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Lipoprotein, a (Lpa)

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Lp(a); AK38; APOA; LP; Sinking Pre-β-Lipoprotein

Lipoprotein, a (Lpa)
CCC A842
HGNC 6667
PubMed 20965889
UniProt P08519
Wiki Lpa

Lipoprotein(a) consists of an LDL-like particle and the specific apolipoprotein(a) , which is covalently bound to the apoB of the LDL like particle. Lp(a) plasma concentrations are highly heritable and mainly controlled by the apolipoprotein(a) gene located on chromosome 6q26-27. Apo(a) proteins vary in size due to a size polymorphism , which is caused by a variable number of so called kringle IV repeats in the LPA gene. This size variation at the gene level is expressed on the protein level as well, resulting in apo(a) proteins with 10 to > 50 kringle IV repeats . These variable apo(a) sizes are known as "apo(a) isoforms". There is a general inverse correlation between the size of the apo(a)isoform and the Lp(a) plasma concentration which is caused by a variable rate of degradation before the apo(a) protein has matured for Lp(a) assembly.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA842Hu01 Recombinant Lipoprotein, a (Lpa) Positive Control; Immunogen; SDS-PAGE; WB.
APA842Hu01 Active Lipoprotein, a (Lpa) Cell culture; Activity Assays.
Antibodies PAA842Hu01 Polyclonal Antibody to Lipoprotein, a (Lpa) WB; IHC; ICC; IP.
MAA842Hu22 Monoclonal Antibody to Lipoprotein, a (Lpa) WB; IHC; ICC; IP.
Assay Kits SEA842Hu ELISA Kit for Lipoprotein, a (Lpa) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lipoprotein, a (Lpa) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lipoprotein, a (Lpa) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lipoprotein, a (Lpa) Polyclonal Antibody Customized Service Offer
Assay Kits SEA842Mu ELISA Kit for Lipoprotein, a (Lpa) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lipoprotein, a (Lpa) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lipoprotein, a (Lpa) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lipoprotein, a (Lpa) Polyclonal Antibody Customized Service Offer
Assay Kits SEA842Rb ELISA Kit for Lipoprotein, a (Lpa) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "cDNA sequence of human apolipoprotein(a) is homologous to plasminogen."Nature 330:132-137(1987) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Amplification of human APO(a) kringle 4-37 from blood lymphocyte DNA."Biochim. Biophys. Acta 1225:107-109(1993) [PubMed] [Europe PMC] [Abstract]
  4. "Lipoprotein(a) binds to fibronectin and has serine proteinase activity capable of cleaving it."EMBO J. 8:4035-4040(1989) [PubMed] [Europe PMC] [Abstract]
  5. "The mysteries of lipoprotein(a)."Science 246:904-910(1989) [PubMed] [Europe PMC] [Abstract]
  6. "Structural elucidation of the N- and O-glycans of human apolipoprotein(a): role of o-glycans in conferring protease resistance."J. Biol. Chem. 276:22200-22208(2001) [PubMed] [Europe PMC] [Abstract]
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  8. "Crystal structures of apolipoprotein(a) kringle IV37 free and complexed with 6-aminohexanoic acid and with p-aminomethylbenzoic acid: existence of novel and expected binding modes."J. Mol. Biol. 256:751-761(1996) [PubMed] [Europe PMC] [Abstract]
  9. "A single point mutation (Trp72-->Arg) in human apo(a) kringle 4-37 associated with a lysine binding defect in Lp(a)."Biochim. Biophys. Acta 1227:41-45(1994) [PubMed] [Europe PMC] [Abstract]