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Caspase Activated DNase (CAD)

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DFF-B; DFFB; CPAN; DFF40; DFF2; DNA Fragmentation Factor 40kDa Beta Polypeptide; Caspase-activated deoxyribonuclease; Caspase-activated nuclease

Caspase Activated DNase (CAD)
CCC B058
HGNC 2773
MGI 1196287
PubMed 9422506
RGD 620335
UniProt O76075
Wiki DFFB
DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase), also known as DFFB. Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB058Hu01 Recombinant Caspase Activated DNase (CAD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB058Hu01 Polyclonal Antibody to Caspase Activated DNase (CAD) WB; IHC; ICC; IP.
MAB058Hu22 Monoclonal Antibody to Caspase Activated DNase (CAD) WB; IHC; ICC; IP.
Assay Kits SEB058Hu ELISA Kit for Caspase Activated DNase (CAD) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Caspase Activated DNase (CAD) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Caspase Activated DNase (CAD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Caspase Activated DNase (CAD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Caspase Activated DNase (CAD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Caspase Activated DNase (CAD) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Caspase Activated DNase (CAD) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Caspase Activated DNase (CAD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Caspase Activated DNase (CAD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Caspase Activated DNase (CAD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Caspase Activated DNase (CAD) ELISA Kit Customized Service Offer
  1. "The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis."Proc. Natl. Acad. Sci. U.S.A. 95:8461-8466(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and characterization of human caspase-activated DNase."Proc. Natl. Acad. Sci. U.S.A. 95:9123-9128(1998) [PubMed] [Europe PMC] [Abstract]
  3. "CPAN, a human nuclease regulated by the caspase-sensitive inhibitor DFF45."Curr. Biol. 8:537-540(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Histone H1 subtype preferences of DFF40 and possible nuclear localization of DFF40/45 in normal and trichostatin A-treated NB4 leukemic cells."Apoptosis 15:128-138(2010) [PubMed] [Europe PMC] [Abstract]
  9. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  10. "Structure and mutation analysis of the gene encoding DNA fragmentation factor 40 (caspase-activated nuclease), a candidate neuroblastoma tumour suppressor gene."Hum. Genet. 106:406-413(2000) [PubMed] [Europe PMC] [Abstract]