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Retinoic Acid Receptor Alpha (RARa)

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RAR-A; NR1B1; RAR; RAR-Alpha; Nuclear Receptor Subfamily 1 Group B Member 1

Retinoic Acid Receptor Alpha (RARa)
CCC A976
HGNC 9864
MGI 97856
PubMed 19725108
RGD 3534
UniProt P10276
Wiki RARA

The retinoic acid receptor (RAR) is a type of nuclear receptor which is activated by both all-trans retinoic acid and 9-cis retinoic acid. There are three retinoic acid receptors (RAR), RAR-alpha, RAR-beta, and RAR-gamma encoded by the RARA, RARB, RARG genes respectively. Each receptor isoform has several splice variants: two- for alpha, four- for beta and two- for gamma.As with other type II nuclear receptors, RAR heterodimerizes with RXR and in the absence of ligand, the RAR/RXR dimer binds to hormone response elements complexed with corepressor protein. Binding of agonist ligands to RAR results in dissociation of corepressor and recruitment of coactivator protein which in turn promotes transcription of the downstream target gene into mRNA and eventually protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA976Hu01 Recombinant Retinoic Acid Receptor Alpha (RARa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA976Hu01 Polyclonal Antibody to Retinoic Acid Receptor Alpha (RARa) WB; IHC; ICC; IP.
MAA976Hu22 Monoclonal Antibody to Retinoic Acid Receptor Alpha (RARa) WB; IHC; ICC; IP.
Assay Kits SEA976Hu ELISA Kit for Retinoic Acid Receptor Alpha (RARa) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA976Mu01 Recombinant Retinoic Acid Receptor Alpha (RARa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA976Mu01 Polyclonal Antibody to Retinoic Acid Receptor Alpha (RARa) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Retinoic Acid Receptor Alpha (RARa) CLIA Kit Customized Service Offer
n/a ELISA Kit for Retinoic Acid Receptor Alpha (RARa) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA976Ra01 Recombinant Retinoic Acid Receptor Alpha (RARa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA976Ra01 Polyclonal Antibody to Retinoic Acid Receptor Alpha (RARa) WB; IHC; ICC; IP.
MAA976Ra21 Monoclonal Antibody to Retinoic Acid Receptor Alpha (RARa) WB; IHC; ICC; IP.
Assay Kits SEA976Ra ELISA Kit for Retinoic Acid Receptor Alpha (RARa) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Identification of a receptor for the morphogen retinoic acid."Nature 330:624-629(1987) [PubMed] [Europe PMC] [Abstract]
  2. "PLZF-RAR alpha fusion proteins generated from the variant t(11;17)(q23;q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptors."Proc. Natl. Acad. Sci. U.S.A. 91:1178-1182(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Genomic structure of the human retinoic acid receptor-alpha1 gene."Mamm. Genome 10:528-529(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Retinoic acid receptor alpha1 variants, RARalpha1DeltaB and RARalpha1DeltaBC, define a new class of nuclear receptor isoforms."Nucleic Acids Res. 29:4901-4908(2001) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Characterization of a functional promoter for the human retinoic acid receptor-alpha (hRAR-alpha)."Nucleic Acids Res. 18:6799-6806(1990) [PubMed] [Europe PMC] [Abstract]
  8. "A human retinoic acid receptor which belongs to the family of nuclear receptors."Nature 330:444-450(1987) [PubMed] [Europe PMC] [Abstract]
  9. "The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion."Blood 87:882-886(1996) [PubMed] [Europe PMC] [Abstract]
  10. "Cytogenetics, FISH and RT-PCR analysis of acute promyelocytic leukemia: structure of the fusion point in a case lacking classic t(15;17) translocation."Leuk. Lymphoma 44:111-115(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300."Cell 90:569-580(1997) [PubMed] [Europe PMC] [Abstract]
  12. "A nuclear factor ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo."J. Biol. Chem. 274:34283-34293(1999) [PubMed] [Europe PMC] [Abstract]
  13. "Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha."J. Biol. Chem. 277:28624-28630(2002) [PubMed] [Europe PMC] [Abstract]
  14. "ERAP140, a conserved tissue-specific nuclear receptor coactivator."Mol. Cell. Biol. 22:3358-3372(2002) [PubMed] [Europe PMC] [Abstract]
  15. "Requirement of the coiled-coil domain of PML-RARalpha oncoprotein for localization, sumoylation, and inhibition of monocyte differentiation."Biochem. Biophys. Res. Commun. 330:746-754(2005) [PubMed] [Europe PMC] [Abstract]
  16. "The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling."Cell 122:835-847(2005) [PubMed] [Europe PMC] [Abstract]
  17. "Akt phosphorylates and suppresses the transactivation of retinoic acid receptor alpha."Biochem. J. 395:653-662(2006) [PubMed] [Europe PMC] [Abstract]
  18. "Additional sex comb-like 1 (ASXL1), in cooperation with SRC-1, acts as a ligand-dependent coactivator for retinoic acid receptor."J. Biol. Chem. 281:17588-17598(2006) [PubMed] [Europe PMC] [Abstract]
  19. "RIF-1, a novel nuclear receptor corepressor that associates with the nuclear matrix."J. Cell. Biochem. 102:1021-1035(2007) [PubMed] [Europe PMC] [Abstract]
  20. "Small ubiquitin-like modifier-2 modification of retinoic acid receptor-alpha regulates its subcellular localization and transcriptional activity."Endocrinology 150:5586-5595(2009) [PubMed] [Europe PMC] [Abstract]
  21. "GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis."Nature 459:455-459(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Activity of retinoic acid receptor-alpha is directly regulated at its protein kinase A sites in response to follicle-stimulating hormone signaling."Endocrinology 151:2361-2372(2010) [PubMed] [Europe PMC] [Abstract]
  23. "Familial focal segmental glomerulosclerosis (FSGS)-linked alpha-actinin 4 (ACTN4) protein mutants lose ability to activate transcription by nuclear hormone receptors."J. Biol. Chem. 287:12027-12035(2012) [PubMed] [Europe PMC] [Abstract]
  24. "Structure of the RXR-RAR DNA-binding complex on the retinoic acid response element DR1."EMBO J. 19:1045-1054(2000) [PubMed] [Europe PMC] [Abstract]
  25. "Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains."Mol. Cell 5:289-298(2000) [PubMed] [Europe PMC] [Abstract]
  26. "A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor."Nat. Struct. Mol. Biol. 17:801-807(2010) [PubMed] [Europe PMC] [Abstract]