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Chemokine C-C-Motif Receptor 2 (CCR2)

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CD192; CC-CKR2; CCR2A; C-C CKR-2; CCR2B; CKR2-A; CKR2-B; CMKBR2; MCP1-R; Monocyte chemoattractant protein 1 receptor

Chemokine C-C-Motif Receptor 2 (CCR2)
CCC A914
HGNC 1603
MGI 106185
PubMed 22615942
RGD 620876
UniProt P41597
Wiki CCR2

CCR2, short for chemokine (C-C motif) receptor 2, is a chemokine receptor. CCR2 has also recently been designated CD192 . This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis.

Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA914Hu01 Recombinant Chemokine C-C-Motif Receptor 2 (CCR2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA914Hu01 Polyclonal Antibody to Chemokine C-C-Motif Receptor 2 (CCR2) WB; IHC; ICC; IP.
MAA914Hu22 Monoclonal Antibody to Chemokine C-C-Motif Receptor 2 (CCR2) WB; IHC; ICC; IP.
Assay Kits SEA914Hu ELISA Kit for Chemokine C-C-Motif Receptor 2 (CCR2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chemokine C-C-Motif Receptor 2 (CCR2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chemokine C-C-Motif Receptor 2 (CCR2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chemokine C-C-Motif Receptor 2 (CCR2) Polyclonal Antibody Customized Service Offer
Assay Kits SEA914Mu ELISA Kit for Chemokine C-C-Motif Receptor 2 (CCR2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chemokine C-C-Motif Receptor 2 (CCR2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chemokine C-C-Motif Receptor 2 (CCR2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chemokine C-C-Motif Receptor 2 (CCR2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chemokine C-C-Motif Receptor 2 (CCR2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chemokine C-C-Motif Receptor 2 (CCR2) ELISA Kit Customized Service Offer
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  9. "HIV-1 Tat protein mimicry of chemokines."Proc. Natl. Acad. Sci. U.S.A. 95:13153-13158(1998) [PubMed] [Europe PMC] [Abstract]
  10. "Monocyte chemotactic protein-1 receptor CCR2B is a glycoprotein that has tyrosine sulfation in a conserved extracellular N-terminal region."J. Immunol. 165:5295-5303(2000) [PubMed] [Europe PMC] [Abstract]
  11. "Human LZIP induces monocyte CC chemokine receptor 2 expression leading to enhancement of monocyte chemoattractant protein 1/CCL2-induced cell migration."Exp. Mol. Med. 40:332-338(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Tyrosine sulfation of chemokine receptor CCR2 enhances interactions with both monomeric and dimeric forms of the chemokine monocyte chemoattractant protein-1 (MCP-1)."J. Biol. Chem. 288:10024-10034(2013) [PubMed] [Europe PMC] [Abstract]
  13. "Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression."Science 277:959-965(1997) [PubMed] [Europe PMC] [Abstract]
  14. "Genealogy of the CCR5 locus and chemokine system gene variants associated with altered rates of HIV-1 disease progression."Nat. Med. 4:786-793(1998) [PubMed] [Europe PMC] [Abstract]