Placental Cadherin (P-cadherin)

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CDH3; HJMD; PCAD; Cadherin 3 Type 1; CDHP; Cadherin, Placental

Placental Cadherin (P-cadherin)

Placental cadherin (P-cadherin) is a member of the cadherin gene family. Other members include epithelial cadherin (E-cadherin) and neural cadherin (N-cadherin). A great deal is known about N- and E-cadherin. From the cancer standpoint, loss of E-cadherin in lobular breast cancer and in diffuse gastric cancer is a well-established tumor-initiating or promoting event. N-cadherin expression in mammary cell lines can stabilize fibroblast growth factor, resulting in an invasive phenotype. Until recently, P-cadherin was less studied with respect to cancer. It was originally identified as having an important role in implantation and embryogenesis in mice. In a development setting, Daniel et al. showed that P-cadherin is localized to the cap cells in the terminal end buds of the developing murine mammary gland.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB013Hu01 Recombinant Placental Cadherin (P-cadherin) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB013Hu01 Polyclonal Antibody to Placental Cadherin (P-cadherin) WB; IHC; ICC; IP.
LAB013Hu81 FITC-Linked Polyclonal Antibody to Placental Cadherin (P-cadherin) WB; IHC; ICC; IF.
LAB013Hu71 Biotin-Linked Polyclonal Antibody to Placental Cadherin (P-cadherin) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Placental Cadherin (P-cadherin) CLIA Kit Customized Service Offer
n/a ELISA Kit for Placental Cadherin (P-cadherin) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB013Mu01 Recombinant Placental Cadherin (P-cadherin) Positive Control; Immunogen; SDS-PAGE; WB.
RPB013Mu02 Recombinant Placental Cadherin (P-cadherin) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB013Mu01 Polyclonal Antibody to Placental Cadherin (P-cadherin) WB; IHC; ICC; IP.
LAB013Mu81 FITC-Linked Polyclonal Antibody to Placental Cadherin (P-cadherin) WB; IHC; ICC; IF.
LAB013Mu71 Biotin-Linked Polyclonal Antibody to Placental Cadherin (P-cadherin) WB; IHC; ICC.
PAB013Mu02 Polyclonal Antibody to Placental Cadherin (P-cadherin) WB; IHC; ICC; IP.
Assay Kits SEB013Mu ELISA Kit for Placental Cadherin (P-cadherin) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Placental Cadherin (P-cadherin) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Placental Cadherin (P-cadherin) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Placental Cadherin (P-cadherin) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Placental Cadherin (P-cadherin) CLIA Kit Customized Service Offer
n/a ELISA Kit for Placental Cadherin (P-cadherin) ELISA Kit Customized Service Offer
  1. "Molecular cloning of a human Ca2+-dependent cell-cell adhesion molecule homologous to mouse placental cadherin: its low expression in human placental tissues."J. Cell Biol. 109:1787-1794(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "P-cadherin is a basal cell-specific epithelial marker that is not expressed in prostate cancer."Clin. Cancer Res. 3:2121-2128(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas."Cancer Res. 49:2128-2133(1989) [PubMed] [Europe PMC] [Abstract]
  6. "Adhesion signaling by a novel mitotic substrate of src kinases."Oncogene 24:5333-5343(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Hypotrichosis with juvenile macular dystrophy is caused by a mutation in CDH3, encoding P-cadherin."Nat. Genet. 29:134-136(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Crystal structure of a beta-catenin/BCL9/Tcf4 complex."Mol. Cell 24:293-300(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "A missense mutation in CDH3, encoding P-cadherin, causes hypotrichosis with juvenile macular dystrophy."J. Invest. Dermatol. 119:1210-1213(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Distinct CDH3 mutations cause ectodermal dysplasia, ectrodactyly, macular dystrophy (EEM syndrome)."J. Med. Genet. 42:292-298(2005) [PubMed] [Europe PMC] [Abstract]