Coagulation Factor IX (F9)
[Edit]HEMB; FIX; GLA Domain; PTC; Anti Hemophilic Factor B; Christmas Factor; Plasma Thromboplastic Component; Christmas Disease; Hemophilia B
![Coagulation Factor IX (F9)](/upload/item/img/Coagulation-Factor-IX-(F9)-90840.jpg)
Factor IX is one of the serine proteases (EC 3.4.21.22) of the coagulation system; it belongs to peptidase family S1. Deficiency of this protein causes hemophilia B. It was discovered after a young boy named Stephen Christmas was found to be lacking this exact factor, leading to hemophilia, in 1952. Factor IX is inactive unless activated by factor XIa (of the contact pathway) or factor VIIa (of the tissue factor pathway). When activated into factor IXa, in the presence of Ca2+, membrane phospholipids, and a Factor VIII cofactor, it hydrolyses one arginine-isoleucine bond in factor X to form factor Xa.Deficiency of factor IX causes Christmas disease (hemophilia B). Over 100 mutations of factor IX have been described; some cause no symptoms, but many lead to a significant bleeding disorder.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA840Hu01 | Recombinant Coagulation Factor IX (F9) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAA840Hu01 | Polyclonal Antibody to Coagulation Factor IX (F9) | WB; IHC; ICC; IP. |
MAA840Hu22 | Monoclonal Antibody to Coagulation Factor IX (F9) | WB | |
LAA840Hu91 | HRP-Linked Polyclonal Antibody to Coagulation Factor IX (F9) | WB; IHC; ICC. | |
MAA840Hu21 | Monoclonal Antibody to Coagulation Factor IX (F9) | WB | |
MAA840Hu23 | Monoclonal Antibody to Coagulation Factor IX (F9) | WB; IHC; ICC; IP. | |
Assay Kits | SEA840Hu | ELISA Kit for Coagulation Factor IX (F9) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA840Mu01 | Recombinant Coagulation Factor IX (F9) | Positive Control; Immunogen; SDS-PAGE; WB. |
RPA840Mu02 | Recombinant Coagulation Factor IX (F9) | Positive Control; Immunogen; SDS-PAGE; WB. | |
Antibodies | PAA840Mu01 | Polyclonal Antibody to Coagulation Factor IX (F9) | WB; IHC; ICC; IP. |
PAA840Mu02 | Polyclonal Antibody to Coagulation Factor IX (F9) | WB; IHC; ICC; IP. | |
Assay Kits | SEA840Mu | ELISA Kit for Coagulation Factor IX (F9) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA840Ra01 | Recombinant Coagulation Factor IX (F9) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAA840Ra01 | Polyclonal Antibody to Coagulation Factor IX (F9) | WB; IHC; ICC; IP. |
MAA840Ra21 | Monoclonal Antibody to Coagulation Factor IX (F9) | WB; IHC; ICC; IP. | |
Assay Kits | SEA840Ra | ELISA Kit for Coagulation Factor IX (F9) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Oryctolagus cuniculus (Rabbit)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA840Rb01 | Recombinant Coagulation Factor IX (F9) | Positive Control; Immunogen; SDS-PAGE; WB. |
RPA840Rb02 | Recombinant Coagulation Factor IX (F9) | Positive Control; Immunogen; SDS-PAGE; WB. | |
RPA840Rb03 | Recombinant Coagulation Factor IX (F9) | Positive Control; Immunogen; SDS-PAGE; WB. | |
APA840Rb03 | Active Coagulation Factor IX (F9) | Cell culture; Activity Assays. | |
Antibodies | PAA840Rb51 | Polyclonal Antibody to Coagulation Factor IX (F9) | WB; IHC; ICC; IP. |
LAA840Rb71 | Biotin-Linked Polyclonal Antibody to Coagulation Factor IX (F9) | WB; IHC; ICC. | |
MAA840Rb21 | Monoclonal Antibody to Coagulation Factor IX (F9) | WB | |
MAA840Rb22 | Monoclonal Antibody to Coagulation Factor IX (F9) | WB; IHC; ICC; IP. | |
Assay Kits | n/a | CLIA Kit for Coagulation Factor IX (F9) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Coagulation Factor IX (F9) | ELISA Kit Customized Service Offer |
Organism species: Bos taurus; Bovine (Cattle)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA840Bo01 | Recombinant Coagulation Factor IX (F9) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAA840Bo01 | Polyclonal Antibody to Coagulation Factor IX (F9) | WB; IHC; ICC; IP. |
LAA840Bo71 | Biotin-Linked Polyclonal Antibody to Coagulation Factor IX (F9) | WB; IHC; ICC. | |
Assay Kits | n/a | CLIA Kit for Coagulation Factor IX (F9) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Coagulation Factor IX (F9) | ELISA Kit Customized Service Offer |
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- "Crystal structure of the calcium-stabilized human factor IX Gla domain bound to a conformation-specific anti-factor IX antibody."J. Biol. Chem. 279:14338-14346(2004) [PubMed] [Europe PMC] [Abstract]
- "Structural basis of the cofactor- and substrate-assisted activation of human coagulation factor IXa."Structure 17:1669-1678(2009) [PubMed] [Europe PMC] [Abstract]
- "Studies of benzothiophene template as potent factor IXa (FIXa) inhibitors in thrombosis."J. Med. Chem. 53:1465-1472(2010) [PubMed] [Europe PMC] [Abstract]
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