Vimentin (VIM)
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Vimentin is a type III intermediate filament (IF) protein that is expressed in mesenchymal cells. IF proteins are found in all metazoan cells as well as bacteria. IF, along with tubulin-based microtubules and actin-based microfilaments, comprise the cytoskeleton. All IF proteins are expressed in a highly developmentally-regulated fashion; vimentin is the major cytoskeletal component of mesenchymal cells. Because of this, vimentin is often used as a marker of mesenchymally-derived cells or cells undergoing an epithelial-to-mesenchymal transition (EMT) during both normal development and metastatic progression. A vimentin monomer, like all other intermediate filaments, has a central α-helical domain, capped on each end by non-helical amino (head) and carboxyl (tail) domains.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB040Hu01 | Recombinant Vimentin (VIM) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPB040Hu02 | Recombinant Vimentin (VIM) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APB040Hu01 | Active Vimentin (VIM) | Cell culture; Activity Assays. | |
| EPB040Hu61 | Eukaryotic Vimentin (VIM) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| EPB040Hu62 | Eukaryotic Vimentin (VIM) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAB040Hu01 | Polyclonal Antibody to Vimentin (VIM) | WB; IHC; ICC/IF |
| MAB040Hu22 | Monoclonal Antibody to Vimentin (VIM) | WB; IHC; ICC/IF | |
| LAB040Hu71 | Biotin-Linked Polyclonal Antibody to Vimentin (VIM) | WB | |
| MAB040Hu24 | Monoclonal Antibody to Vimentin (VIM) | WB; IHC; ICC/IF | |
| MAB040Hu25 | Monoclonal Antibody to Vimentin (VIM) | WB; IHC; ICC/IF | |
| MAB040Hu21 | Monoclonal Antibody to Vimentin (VIM) | WB; IHC | |
| MAB040Hu23 | Monoclonal Antibody to Vimentin (VIM) | WB; IHC; ICC/IF | |
| MAB040Hu27 | Monoclonal Antibody to Vimentin (VIM) | WB; IHC; ICC/IF | |
| PAB040Hu02 | Polyclonal Antibody to Vimentin (VIM) | IHC; ICC/IF | |
| Assay Kits | SEB040Hu | ELISA Kit for Vimentin (VIM) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB040Mu01 | Recombinant Vimentin (VIM) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPB040Mu02 | Recombinant Vimentin (VIM) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAB040Mu01 | Polyclonal Antibody to Vimentin (VIM) | WB; IHC; ICC; IP. |
| PAB040Mu02 | Polyclonal Antibody to Vimentin (VIM) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB040Mu | ELISA Kit for Vimentin (VIM) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Vimentin (VIM) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Vimentin (VIM) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Vimentin (VIM) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Vimentin (VIM) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Vimentin (VIM) | ELISA Kit Customized Service Offer |
Organism species: Sus scrofa; Porcine (Pig)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Vimentin (VIM) | Recombinant Protein Customized Service Offer |
| Antibodies | PAB040Po01 | Polyclonal Antibody to Vimentin (VIM) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Vimentin (VIM) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Vimentin (VIM) | ELISA Kit Customized Service Offer |
Organism species: Bos taurus; Bovine (Cattle)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Vimentin (VIM) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Vimentin (VIM) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Vimentin (VIM) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | SEB040Bo | ELISA Kit for Vimentin (VIM) | Enzyme-linked immunosorbent assay for Antigen Detection. |
- "Coding sequence and growth regulation of the human vimentin gene."Mol. Cell. Biol. 6:3614-3620(1986) [PubMed] [Europe PMC] [Abstract]
- "Nucleotide sequence of cDNA covering the complete coding part of the human vimentin gene."Nucleic Acids Res. 18:6692-6692(1990) [PubMed] [Europe PMC] [Abstract]
- "SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma."Br. J. Dermatol. 150:252-258(2004) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Vimentin rather than keratin expression in some hormone-independent breast cancer cell lines and in oncogene-transformed mammary epithelial cells."Cancer Res. 49:4258-4263(1989) [PubMed] [Europe PMC] [Abstract]
- , Submitted (MAY-2006) to UniProtKB