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Growth Hormone Receptor (GHR)

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GHBP; Somatotropin receptor; Growth hormone-binding protein; Serum-binding protein

Growth Hormone Receptor (GHR)
CCC B036
HGNC 4263
MGI 95708
PubMed 18622706
RGD 2687
UniProt P10912
Wiki GHR

Growth hormone receptor, also known as GHR, is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized.

Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature (proportional dwarfism). Other splice variants, including one encoding a soluble form of the protein (GHRtr), have been observed but have not been thoroughly characterized.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB036Hu01 Recombinant Growth Hormone Receptor (GHR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB036Hu01 Polyclonal Antibody to Growth Hormone Receptor (GHR) WB; ICC; IHC-P; IHC-F; ELISA.
MAB036Hu22 Monoclonal Antibody to Growth Hormone Receptor (GHR) WB; IHC; ICC; IP.
MAB036Hu21 Monoclonal Antibody to Growth Hormone Receptor (GHR) WB; IHC; ICC; IP.
Assay Kits SEB036Hu ELISA Kit for Growth Hormone Receptor (GHR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB036Mu01 Recombinant Growth Hormone Receptor (GHR) Positive Control; Immunogen; SDS-PAGE; WB.
RPB036Mu02 Recombinant Growth Hormone Receptor (GHR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB036Mu01 Polyclonal Antibody to Growth Hormone Receptor (GHR) WB; IHC; ICC; IP.
PAB036Mu02 Polyclonal Antibody to Growth Hormone Receptor (GHR) WB; IHC; ICC; IP.
Assay Kits SEB036Mu ELISA Kit for Growth Hormone Receptor (GHR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB036Ra01 Recombinant Growth Hormone Receptor (GHR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB036Ra01 Polyclonal Antibody to Growth Hormone Receptor (GHR) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Growth Hormone Receptor (GHR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Growth Hormone Receptor (GHR) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Growth Hormone Receptor (GHR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Growth Hormone Receptor (GHR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Growth Hormone Receptor (GHR) Polyclonal Antibody Customized Service Offer
Assay Kits SEB036Po ELISA Kit for Growth Hormone Receptor (GHR) Enzyme-linked immunosorbent assay for Antigen Detection.
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  3. "Expression of a human growth hormone (hGH) receptor isoform is predicted by tissue-specific alternative splicing of exon 3 of the hGH receptor gene transcript."Mol. Endocrinol. 6:279-287(1992) [PubMed] [Europe PMC] [Abstract]
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  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
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  13. "Crystal structure of an antagonist mutant of human growth hormone, G120R, in complex with its receptor at 2.9-A resolution."J. Biol. Chem. 271:32197-32203(1996) [PubMed] [Europe PMC] [Abstract]
  14. "Laron dwarfism and mutations of the growth hormone-receptor gene."N. Engl. J. Med. 321:989-995(1989) [PubMed] [Europe PMC] [Abstract]
  15. "Amino acid substitutions in the intracellular part of the growth hormone receptor in a patient with the Laron syndrome."J. Clin. Endocrinol. Metab. 76:54-59(1993) [PubMed] [Europe PMC] [Abstract]
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  17. "Lack of hormone binding in COS-7 cells expressing a mutated growth hormone receptor found in Laron dwarfism."J. Clin. Invest. 91:838-844(1993) [PubMed] [Europe PMC] [Abstract]
  18. "A single amino acid substitution in the exoplasmic domain of the human growth hormone (GH) receptor confers familial GH resistance (Laron syndrome) with positive GH-binding activity by abolishing receptor homodimerization."EMBO J. 13:1386-1395(1994) [PubMed] [Europe PMC] [Abstract]
  19. "Mutations of the growth hormone receptor in children with idiopathic short stature."N. Engl. J. Med. 333:1093-1098(1995) [PubMed] [Europe PMC] [Abstract]
  20. "Nine novel growth hormone receptor gene mutations in patients with Laron syndrome."J. Clin. Endocrinol. Metab. 82:435-437(1997) [PubMed] [Europe PMC] [Abstract]
  21. "A novel mutation affecting the interdomain link region of the growth hormone receptor in a Vietnamese girl, and response to long-term treatment with recombinant human insulin-like growth factor-I and luteinizing hormone-releasing hormone analogue."J. Clin. Endocrinol. Metab. 83:2554-2561(1998) [PubMed] [Europe PMC] [Abstract]
  22. "Growth hormone receptor mutations in children with idiopathic short stature."J. Clin. Endocrinol. Metab. 83:4079-4083(1998) [PubMed] [Europe PMC] [Abstract]
  23. "Four contiguous amino acid substitutions, identified in patients with Laron syndrome, differently affect the binding affinity and intracellular trafficking of the growth hormone receptor."J. Clin. Endocrinol. Metab. 83:4481-4489(1998) [PubMed] [Europe PMC] [Abstract]
  24. "Characterization of single-nucleotide polymorphisms in coding regions of human genes."Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
  25. ErratumNat. Genet. 23:373-373(1999)
  26. "Characterisation of novel missense mutations in the GH receptor gene causing severe growth retardation."Eur. J. Endocrinol. 143:71-76(2000) [PubMed] [Europe PMC] [Abstract]
  27. "Growth hormone receptor variant (L526I) modifies plasma HDL cholesterol phenotype in familial hypercholesterolemia: intra-familial association study in an eight-generation hyperlipidemic kindred."Am. J. Med. Genet. A 121:136-140(2003) [PubMed] [Europe PMC] [Abstract]
  28. "The first homozygous mutation (S226I) in the highly-conserved WSXWS-like motif of the GH receptor causing Laron syndrome: suppression of GH secretion by GnRH analogue therapy not restored by dihydrotestosterone administration."Clin. Endocrinol. (Oxf.) 60:36-40(2004) [PubMed] [Europe PMC] [Abstract]