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Protein Zero, Myelin (MPZ)

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P0; DSS; CHM; CMT4E; CMT1; CMT1B; CMT2I; CMT2J; CMTDI3; HMSNIB; MPP; Myelin Protein Zero; Charcot-Marie-Tooth Neuropathy 1B; Myelin peripheral protein

Protein Zero, Myelin (MPZ)
CCC A999
HGNC 7225
MGI 103177
PubMed 16373334
RGD 3109
UniProt P25189
Wiki P0_protein

Myelin protein-zero is the major structural protein of peripheral myelin.Hayasaka et al. (1993) stated that the MPZ gene contains 6 exons.You et al. (1991) found that the Mpz gene in the mouse, like that in the rat, contains 6 exons that span about 7 kb of genomic DNA.Myelin protein-zero is the major structural protein of peripheral myelin, accounting for more than 50% of the protein present in the sheath of peripheral nerves. Expression of the MPZ gene is restricted to Schwann cells; MPZ is not found in the CNS. An integral membrane glycoprotein of 28 kD, MPZ is thought to link adjacent lamellae and thereby stabilize the myelin assembly. The other 3 major components of myelin are myelin basic protein (MBP), myelin proteolipid protein (PLP1), and myelin-associated glycoprotein (MAG).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA999Hu01 Recombinant Protein Zero, Myelin (MPZ) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA999Hu01 Polyclonal Antibody to Protein Zero, Myelin (MPZ) WB; IHC; ICC; IP.
MAA999Hu21 Monoclonal Antibody to Protein Zero, Myelin (MPZ) WB
MAA999Hu22 Monoclonal Antibody to Protein Zero, Myelin (MPZ) WB
Assay Kits SEA999Hu ELISA Kit for Protein Zero, Myelin (MPZ) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Zero, Myelin (MPZ) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Zero, Myelin (MPZ) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Zero, Myelin (MPZ) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Zero, Myelin (MPZ) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Zero, Myelin (MPZ) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA999Ra01 Recombinant Protein Zero, Myelin (MPZ) Positive Control; Immunogen; SDS-PAGE; WB.
RPA999Ra02 Recombinant Protein Zero, Myelin (MPZ) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA999Ra01 Polyclonal Antibody to Protein Zero, Myelin (MPZ) WB; IHC; ICC; IP.
MAA999Ra21 Monoclonal Antibody to Protein Zero, Myelin (MPZ) WB; IHC; ICC; IP.
Assay Kits SEA999Ra ELISA Kit for Protein Zero, Myelin (MPZ) Enzyme-linked immunosorbent assay for Antigen Detection.
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  55. "Two amino-acid substitutions in the myelin protein zero gene of a case of Charcot-Marie-Tooth disease associated with light-near dissociation."Neuromuscul. Disord. 12:281-285(2002) [PubMed] [Europe PMC] [Abstract]
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  66. "Hearing loss as the first feature of late-onset axonal CMT disease due to a novel P0 mutation."Neurology 63:733-735(2004) [PubMed] [Europe PMC] [Abstract]
  67. "Gene dosage sensitivity of a novel mutation in the intracellular domain of P0 associated with Charcot-Marie-Tooth disease type 1B."Neuromuscul. Disord. 16:183-187(2006) [PubMed] [Europe PMC] [Abstract]
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