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Cholinergic Receptor, Nicotinic, Alpha 1 (CHRNa1)

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CHR-NA1; N-AChRA1; NAChRA1; ACHRA; ACHRD; CMS2A; FCCMS; SCCMS; Acetylcholine receptor subunit alpha; N-AChR-A1; Neuronal Acetylcholine Receptor Alpha 1,Muscle

Cholinergic Receptor, Nicotinic, Alpha 1 (CHRNa1)
CCC A981
HGNC 1955
MGI 87885
PubMed 8738961
RGD 69277
UniProt P02708
Wiki CHRNA1

nAChRs, are cholinergic receptors that form ligand-gated ion channels in the plasma membranes of certain neurons. Being ionotropic receptors, nAChRs are directly linked to an ion channel and do not make use of a second messenger as metabotropic receptors do.The muscle acetylcholine receptor consiststs of 5 subunits of 4 different types: 2 alpha isoforms and 1 each of beta, gamma, and delta subunits.2 This gene encodes an alpha subunit that plays a role in acetlycholine binding/channel gating. Alternatively spliced transcript variants encoding different isoforms have been identified. Keiger et al. (2003) surveyed the developmental expression of nicotinic receptors, including CHRNA1, in chick and human spinal cord.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA981Hu01 Recombinant Cholinergic Receptor, Nicotinic, Alpha 1 (CHRNa1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA981Hu01 Polyclonal Antibody to Cholinergic Receptor, Nicotinic, Alpha 1 (CHRNa1) WB; IHC; ICC; IP.
MAA981Hu21 Monoclonal Antibody to Cholinergic Receptor, Nicotinic, Alpha 1 (CHRNa1) WB; IHC; ICC; IP.
Assay Kits SEA981Hu ELISA Kit for Cholinergic Receptor, Nicotinic, Alpha 1 (CHRNa1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA981Hu CLIA Kit for Cholinergic Receptor, Nicotinic, Alpha 1 (CHRNa1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cholinergic Receptor, Nicotinic, Alpha 1 (CHRNa1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cholinergic Receptor, Nicotinic, Alpha 1 (CHRNa1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cholinergic Receptor, Nicotinic, Alpha 1 (CHRNa1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cholinergic Receptor, Nicotinic, Alpha 1 (CHRNa1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cholinergic Receptor, Nicotinic, Alpha 1 (CHRNa1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA981Ra01 Recombinant Cholinergic Receptor, Nicotinic, Alpha 1 (CHRNa1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA981Ra01 Polyclonal Antibody to Cholinergic Receptor, Nicotinic, Alpha 1 (CHRNa1) WB; IHC; ICC; IP.
MAA981Ra21 Monoclonal Antibody to Cholinergic Receptor, Nicotinic, Alpha 1 (CHRNa1) WB; IHC; ICC; IP.
Assay Kits SEA981Ra ELISA Kit for Cholinergic Receptor, Nicotinic, Alpha 1 (CHRNa1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Cloning and sequence analysis of calf cDNA and human genomic DNA encoding alpha-subunit precursor of muscle acetylcholine receptor."Nature 305:818-823(1983) [PubMed] [Europe PMC] [Abstract]
  2. "The human medulloblastoma cell line TE671 expresses a muscle-like acetylcholine receptor. Cloning of the alpha-subunit cDNA."FEBS Lett. 226:235-240(1988) [PubMed] [Europe PMC] [Abstract]
  3. "The human muscle nicotinic acetylcholine receptor alpha-subunit exist as two isoforms: a novel exon."EMBO J. 9:2101-2106(1990) [PubMed] [Europe PMC] [Abstract]
  4. "Cloning of a cDNA coding for the acetylcholine receptor alpha-subunit from a thymoma associated with myasthenia gravis."Thymus 23:103-113(1994) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Amphipathic segment of the nicotinic receptor alpha subunit contains epitopes recognized by T lymphocytes in myasthenia gravis."J. Clin. Invest. 81:657-660(1988) [PubMed] [Europe PMC] [Abstract]
  7. "Differential expression of human nicotinic acetylcholine receptor alpha subunit variants in muscle and non-muscle tissues."Nucleic Acids Res. 21:233-237(1993) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Mutation of the acetylcholine receptor alpha subunit causes a slow-channel myasthenic syndrome by enhancing agonist binding affinity."Neuron 15:229-239(1995) [PubMed] [Europe PMC] [Abstract]
  10. "New mutations in acetylcholine receptor subunit genes reveal heterogeneity in the slow-channel congenital myasthenic syndrome."Hum. Mol. Genet. 5:1217-1227(1996) [PubMed] [Europe PMC] [Abstract]
  11. "Mutations in different functional domains of the human muscle acetylcholine receptor alpha subunit in patients with the slow-channel congenital myasthenic syndrome."Hum. Mol. Genet. 6:767-774(1997) [PubMed] [Europe PMC] [Abstract]
  12. "Slow-channel myasthenic syndrome caused by enhanced activation, desensitization, and agonist binding affinity attributable to mutation in the M2 domain of the acetylcholine receptor alpha subunit."J. Neurosci. 17:5651-5665(1997) [PubMed] [Europe PMC] [Abstract]
  13. "Acetylcholine receptor M3 domain: stereochemical and volume contributions to channel gating."Nat. Neurosci. 2:226-233(1999) [PubMed] [Europe PMC] [Abstract]
  14. ErratumNat. Neurosci. 2:485-485(1999)
  15. "Mutation causing severe myasthenia reveals functional asymmetry of AChR signature cystine loops in agonist binding and gating."J. Clin. Invest. 111:497-505(2003) [PubMed] [Europe PMC] [Abstract]
  16. "Mutation in the AChR ion channel gate underlies a fast channel congenital myasthenic syndrome."Neurology 62:1090-1096(2004) [PubMed] [Europe PMC] [Abstract]
  17. "Slow-channel mutation in acetylcholine receptor alphaM4 domain and its efficient knockdown."Ann. Neurol. 60:128-136(2006) [PubMed] [Europe PMC] [Abstract]
  18. "Acetylcholine receptor pathway mutations explain various fetal akinesia deformation sequence disorders." Am. J. Hum. Genet. 82:464-476(2008) [PubMed] [Europe PMC] [Abstract]