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Pulmonary Surfactant Associated Protein A1 (SFTPA1)

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PRL; SFTPA; PSAP; PSPA; SFTP; SPA; COLEC4; PSP-A; SFTP1; SFTPA1B; SP-A1; Collectin-4; Alveolar proteinosis protein; 35 kDa pulmonary surfactant-associated protein; Surfactant Associated Protein A

Pulmonary Surfactant Associated Protein A1 (SFTPA1)
CCC A890
HGNC 10798
MGI 109518
PubMed 11149893
RGD 3665
UniProt Q8IWL2
Wiki Sftp1

SP-A (PRL) is a peptide hormone primarily associated with lactation. In breastfeeding, the infant suckling the teat stimulates the production of SP-A, which fills the breast with milk (lactogenesis) in preparation for the next feed. Oxytocin, a similar hormone, is also released, which triggers milk let-down. SP-A (PRL) is a polypeptide hormone secreted by anterior pituitary of both male and female. Release of SP-A is controlled by a complex neuroendocrine reflex initiated by a tactile stimulus and regulated by hypothalamic releasing and inhibition. Genetic variations in SFTPA1 are associated with respiratory distress syndrome in premature infants (RDS) ; also known as RDS in prematurity. RDS in the newborn is the main cause of mortality and morbidity in premature infants.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA890Hu02 Recombinant Pulmonary Surfactant Associated Protein A1 (SFTPA1) Positive Control; Immunogen; SDS-PAGE; WB.
EPA890Hu61 Eukaryotic Pulmonary Surfactant Associated Protein A1 (SFTPA1) Positive Control; Immunogen; SDS-PAGE; WB.
APA890Hu61 Active Pulmonary Surfactant Associated Protein A1 (SFTPA1) Cell culture; Activity Assays.
RPA890Hu01 Recombinant Pulmonary Surfactant Associated Protein A1 (SFTPA1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAA890Hu22 Monoclonal Antibody to Pulmonary Surfactant Associated Protein A1 (SFTPA1) WB; IHC
LAA890Hu81 FITC-Linked Polyclonal Antibody to Pulmonary Surfactant Associated Protein A1 (SFTPA1) WB; IHC; ICC; IF.
LAA890Hu71 Biotin-Linked Polyclonal Antibody to Pulmonary Surfactant Associated Protein A1 (SFTPA1) WB; IHC; ICC.
PAA890Hu02 Polyclonal Antibody to Pulmonary Surfactant Associated Protein A1 (SFTPA1) WB; IHC
PAA890Hu01 Polyclonal Antibody to Pulmonary Surfactant Associated Protein A1 (SFTPA1) Testing in progress
MAA890Hu21 Monoclonal Antibody to Pulmonary Surfactant Associated Protein A1 (SFTPA1) WB
MAA890Hu23 Monoclonal Antibody to Pulmonary Surfactant Associated Protein A1 (SFTPA1) WB; IHC; ICC; IP.
Assay Kits SEA890Hu ELISA Kit for Pulmonary Surfactant Associated Protein A1 (SFTPA1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA890Hu CLIA Kit for Pulmonary Surfactant Associated Protein A1 (SFTPA1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA890Mu01 Recombinant Pulmonary Surfactant Associated Protein A1 (SFTPA1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA890Mu02 Recombinant Pulmonary Surfactant Associated Protein A1 (SFTPA1) Positive Control; Immunogen; SDS-PAGE; WB.
EPA890Mu61 Eukaryotic Pulmonary Surfactant Associated Protein A1 (SFTPA1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA890Mu03 Recombinant Pulmonary Surfactant Associated Protein A1 (SFTPA1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA890Mu04 Recombinant Pulmonary Surfactant Associated Protein A1 (SFTPA1) Positive Control; Immunogen; SDS-PAGE; WB.
APA890Mu61 Active Pulmonary Surfactant Associated Protein A1 (SFTPA1) Cell culture; Activity Assays.
Antibodies PAA890Mu01 Polyclonal Antibody to Pulmonary Surfactant Associated Protein A1 (SFTPA1) WB
PAA890Mu02 Polyclonal Antibody to Pulmonary Surfactant Associated Protein A1 (SFTPA1) WB; IHC; ICC; IP.
Assay Kits SEA890Mu ELISA Kit for Pulmonary Surfactant Associated Protein A1 (SFTPA1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA890Ra01 Recombinant Pulmonary Surfactant Associated Protein A1 (SFTPA1) Positive Control; Immunogen; SDS-PAGE; WB.
EPA890Ra61 Eukaryotic Pulmonary Surfactant Associated Protein A1 (SFTPA1) Positive Control; Immunogen; SDS-PAGE; WB.
APA890Ra61 Active Pulmonary Surfactant Associated Protein A1 (SFTPA1) Cell culture; Activity Assays.
Antibodies PAA890Ra01 Polyclonal Antibody to Pulmonary Surfactant Associated Protein A1 (SFTPA1) WB; IHC
MAA890Ra21 Monoclonal Antibody to Pulmonary Surfactant Associated Protein A1 (SFTPA1) WB; IHC; ICC; IP.
Assay Kits SEA890Ra ELISA Kit for Pulmonary Surfactant Associated Protein A1 (SFTPA1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA890Ca01 Recombinant Pulmonary Surfactant Associated Protein A1 (SFTPA1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA890Ca01 Polyclonal Antibody to Pulmonary Surfactant Associated Protein A1 (SFTPA1) WB; IHC; ICC; IP.
MAA890Ca21 Monoclonal Antibody to Pulmonary Surfactant Associated Protein A1 (SFTPA1) WB; IHC; ICC; IP.
Assay Kits SEA890Ca ELISA Kit for Pulmonary Surfactant Associated Protein A1 (SFTPA1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA890Po01 Recombinant Pulmonary Surfactant Associated Protein A1 (SFTPA1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA890Po01 Polyclonal Antibody to Pulmonary Surfactant Associated Protein A1 (SFTPA1) WB; IHC; ICC; IP.
MAA890Po21 Monoclonal Antibody to Pulmonary Surfactant Associated Protein A1 (SFTPA1) WB; IHC; ICC; IP.
Assay Kits SEA890Po ELISA Kit for Pulmonary Surfactant Associated Protein A1 (SFTPA1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Isolation and characterization of the human pulmonary surfactant apoprotein gene."Nature 317:361-363(1985) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation and characterization of cDNA clones for the 35-kDa pulmonary surfactant-associated protein."J. Biol. Chem. 261:9029-9033(1986) [PubMed] [Europe PMC] [Abstract]
  3. "Human SP-A1 (SFTPA1) variant-specific 3' UTRs and poly(A) tail differentially affect the in vitro translation of a reporter gene."Am. J. Physiol. 299:L523-L534(2010) [PubMed] [Europe PMC] [Abstract]
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  8. "Genetics of the hydrophilic surfactant proteins A and D."Biochim. Biophys. Acta 1408:312-322(1998) [PubMed] [Europe PMC] [Abstract]
  9. "Association between the surfactant protein A (SP-A) gene locus and respiratory-distress syndrome in the Finnish population."Am. J. Hum. Genet. 66:1569-1579(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Surfactant protein A and B genetic variants predispose to idiopathic pulmonary fibrosis."Hum. Genet. 113:542-550(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Genetic defects in surfactant protein A2 are associated with pulmonary fibrosis and lung cancer."Am. J. Hum. Genet. 84:52-59(2009) [PubMed] [Europe PMC] [Abstract]
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