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Glypican 4 (GPC4)

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K-Glypican; Glypican Proteoglycan 4; Secreted glypican-4

Glypican 4 (GPC4)
CCC A998
HGNC 4452
MGI 104902
PubMed 11066092
RGD 1359399
UniProt O75487
Wiki Glypican_4

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation.

The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome.The deduced 556-amino acid GPC4 protein is 93.5% identical to mouse K-glypican. Northern blot analysis detected 2 GPC4 transcripts of 2.9 kb and 4.3 kb in most human fetal and adult tissues tested.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA998Hu01 Recombinant Glypican 4 (GPC4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA998Hu01 Polyclonal Antibody to Glypican 4 (GPC4) WB; IHC; ICC; IP.
MAA998Hu22 Monoclonal Antibody to Glypican 4 (GPC4) WB; IHC; ICC; IP.
LAA998Hu81 FITC-Linked Polyclonal Antibody to Glypican 4 (GPC4) WB; IHC; ICC; IF.
LAA998Hu71 Biotin-Linked Polyclonal Antibody to Glypican 4 (GPC4) WB; IHC; ICC.
Assay Kits SEA998Hu ELISA Kit for Glypican 4 (GPC4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA998Mu01 Recombinant Glypican 4 (GPC4) Positive Control; Immunogen; SDS-PAGE; WB.
RPA998Mu02 Recombinant Glypican 4 (GPC4) Positive Control; Immunogen; SDS-PAGE; WB.
APA998Mu01 Active Glypican 4 (GPC4) Cell culture; Activity Assays.
Antibodies PAA998Mu01 Polyclonal Antibody to Glypican 4 (GPC4) WB; IHC; ICC; IP.
PAA998Mu02 Polyclonal Antibody to Glypican 4 (GPC4) WB; IHC; ICC; IP.
Assay Kits SEA998Mu ELISA Kit for Glypican 4 (GPC4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA998Ra01 Recombinant Glypican 4 (GPC4) Positive Control; Immunogen; SDS-PAGE; WB.
APA998Ra01 Active Glypican 4 (GPC4) Cell culture; Activity Assays.
Antibodies PAA998Ra01 Polyclonal Antibody to Glypican 4 (GPC4) WB; IHC; ICC; IP.
Assay Kits SEA998Ra ELISA Kit for Glypican 4 (GPC4) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "GPC4, the gene for human K-glypican, flanks GPC3 on Xq26: deletion of the GPC3-GPC4 gene cluster in one family with Simpson-Golabi-Behmel syndrome."Genomics 53:1-11(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  7. "Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: identification of loss-of-function mutations in the GPC3 gene."Hum. Mol. Genet. 9:1321-1328(2000) [PubMed] [Europe PMC] [Abstract]