Heat Shock 70kDa Protein 1 Like Protein (HSPA1L)

Heat shock 70 kDa protein 1L is a 70kDa heat shock protein. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which also encode isoforms of the 70kDa heat shock protein.The HSPA1L rs2075800 G allele frequency was higher in the sarcoid-uveitis group than in both the sarcoid-nonuveitis and control groups (83% vs 71%, OR, 2.00, P(c) = 0.01; and 83% vs 66%, OR, 2.45, P(c) = 0.00005, respectively). Similar results were observed when considering the carriage frequency of the associated haplotype (HSP70 haplotype 2) across the 3 study groups.