Ubiquitin Conjugating Enzyme E2A (UBE2A)
[Edit]UBC2; HHR6A; RAD6 Homolog; Ubiquitin carrier protein A; Ubiquitin-protein ligase A
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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s.
As deduced from the pleiotropic phenotype of rad6 deletion mutants in Saccharomyces cerevisiae, the RAD6 protein plays an important role in various cellular processes. The protein is strongly conserved in eukaryotic evolution,UBE2A is a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Multiple alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB063Hu01 | Recombinant Ubiquitin Conjugating Enzyme E2A (UBE2A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPB063Hu02 | Recombinant Ubiquitin Conjugating Enzyme E2A (UBE2A) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAB063Hu01 | Polyclonal Antibody to Ubiquitin Conjugating Enzyme E2A (UBE2A) | WB; IHC; ICC; IP. |
| MAB063Hu22 | Monoclonal Antibody to Ubiquitin Conjugating Enzyme E2A (UBE2A) | WB; IHC; ICC; IP. | |
| Assay Kits | n/a | CLIA Kit for Ubiquitin Conjugating Enzyme E2A (UBE2A) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Ubiquitin Conjugating Enzyme E2A (UBE2A) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB063Mu01 | Recombinant Ubiquitin Conjugating Enzyme E2A (UBE2A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPB063Mu02 | Recombinant Ubiquitin Conjugating Enzyme E2A (UBE2A) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| RPB063Mu03 | Recombinant Ubiquitin Conjugating Enzyme E2A (UBE2A) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| RPB063Mu04 | Recombinant Ubiquitin Conjugating Enzyme E2A (UBE2A) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAB063Mu01 | Polyclonal Antibody to Ubiquitin Conjugating Enzyme E2A (UBE2A) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Ubiquitin Conjugating Enzyme E2A (UBE2A) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Ubiquitin Conjugating Enzyme E2A (UBE2A) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Ubiquitin Conjugating Enzyme E2A (UBE2A) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Ubiquitin Conjugating Enzyme E2A (UBE2A) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Ubiquitin Conjugating Enzyme E2A (UBE2A) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Ubiquitin Conjugating Enzyme E2A (UBE2A) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Ubiquitin Conjugating Enzyme E2A (UBE2A) | ELISA Kit Customized Service Offer |
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- "Phosphorylation by cyclin-dependent kinase-9 controls ubiquitin-conjugating enzyme-2A function."Cell Cycle 11:2122-2127(2012) [PubMed] [Europe PMC] [Abstract]
- "Novel missense mutations in the ubiquitination-related gene UBE2A cause a recognizable X-linked mental retardation syndrome."Clin. Genet. 77:541-551(2010) [PubMed] [Europe PMC] [Abstract]