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Chemokine C-C-Motif Receptor 3 (CCR3)

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CD193; CC-CKR3; C-C CKR-3; CMKBR3; CKR3; Eosinophil eotaxin receptor

Chemokine C-C-Motif Receptor 3 (CCR3)
CCC A910
HGNC 1604
MGI 104616
PubMed 15814620
RGD 620593
UniProt P51677
Wiki CCR3_(gene

CCR3 is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants encoding the same protein have been described.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA910Hu01 Recombinant Chemokine C-C-Motif Receptor 3 (CCR3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA910Hu01 Polyclonal Antibody to Chemokine C-C-Motif Receptor 3 (CCR3) WB; IHC; ICC; IP.
MAA910Hu22 Monoclonal Antibody to Chemokine C-C-Motif Receptor 3 (CCR3) WB; IHC; ICC; IP.
Assay Kits SEA910Hu ELISA Kit for Chemokine C-C-Motif Receptor 3 (CCR3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chemokine C-C-Motif Receptor 3 (CCR3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chemokine C-C-Motif Receptor 3 (CCR3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chemokine C-C-Motif Receptor 3 (CCR3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chemokine C-C-Motif Receptor 3 (CCR3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chemokine C-C-Motif Receptor 3 (CCR3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chemokine C-C-Motif Receptor 3 (CCR3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chemokine C-C-Motif Receptor 3 (CCR3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chemokine C-C-Motif Receptor 3 (CCR3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chemokine C-C-Motif Receptor 3 (CCR3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chemokine C-C-Motif Receptor 3 (CCR3) ELISA Kit Customized Service Offer
  1. "Cloning and functional expression of a human eosinophil CC chemokine receptor."J. Biol. Chem. 270:16491-16494(1995) [PubMed] [Europe PMC] [Abstract]
  2. ErratumJ. Biol. Chem. 270:30235-30235(1995)
  3. "Cloning, expression, and characterization of the human eosinophil eotaxin receptor."J. Exp. Med. 183:2349-2354(1996) [PubMed] [Europe PMC] [Abstract]
  4. "Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils."J. Exp. Med. 183:2437-2448(1996) [PubMed] [Europe PMC] [Abstract]
  5. "New variations of human CC-chemokine receptors CCR3 and CCR4."Genes Immun. 1:97-104(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Transcription regulation of human chemokine receptor CCR3: evidence for a rare TATA-less promoter structure conserved between Drosophila and humans."Genomics 80:86-95(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  10. "HIV-1 Tat protein mimicry of chemokines."Proc. Natl. Acad. Sci. U.S.A. 95:13153-13158(1998) [PubMed] [Europe PMC] [Abstract]
  11. "Increased expression of chemokine receptor CCR3 and its ligands in ulcerative colitis: the role of colonic epithelial cells in in vitro studies."Clin. Exp. Immunol. 162:337-347(2010) [PubMed] [Europe PMC] [Abstract]