentiation-dependent signaling events. Characterization of the human long myosin light chain kinase promoter."J. Biol. Chem. 281:26205-26215(2006) [PubMed] [Europe PMC] [Abstract]
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  20. "Nonmuscle myosin light-chain kinase mediates neutrophil transmigration in sepsis-induced lung inflammation by activating beta2 integrins."Nat. Immunol. 9:880-886(2008) [PubMed] [Europe PMC] [Abstract]
  21. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
  22. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  23. "Androgens down-regulate myosin light chain kinase in human prostate cancer cells."J. Steroid Biochem. Mol. Biol. 114:174-179(2009) [PubMed] [Europe PMC] [Abstract]
  24. "Arrest defective-1 controls tumor cell behavior by acetylating myosin light chain kinase."PLoS ONE 4:E7451-E7451(2009) [PubMed] [Europe PMC] [Abstract]
  25. "Myosin light chain kinase is responsible for high proliferative ability of breast cancer cells via anti-apoptosis involving p38 pathway."Acta Pharmacol. Sin. 31:725-732(2010) [PubMed] [Europe PMC] [Abstract]
  26. "Modulation of factors affecting optic nerve head astrocyte migration."Invest. Ophthalmol. Vis. Sci. 51:4096-4103(2010) [PubMed] [Europe PMC] [Abstract]
  27. "Quantitative distribution and colocalization of non-muscle myosin light chain kinase isoforms and cortactin in human lung endothelium."Microvasc. Res. 80:75-88(2010) [PubMed] [Europe PMC] [Abstract]
  28. "Abl tyrosine kinase phosphorylates nonmuscle Myosin light chain kinase to regulate endothelial barrier function."Mol. Biol. Cell 21:4042-4056(2010) [PubMed] [Europe PMC] [Abstract]
  29. "The angiotensin II type 1 receptor induces membrane blebbing by coupling to Rho A, Rho kinase, and myosin light chain kinase."Mol. Pharmacol. 77:903-911(2010) [PubMed] [Europe PMC] [Abstract]
  30. "Non-muscle myosin light chain kinase isoform is a viable molecular target in acute inflammatory lung injury."Am. J. Respir. Cell Mol. Biol. 44:40-52(2011) [PubMed] [Europe PMC] [Abstract]
  31. "Organometallic pyridylnaphthalimide complexes as protein kinase inhibitors."Organometallics 30:4598-4606(2011) [PubMed] [Europe PMC] [Abstract]
  32. "Myosin, transgelin, and myosin light chain kinase: expression and function in asthma."Am. J. Respir. Crit. Care Med. 179:194-204(2009) [PubMed] [Europe PMC] [Abstract]
  33. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
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  35. "Solution structure of the eighth Ig-like domain of human myosin light chain kinase."Submitted (NOV-2005) to the PDB data bank
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