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Pyruvate Dehydrogenase Kinase 4 (PDK4)

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[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial; Pyruvate Dehydrogenase Kinase Isozyme 4

Pyruvate Dehydrogenase Kinase 4 (PDK4)
CCC A958
HGNC 8812
MGI 1351481
PubMed 12099888
RGD 69061
UniProt Q16654
Wiki PDK4

Pyruvate dehydrogenase kinase isozyme 4, mitochondrial is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin.

The PDK4 gene encodes a protein with a calculated molecular weight of 46,466. PDK4 mRNA was detected in all tissues examined, with the highest levels in heart and skeletal muscle. The PDK4 gene consists of 11 exons spanning approximately 16 kb.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA958Hu01 Recombinant Pyruvate Dehydrogenase Kinase 4 (PDK4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA958Hu01 Polyclonal Antibody to Pyruvate Dehydrogenase Kinase 4 (PDK4) WB; IHC; ICC; IP.
Assay Kits SEA958Hu ELISA Kit for Pyruvate Dehydrogenase Kinase 4 (PDK4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA958Mu01 Recombinant Pyruvate Dehydrogenase Kinase 4 (PDK4) Positive Control; Immunogen; SDS-PAGE; WB.
RPA958Mu02 Recombinant Pyruvate Dehydrogenase Kinase 4 (PDK4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA958Mu01 Polyclonal Antibody to Pyruvate Dehydrogenase Kinase 4 (PDK4) WB; IHC; ICC; IP.
PAA958Mu02 Polyclonal Antibody to Pyruvate Dehydrogenase Kinase 4 (PDK4) WB; IHC; ICC; IP.
Assay Kits SEA958Mu ELISA Kit for Pyruvate Dehydrogenase Kinase 4 (PDK4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pyruvate Dehydrogenase Kinase 4 (PDK4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pyruvate Dehydrogenase Kinase 4 (PDK4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pyruvate Dehydrogenase Kinase 4 (PDK4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pyruvate Dehydrogenase Kinase 4 (PDK4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pyruvate Dehydrogenase Kinase 4 (PDK4) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of PDK4 on 7q21.3 encoding a fourth pyruvate dehydrogenase kinase isoenzyme in human."J. Biol. Chem. 271:22376-22382(1996) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Pyruvate dehydrogenase activation and kinase expression in human skeletal muscle during fasting."J. Appl. Physiol. 96:2082-2087(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Diverging regulation of pyruvate dehydrogenase kinase isoform gene expression in cultured human muscle cells."FEBS J. 272:3004-3014(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta."J. Mol. Biol. 372:341-355(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation."Genes Dev. 25:1716-1733(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Butyrate elicits a metabolic switch in human colon cancer cells by targeting the pyruvate dehydrogenase complex."Int. J. Cancer 128:2591-2601(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Mitochondrial regulators of fatty acid metabolism reflect metabolic dysfunction in type 2 diabetes mellitus."Metabolism 61:175-185(2012) [PubMed] [Europe PMC] [Abstract]
  10. "Pyruvate dehydrogenase kinase-4 structures reveal a metastable open conformation fostering robust core-free basal activity."J. Biol. Chem. 283:25305-25315(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4."Acta Crystallogr. D 67:763-773(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]