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Very Low Density Lipoprotein Receptor (VLDLR)

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VLDL-R

Very Low Density Lipoprotein Receptor (VLDLR)
CCC B009
HGNC 12698
MGI 98935
PubMed 10488949
RGD 3963
UniProt P98155
Wiki VLDLR

VLDLR is a lipoprotein receptor that shows considerable similarity to the low-density-lipoprotein receptor. This receptor has been suggested to be important for the metabolism of apoprotein-E-containing triacylglycerol-rich lipoproteins, such as very-low-density-lipoprotein (VLDL), beta-migrating VLDL and intermediate-density lipoprotein. It is also one of the receptors of reelin, an extracellular matrix protein which regulates the processes of neuronal migration and synaptic plasticity.In rabbits, the mRNA for the VLDLR was found to be most abundant in heart, skeletal muscle, and adipose tissue, but was not detectable in the liver. Human mRNA studies showed a very similar pattern of distribution. Hence, it has been suggested that the VLDLR might play an important role in the fatty acid metabolism of non-hepatic tissues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB009Hu01 Recombinant Very Low Density Lipoprotein Receptor (VLDLR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB009Hu01 Polyclonal Antibody to Very Low Density Lipoprotein Receptor (VLDLR) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Very Low Density Lipoprotein Receptor (VLDLR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Very Low Density Lipoprotein Receptor (VLDLR) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Very Low Density Lipoprotein Receptor (VLDLR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Very Low Density Lipoprotein Receptor (VLDLR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Very Low Density Lipoprotein Receptor (VLDLR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Very Low Density Lipoprotein Receptor (VLDLR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Very Low Density Lipoprotein Receptor (VLDLR) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB009Ra01 Recombinant Very Low Density Lipoprotein Receptor (VLDLR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB009Ra01 Polyclonal Antibody to Very Low Density Lipoprotein Receptor (VLDLR) WB; IHC; ICC; IP.
MAB009Ra21 Monoclonal Antibody to Very Low Density Lipoprotein Receptor (VLDLR) WB; IHC; ICC; IP.
Assay Kits SEB009Ra ELISA Kit for Very Low Density Lipoprotein Receptor (VLDLR) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB009Ra CLIA Kit for Very Low Density Lipoprotein Receptor (VLDLR) Chemiluminescent immunoassay for Antigen Detection.
  1. "Cloning of a cDNA encoding a putative human very low density lipoprotein/apolipoprotein E receptor and assignment of the gene to chromosome 9pter-p23."Somat. Cell Mol. Genet. 19:557-569(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization and tissue-specific expression of the human 'very low density lipoprotein (VLDL) receptor' mRNA."Hum. Mol. Genet. 3:531-537(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Structure, chromosome location, and expression of the human very low density lipoprotein receptor gene."J. Biol. Chem. 269:2173-2182(1994) [PubMed] [Europe PMC] [Abstract]
  4. "Human very-low-density lipoprotein receptor complementary DNA and deduced amino acid sequence and localization of its gene (VLDLR) to chromosome band 9p24 by fluorescence in situ hybridization."Genomics 20:298-300(1994) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "A cellular receptor of human rhinovirus type 2, the very-low-density lipoprotein receptor, binds to two neighboring proteins of the viral capsid."J. Virol. 77:8504-8511(2003) [PubMed] [Europe PMC] [Abstract]
  8. "The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2."J. Biol. Chem. 283:2363-2372(2008) [PubMed] [Europe PMC] [Abstract]
  9. "The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2."J. Biol. Chem. 285:19720-19726(2010) [PubMed] [Europe PMC] [Abstract]
  10. "X-ray structure of a minor group human rhinovirus bound to a fragment of its cellular receptor protein."Nat. Struct. Mol. Biol. 11:429-434(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Characterization of single-nucleotide polymorphisms in coding regions of human genes."Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
  12. ErratumNat. Genet. 23:373-373(1999)
  13. "Homozygous deletion of the very low density lipoprotein receptor gene causes autosomal recessive cerebellar hypoplasia with cerebral gyral simplification."Am. J. Hum. Genet. 77:477-483(2005) [PubMed] [Europe PMC] [Abstract]