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Myosin Light Chain 2 (MYL2)

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CMH10; MLC2; Myosin,Light Chain 2,Regulatory,Cardiac,Slow; Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Myosin Light Chain 2, Regulatory, Cardiac

Myosin Light Chain 2 (MYL2)
CCC B102
HGNC 7583
MGI 97272
PubMed 1386340
RGD 3141
UniProt P10916
Wiki MYL2

Myosin regulatory light chain 2, ventricular/cardiac muscle isoform is the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in MYL2 are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy.The 2 pairs of light chains of muscle myosins are called essential light chains (ELC) and regulatory light chains (RLC).

The light chains stabilize the long alpha helical neck of the myosin head. Myosin light chain-2 (MYL2) is an important protein in the regulation of myosin ATPase activity in smooth muscle. An increase in ventricular MYL2 is observed in the hypertrophied myocardium of cardiac patients with valvular stenosis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB102Hu01 Recombinant Myosin Light Chain 2 (MYL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB102Hu01 Polyclonal Antibody to Myosin Light Chain 2 (MYL2) WB; IHC; ICC; IP.
MAB102Hu22 Monoclonal Antibody to Myosin Light Chain 2 (MYL2) WB; IHC; ICC; IP.
Assay Kits SEB102Hu ELISA Kit for Myosin Light Chain 2 (MYL2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myosin Light Chain 2 (MYL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myosin Light Chain 2 (MYL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myosin Light Chain 2 (MYL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myosin Light Chain 2 (MYL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myosin Light Chain 2 (MYL2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myosin Light Chain 2 (MYL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myosin Light Chain 2 (MYL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myosin Light Chain 2 (MYL2) Polyclonal Antibody Customized Service Offer
Assay Kits SEB102Ra ELISA Kit for Myosin Light Chain 2 (MYL2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Isolation and nucleotide sequence of the cDNA encoding human ventricular myosin light chain 2."Nucleic Acids Res. 17:2360-2360(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Interaction of a conserved peptide domain in recombinant human ventricular myosin light chain-2 with myosin heavy chain."Cell. Mol. Biol. Res. 39:13-26(1993) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
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  7. "Identification of two novel mutations in the ventricular regulatory myosin light chain gene (MYL2) associated with familial and classical forms of hypertrophic cardiomyopathy."J. Mol. Med. 76:208-214(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Systematic analysis of the regulatory and essential myosin light chain genes: genetic variants and mutations in hypertrophic cardiomyopathy."Eur. J. Hum. Genet. 10:741-748(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Hypertrophic cardiomyopathy: distribution of disease genes, spectrum of mutations, and implications for a molecular diagnosis strategy."Circulation 107:2227-2232(2003) [PubMed] [Europe PMC] [Abstract]
  10. ErratumCirculation 109:3258-3258(2004)
  11. "Identification of the genotypes causing hypertrophic cardiomyopathy in northern Sweden."J. Mol. Cell. Cardiol. 35:841-849(2003) [PubMed] [Europe PMC] [Abstract]