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Protein Zero, Myelin (MPZ)

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P0; DSS; CHM; CMT4E; CMT1; CMT1B; CMT2I; CMT2J; CMTDI3; HMSNIB; MPP; Myelin Protein Zero; Charcot-Marie-Tooth Neuropathy 1B; Myelin peripheral protein

Protein Zero, Myelin (MPZ)
CCC A999
HGNC 7225
MGI 103177
PubMed 16373334
RGD 3109
UniProt P25189
Wiki P0_protein

Myelin protein-zero is the major structural protein of peripheral myelin.Hayasaka et al. (1993) stated that the MPZ gene contains 6 exons.You et al. (1991) found that the Mpz gene in the mouse, like that in the rat, contains 6 exons that span about 7 kb of genomic DNA.Myelin protein-zero is the major structural protein of peripheral myelin, accounting for more than 50% of the protein present in the sheath of peripheral nerves. Expression of the MPZ gene is restricted to Schwann cells; MPZ is not found in the CNS. An integral membrane glycoprotein of 28 kD, MPZ is thought to link adjacent lamellae and thereby stabilize the myelin assembly. The other 3 major components of myelin are myelin basic protein (MBP), myelin proteolipid protein (PLP1), and myelin-associated glycoprotein (MAG).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA999Hu01 Recombinant Protein Zero, Myelin (MPZ) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA999Hu01 Polyclonal Antibody to Protein Zero, Myelin (MPZ) WB
MAA999Hu21 Monoclonal Antibody to Protein Zero, Myelin (MPZ) WB
MAA999Hu22 Monoclonal Antibody to Protein Zero, Myelin (MPZ) WB
Assay Kits SEA999Hu ELISA Kit for Protein Zero, Myelin (MPZ) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Zero, Myelin (MPZ) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Zero, Myelin (MPZ) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Zero, Myelin (MPZ) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Zero, Myelin (MPZ) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Zero, Myelin (MPZ) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA999Ra01 Recombinant Protein Zero, Myelin (MPZ) Positive Control; Immunogen; SDS-PAGE; WB.
RPA999Ra02 Recombinant Protein Zero, Myelin (MPZ) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA999Ra01 Polyclonal Antibody to Protein Zero, Myelin (MPZ) WB
MAA999Ra21 Monoclonal Antibody to Protein Zero, Myelin (MPZ) WB; IHC; ICC; IP.
Assay Kits SEA999Ra ELISA Kit for Protein Zero, Myelin (MPZ) Enzyme-linked immunosorbent assay for Antigen Detection.
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  37. "The Thr124Met mutation in the peripheral myelin protein zero (MPZ) gene is associated with a clinically distinct Charcot-Marie-Tooth phenotype."Brain 122:281-290(1999) [PubMed] [Europe PMC] [Abstract]
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  43. "Focally folded myelin in Charcot-Marie-Tooth neuropathy type 1B with Ser49Leu in the myelin protein zero."Acta Neuropathol. 100:299-304(2000) [PubMed] [Europe PMC] [Abstract]
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  55. "Two amino-acid substitutions in the myelin protein zero gene of a case of Charcot-Marie-Tooth disease associated with light-near dissociation."Neuromuscul. Disord. 12:281-285(2002) [PubMed] [Europe PMC] [Abstract]
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  57. "Demyelinating and axonal features of Charcot-Marie-Tooth disease with mutations of myelin-related proteins (PMP22, MPZ and Cx32): a clinicopathological study of 205 Japanese patients."Brain 126:134-151(2003) [PubMed] [Europe PMC] [Abstract]
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  67. "Gene dosage sensitivity of a novel mutation in the intracellular domain of P0 associated with Charcot-Marie-Tooth disease type 1B."Neuromuscul. Disord. 16:183-187(2006) [PubMed] [Europe PMC] [Abstract]
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  69. "Chronic cough due to Thr124Met mutation in the peripheral myelin protein zero (MPZ gene)."Neurology 62:1905-1906(2004) [PubMed] [Europe PMC] [Abstract]
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