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Complement Component 2 (C2)

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CO2; C3/C5 convertase

Complement Component 2 (C2)
CCC A862
HGNC 1248
MGI 88226
PubMed 16518403
RGD 2231
UniProt P06681
Wiki C2

Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA862Hu01 Recombinant Complement Component 2 (C2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA862Hu01 Polyclonal Antibody to Complement Component 2 (C2) WB,IHC
MAA862Hu22 Monoclonal Antibody to Complement Component 2 (C2) WB; IHC; ICC; IP.
Assay Kits SEA862Hu ELISA Kit for Complement Component 2 (C2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Complement Component 2 (C2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Complement Component 2 (C2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Complement Component 2 (C2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Complement Component 2 (C2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Complement Component 2 (C2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA862Ra01 Recombinant Complement Component 2 (C2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA862Ra01 Polyclonal Antibody to Complement Component 2 (C2) WB; IHC; ICC; IP.
MAA862Ra21 Monoclonal Antibody to Complement Component 2 (C2) WB; IHC; ICC; IP.
Assay Kits SEA862Ra ELISA Kit for Complement Component 2 (C2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Primary structure of human complement component C2. Homology to two unrelated protein families."Biochem. J. 239:339-345(1986) [PubMed] [Europe PMC] [Abstract]
  2. "cDNA cloning and expression of human complement component C2."J. Immunol. 142:2105-2111(1989) [PubMed] [Europe PMC] [Abstract]
  3. "Structure of the human C2 gene."J. Immunol. 151:170-174(1993) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The purification and properties of the second component of guinea-pig complement."Biochem. J. 205:59-67(1982) [PubMed] [Europe PMC] [Abstract]
  8. "DNA polymorphism of the C2 locus."Immunogenetics 22:377-390(1985) [PubMed] [Europe PMC] [Abstract]
  9. "A Schistosoma protein, Sh-TOR, is a novel inhibitor of complement which binds human C2."FEBS Lett. 470:131-134(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Structure and activation of complement components C2 and factor B."Philos. Trans. R. Soc. Lond., B, Biol. Sci. 306:301-309(1984) [PubMed] [Europe PMC] [Abstract]
  11. "The reaction of iodine and thiol-blocking reagents with human complement components C2 and factor B. Purification and N-terminal amino acid sequence of a peptide from C2a containing a free thiol group."Biochem. J. 213:201-209(1983) [PubMed] [Europe PMC] [Abstract]
  12. "Isolation of cDNA clones for human complement component C2."Proc. Natl. Acad. Sci. U.S.A. 81:1212-1215(1984) [PubMed] [Europe PMC] [Abstract]
  13. "Cell-specific expression of the human complement protein factor B gene: evidence for the role of two distinct 5'-flanking elements."Cell 48:331-342(1987) [PubMed] [Europe PMC] [Abstract]
  14. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Structure of complement component C2A: implications for convertase formation and substrate binding."Structure 14:1587-1597(2006) [PubMed] [Europe PMC] [Abstract]
  18. "The structure of C2b, a fragment of complement component C2 produced during C3 convertase formation."Acta Crystallogr. D 65:266-274(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Type II human complement C2 deficiency. Allele-specific amino acid substitutions (Ser189 --> Phe; Gly444 --> Arg) cause impaired C2 secretion."J. Biol. Chem. 271:5824-5831(1996) [PubMed] [Europe PMC] [Abstract]
  20. "A novel type II complement C2 deficiency allele in an African-American family."J. Immunol. 161:578-584(1998) [PubMed] [Europe PMC] [Abstract]
  21. "Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration."Nat. Genet. 38:458-462(2006) [PubMed] [Europe PMC] [Abstract]