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ATP Binding Cassette Transporter G2 (ABCG2)

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CDw338; CD338; ABC-G2; MRX; BCRP1; ABC15; ABCP; BCRP; BMDP; MXR; MXR1; Mitoxantrone resistance-associated protein; Breast Cancer Resistance Protein 1; Urate exporter

ATP Binding Cassette Transporter G2 (ABCG2)
CCC A960
HGNC 74
MGI 1347061
PubMed 11801536
RGD 631345
UniProt Q9UNQ0
Wiki ABCG2

ATP-binding cassette, sub-family G (WHITE), member 2 is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA960Hu01 Recombinant ATP Binding Cassette Transporter G2 (ABCG2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA960Hu01 Polyclonal Antibody to ATP Binding Cassette Transporter G2 (ABCG2) WB; IHC; ICC; IP.
MAA960Hu22 Monoclonal Antibody to ATP Binding Cassette Transporter G2 (ABCG2) WB; IHC; ICC; IP.
Assay Kits SEA960Hu ELISA Kit for ATP Binding Cassette Transporter G2 (ABCG2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA960Mu01 Recombinant ATP Binding Cassette Transporter G2 (ABCG2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA960Mu02 Recombinant ATP Binding Cassette Transporter G2 (ABCG2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA960Mu01 Polyclonal Antibody to ATP Binding Cassette Transporter G2 (ABCG2) WB
PAA960Mu02 Polyclonal Antibody to ATP Binding Cassette Transporter G2 (ABCG2) WB; IHC; ICC; IP.
Assay Kits SEA960Mu ELISA Kit for ATP Binding Cassette Transporter G2 (ABCG2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATP Binding Cassette Transporter G2 (ABCG2) Recombinant Protein Customized Service Offer
Antibodies PAA960Ra01 Polyclonal Antibody to ATP Binding Cassette Transporter G2 (ABCG2) Testing in progress.
Assay Kits SEA960Ra ELISA Kit for ATP Binding Cassette Transporter G2 (ABCG2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance."Cancer Res. 58:5337-5339(1998) [PubMed] [Europe PMC] [Abstract]
  2. "A multidrug resistance transporter from human MCF-7 breast cancer cells."Proc. Natl. Acad. Sci. U.S.A. 95:15665-15670(1998) [PubMed] [Europe PMC] [Abstract]
  3. ErratumProc. Natl. Acad. Sci. U.S.A. 96:2569-2569(1999)
  4. "Identification of breast cancer resistant protein/mitoxantrone resistance/placenta-specific, ATP-binding cassette transporter as a transporter of NB-506 and J-107088, topoisomerase I inhibitors with an indolocarbazole structure."Cancer Res. 61:2827-2832(2001) [PubMed] [Europe PMC] [Abstract]
  5. "The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype."Nat. Med. 7:1028-1034(2001) [PubMed] [Europe PMC] [Abstract]
  6. "The expression and functional characterization of ABCG2 in brain endothelial cells and vessels."FASEB J. 17:2085-2087(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes."Cancer Res. 59:8-13(1999) [PubMed] [Europe PMC] [Abstract]
  11. "Role of ABCG1 and other ABCG family members in lipid metabolism."J. Lipid Res. 42:1513-1520(2001) [PubMed] [Europe PMC] [Abstract]
  12. "Characterization of oligomeric human half-ABC transporter ATP-binding cassette G2."J. Biol. Chem. 279:19781-19789(2004) [PubMed] [Europe PMC] [Abstract]
  13. "N-linked glycosylation of the human ABC transporter ABCG2 on asparagine 596 is not essential for expression, transport activity, or trafficking to the plasma membrane."Biochemistry 44:5420-5429(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Single amino acid (482) variants of the ABCG2 multidrug transporter: major differences in transport capacity and substrate recognition."Biochim. Biophys. Acta 1668:53-63(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Effect of Walker A mutation (K86M) on oligomerization and surface targeting of the multidrug resistance transporter ABCG2."J. Cell Sci. 118:1417-1426(2005) [PubMed] [Europe PMC] [Abstract]
  16. "Intramolecular disulfide bond is a critical check point determining degradative fates of ATP-binding cassette (ABC) transporter ABCG2 protein."J. Biol. Chem. 282:27841-27846(2007) [PubMed] [Europe PMC] [Abstract]
  17. "Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study."Lancet 372:1953-1961(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout."Proc. Natl. Acad. Sci. U.S.A. 106:10338-10342(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Common defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a Japanese population." Sci. Transl. Med. 1:5ra11-5ra11(2009) [PubMed] [Europe PMC] [Abstract]
  20. "ABCG2 transports and transfers heme to albumin through its large extracellular loop."J. Biol. Chem. 285:33123-33133(2010) [PubMed] [Europe PMC] [Abstract]
  21. "ABCG2 is a high-capacity urate transporter and its genetic impairment increases serum uric acid levels in humans."Nucleosides Nucleotides Nucleic Acids 30:1091-1097(2011) [PubMed] [Europe PMC] [Abstract]
  22. "Human ABCG2: structure, function, and its role in multidrug resistance."Int. J. Biochem. Mol. Biol. 3:1-27(2012) [PubMed] [Europe PMC] [Abstract]
  23. "ABCG2 null alleles define the Jr(a-) blood group phenotype."Nat. Genet. 44:131-132(2012) [PubMed] [Europe PMC] [Abstract]
  24. "Null alleles of ABCG2 encoding the breast cancer resistance protein define the new blood group system Junior."Nat. Genet. 44:174-177(2012) [PubMed] [Europe PMC] [Abstract]
  25. "Mitochondrial localization of ABC transporter ABCG2 and its function in 5-aminolevulinic acid-mediated protoporphyrin IX accumulation."PLoS ONE 7:E50082-E50082(2012) [PubMed] [Europe PMC] [Abstract]
  26. "Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8."J. Hum. Genet. 47:285-310(2002) [PubMed] [Europe PMC] [Abstract]
  27. "Eight novel single nucleotide polymorphisms in ABCG2/BCRP in Japanese cancer patients administered irinotacan."Drug Metab. Pharmacokinet. 18:212-217(2003) [PubMed] [Europe PMC] [Abstract]
  28. "Natural allelic variants of breast cancer resistance protein (BCRP) and their relationship to BCRP expression in human intestine."Pharmacogenetics 13:19-28(2003) [PubMed] [Europe PMC] [Abstract]
  29. "Single nucleotide polymorphisms modify the transporter activity of ABCG2."Cancer Chemother. Pharmacol. 56:161-172(2005) [PubMed] [Europe PMC] [Abstract]
  30. "Genetic variation and haplotype structure of the ABC transporter gene ABCG2 in a Japanese population."Drug Metab. Pharmacokinet. 21:109-121(2006) [PubMed] [Europe PMC] [Abstract]