Cluster Of Differentiation 15 (CD15)

Twenty antibodies, all of which bound specifically to the surface of human myeloid cells, exhibited similar reactivity patterns with the hybrid clones. Chromosomal analysis showed that the gene or genes involved in expression of the 1 or more antigens recognized by these antibodies must be located on human chromosome 11q12-qter. This myeloid-associated surface antigen was designated CD15 in the CD system.Analysis of fetal tissues revealed abundant expression in liver, muscle, kidney, skin, and small intestine, and moderate expression in brain, lung, and heart. The transcript size varied in different tissues. In adult tissues, highest expression was found in lung and small intestine, low expression in kidney, liver, and brain, and no expression in 12 other tissues tested.