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Low Density Lipoprotein Receptor Related Protein 1 (LRP1)

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CD91; LRP; A2MR; APOER; APR; TGFBR5; Alpha-2-Macroglobulin Receptor; Prolow-density lipoprotein receptor-related protein 1; Apolipoprotein E receptor

Low Density Lipoprotein Receptor Related Protein 1 (LRP1)
CCC B010
HGNC 6692
MGI 96828
PubMed 23760271
RGD 1307535
UniProt Q07954
Wiki LRP1

  • Low density lipoprotein receptor-related protein 1 (alpha-2-macroglobulin receptor), also known as LRP1 or CD91, is a protein forming a receptor found in the plasma membrane of human cells involved in receptor-mediated endocytosis.Neurons require cholesterol to function. Cholesterol is imported into the neuron by the apolipoprotein apoE4 via LRP1 receptors on the cell surface. It is thought that a causal factor in Alzheimer's is the malfunction of this process which damages neurons by starving them of cholesterol.The protein showed strong calcium binding. Kristensen et al. (1990) and Strickland et al. (1990) demonstrated that LRP is identical to the alpha-2-macroglobulin (A2M) receptor (A2MR). Like the mannose-6-phosphate receptor, the A2MR/LRP molecule is probably bifunctional.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB010Hu01 Recombinant Low Density Lipoprotein Receptor Related Protein 1 (LRP1) Positive Control; Immunogen; SDS-PAGE; WB.
RPB010Hu02 Recombinant Low Density Lipoprotein Receptor Related Protein 1 (LRP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB010Hu01 Polyclonal Antibody to Low Density Lipoprotein Receptor Related Protein 1 (LRP1) WB; IHC; ICC; IP.
MAB010Hu22 Monoclonal Antibody to Low Density Lipoprotein Receptor Related Protein 1 (LRP1) WB
MAB010Hu21 Monoclonal Antibody to Low Density Lipoprotein Receptor Related Protein 1 (LRP1) WB; IHC; ICC; IP.
MAB010Hu23 Monoclonal Antibody to Low Density Lipoprotein Receptor Related Protein 1 (LRP1) WB; IHC; ICC; IP.
MAB010Hu24 Monoclonal Antibody to Low Density Lipoprotein Receptor Related Protein 1 (LRP1) WB; IHC; ICC; IP.
Assay Kits SEB010Hu ELISA Kit for Low Density Lipoprotein Receptor Related Protein 1 (LRP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB010Mu01 Recombinant Low Density Lipoprotein Receptor Related Protein 1 (LRP1) Positive Control; Immunogen; SDS-PAGE; WB.
RPB010Mu02 Recombinant Low Density Lipoprotein Receptor Related Protein 1 (LRP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB010Mu01 Polyclonal Antibody to Low Density Lipoprotein Receptor Related Protein 1 (LRP1) WB; IHC; ICC; IP.
PAB010Mu02 Polyclonal Antibody to Low Density Lipoprotein Receptor Related Protein 1 (LRP1) WB; IHC; ICC; IP.
Assay Kits SEB010Mu ELISA Kit for Low Density Lipoprotein Receptor Related Protein 1 (LRP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Low Density Lipoprotein Receptor Related Protein 1 (LRP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Low Density Lipoprotein Receptor Related Protein 1 (LRP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Low Density Lipoprotein Receptor Related Protein 1 (LRP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Low Density Lipoprotein Receptor Related Protein 1 (LRP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Low Density Lipoprotein Receptor Related Protein 1 (LRP1) ELISA Kit Customized Service Offer
  1. "Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor."EMBO J. 7:4119-4127(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Structure of the gene (LRP1) coding for the human alpha 2-macroglobulin receptor lipoprotein receptor-related protein."Genomics 24:78-89(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Strategy to sequence the 89 exons of the human LRP1 gene coding for the lipoprotein receptor related protein: identification of one expressed mutation among 48 polymorphisms."Genomics 52:138-144(1998) [PubMed] [Europe PMC] [Abstract]
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  6. "Structure of the low-density lipoprotein receptor-related protein (LRP) promoter."Biochim. Biophys. Acta 1009:229-236(1989) [PubMed] [Europe PMC] [Abstract]
  7. "Sequence identity between the alpha 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor."J. Biol. Chem. 265:17401-17404(1990) [PubMed] [Europe PMC] [Abstract]
  8. "Proteolytic processing of the 600 kd low density lipoprotein receptor-related protein (LRP) occurs in a trans-Golgi compartment."EMBO J. 9:1769-1776(1990) [PubMed] [Europe PMC] [Abstract]
  9. "Evidence that the newly cloned low-density-lipoprotein receptor related protein (LRP) is the alpha 2-macroglobulin receptor."FEBS Lett. 276:151-155(1990) [PubMed] [Europe PMC] [Abstract]
  10. "The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds and internalizes Pseudomonas exotoxin A."J. Biol. Chem. 267:12420-12423(1992) [PubMed] [Europe PMC] [Abstract]
  11. "Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP)."J. Biol. Chem. 277:11772-11779(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Platelet-derived growth factor (PDGF)-induced tyrosine phosphorylation of the low density lipoprotein receptor-related protein (LRP). Evidence for integrated co-receptor function between LRP and the PDGF."J. Biol. Chem. 277:15499-15506(2002) [PubMed] [Europe PMC] [Abstract]
  13. "Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain."J. Biol. Chem. 277:18736-18743(2002) [PubMed] [Europe PMC] [Abstract]
  14. "The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65."J. Biol. Chem. 278:41182-41188(2003) [PubMed] [Europe PMC] [Abstract]
  15. "LDL receptor-related proteins in neurodevelopment."Traffic 4:291-301(2003) [PubMed] [Europe PMC] [Abstract]
  16. "Serine and threonine phosphorylation of the low density lipoprotein receptor-related protein by protein kinase Calpha regulates endocytosis and association with adaptor molecules."J. Biol. Chem. 279:40536-40544(2004) [PubMed] [Europe PMC] [Abstract]
  17. "Functions of sorting nexin 17 domains and recognition motif for P-selectin trafficking."J. Mol. Biol. 347:813-825(2005) [PubMed] [Europe PMC] [Abstract]
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  19. "Identification of the ligands of protein interaction domains through a functional approach."Mol. Cell. Proteomics 6:333-345(2007) [PubMed] [Europe PMC] [Abstract]
  20. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  21. "A strategy for precise and large scale identification of core fucosylated glycoproteins."Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  23. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  24. "NMR solution structure of complement-like repeat CR8 from the low density lipoprotein receptor-related protein."J. Biol. Chem. 274:14130-14136(1999) [PubMed] [Europe PMC] [Abstract]
  25. "NMR solution structure of complement-like repeat CR3 from the low density lipoprotein receptor-related protein. Evidence for specific binding to the receptor binding domain of human alpha(2)-macroglobulin."J. Biol. Chem. 275:3264-3269(2000) [PubMed] [Europe PMC] [Abstract]
  26. "Calcium coordination and pH dependence of the calcium affinity of ligand-binding repeat CR7 from the LRP. Comparison with related domains from the LRP and the LDL receptor."Biochemistry 40:15127-15134(2001) [PubMed] [Europe PMC] [Abstract]
  27. "Binding site structure of one LRP-RAP complex: implications for a common ligand-receptor binding motif."J. Mol. Biol. 362:700-716(2006) [PubMed] [Europe PMC] [Abstract]
  28. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  29. "Diagnostic exome sequencing in persons with severe intellectual disability."N. Engl. J. Med. 367:1921-1929(2012) [PubMed] [Europe PMC] [Abstract]