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Glycogen Phosphorylase, Brain (PYGB)

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GPBB

Glycogen Phosphorylase, Brain (PYGB)
CCC A845
HGNC 9723
MGI 97828
PubMed 2615594
RGD 3460
UniProt P11216

PYGB is a new isozyme of glycogen phosphorylase (1,4-D-glucan:orthosphosphate D-glucosyltransferase; EC 2.4.1.1) from a cDNA library prepared from a human brain astrocytoma cell line. Blot-hybridization analysis showed that the message is preferentially expressed in human brain, but is also found at a low level in human fetal liver and adult liver and muscle tissues. The protein sequence deduced from the nucleotide sequence was 862 amino acids long compared with 846 and 841 amino acids for the liver (PYGL) and muscle (PYGM) isozymes, respectively. The greater length of brain phosphorylase was found to be due entirely to an extension at the c-terminal portion of the protein. Muscle and brain isozymes shared greater similarities with each other than either did with the liver sequence.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA845Hu01 Recombinant Glycogen Phosphorylase, Brain (PYGB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA845Hu01 Polyclonal Antibody to Glycogen Phosphorylase, Brain (PYGB) WB,IHC
Assay Kits n/a CLIA Kit for Glycogen Phosphorylase, Brain (PYGB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glycogen Phosphorylase, Brain (PYGB) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA845Mu01 Recombinant Glycogen Phosphorylase, Brain (PYGB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA845Mu01 Polyclonal Antibody to Glycogen Phosphorylase, Brain (PYGB) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Glycogen Phosphorylase, Brain (PYGB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glycogen Phosphorylase, Brain (PYGB) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glycogen Phosphorylase, Brain (PYGB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glycogen Phosphorylase, Brain (PYGB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glycogen Phosphorylase, Brain (PYGB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glycogen Phosphorylase, Brain (PYGB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glycogen Phosphorylase, Brain (PYGB) ELISA Kit Customized Service Offer
  1. "Human brain glycogen phosphorylase. Cloning, sequence analysis, chromosomal mapping, tissue expression, and comparison with the human liver and muscle isozymes."J. Biol. Chem. 263:3850-3857(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Human brain glycogen phosphorylase: characterization of fetal cDNA and genomic sequences."Brain Res. Mol. Brain Res. 6:177-185(1989) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  6. , Submitted (JUL-2007) to UniProtKB
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]