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B-Cell Leukemia/Lymphoma 2 (Bcl2)

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B-Cell CLL/Lymphoma 2

B-Cell Leukemia/Lymphoma 2 (Bcl2)
CCC A778
HGNC 990
MGI 88138
PubMed 9735050
RGD 2199
UniProt P10415
Wiki Bcl-2

Bcl-2) was one of the first oncogenic proteins discovered to inhibit apoptosis. The Bcl-2 family of proteins plays a crucial role in the regulation of cell death in many eukaryotic systems. Bcl-2 is a 26 kD protein associated with cell survival.

Bcl-2 is localized within the outer mitochondrial membrane, endoplasmic reticulum, and the nuclear envelope, where it exerts cell survival functions within many cell types. These functions include ion-conducting channel formation, integral protection from cytotoxic agents, inhibition of proteins that activate caspases responsible for disassembling cells, as well as the ability to modulate cell cycle initiation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA778Hu01 Recombinant B-Cell Leukemia/Lymphoma 2 (Bcl2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA778Hu01 Polyclonal Antibody to B-Cell Leukemia/Lymphoma 2 (Bcl2) WB,IHC,ICC/IF
MAA778Hu22 Monoclonal Antibody to B-Cell Leukemia/Lymphoma 2 (Bcl2) WB; IHC; ICC; IP.
LAA778Hu71 Biotin-Linked Polyclonal Antibody to B-Cell Leukemia/Lymphoma 2 (Bcl2) WB; IHC; ICC.
LAA778Hu81 FITC-Linked Polyclonal Antibody to B-Cell Leukemia/Lymphoma 2 (Bcl2) WB; IHC; ICC; IF.
MAA778Hu21 Monoclonal Antibody to B-Cell Leukemia/Lymphoma 2 (Bcl2) WB; IHC; ICC; IP.
MAA778Hu23 Monoclonal Antibody to B-Cell Leukemia/Lymphoma 2 (Bcl2) WB; IHC; ICC; IP.
MAA778Hu24 Monoclonal Antibody to B-Cell Leukemia/Lymphoma 2 (Bcl2) WB; IHC; ICC; IP.
MAA778Hu25 Monoclonal Antibody to B-Cell Leukemia/Lymphoma 2 (Bcl2) WB; IHC; ICC; IP.
Assay Kits SEA778Hu ELISA Kit for B-Cell Leukemia/Lymphoma 2 (Bcl2) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA778Hu CLIA Kit for B-Cell Leukemia/Lymphoma 2 (Bcl2) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA778Mu01 Recombinant B-Cell Leukemia/Lymphoma 2 (Bcl2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA778Mu02 Recombinant B-Cell Leukemia/Lymphoma 2 (Bcl2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA778Mu01 Polyclonal Antibody to B-Cell Leukemia/Lymphoma 2 (Bcl2) WB; IHC; ICC/IF
LAA778Mu71 Biotin-Linked Polyclonal Antibody to B-Cell Leukemia/Lymphoma 2 (Bcl2) WB; IHC; ICC.
LAA778Mu81 FITC-Linked Polyclonal Antibody to B-Cell Leukemia/Lymphoma 2 (Bcl2) WB; IHC; ICC; IF.
PAA778Mu02 Polyclonal Antibody to B-Cell Leukemia/Lymphoma 2 (Bcl2) WB; IHC; ICC; IP.
Assay Kits SEA778Mu ELISA Kit for B-Cell Leukemia/Lymphoma 2 (Bcl2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA778Ra01 Recombinant B-Cell Leukemia/Lymphoma 2 (Bcl2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA778Ra01 Polyclonal Antibody to B-Cell Leukemia/Lymphoma 2 (Bcl2) WB; IHC; ICC; IP.
LAA778Ra81 FITC-Linked Polyclonal Antibody to B-Cell Leukemia/Lymphoma 2 (Bcl2) WB; IHC; ICC; IF.
MAA778Ra21 Monoclonal Antibody to B-Cell Leukemia/Lymphoma 2 (Bcl2) WB; IHC; ICC; IP.
Assay Kits SEA778Ra ELISA Kit for B-Cell Leukemia/Lymphoma 2 (Bcl2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant B-Cell Leukemia/Lymphoma 2 (Bcl2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to B-Cell Leukemia/Lymphoma 2 (Bcl2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to B-Cell Leukemia/Lymphoma 2 (Bcl2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for B-Cell Leukemia/Lymphoma 2 (Bcl2) CLIA Kit Customized Service Offer
n/a ELISA Kit for B-Cell Leukemia/Lymphoma 2 (Bcl2) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA778Po01 Recombinant B-Cell Leukemia/Lymphoma 2 (Bcl2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA778Po01 Polyclonal Antibody to B-Cell Leukemia/Lymphoma 2 (Bcl2) WB; IHC; ICC; IP.
Assay Kits SEA778Po ELISA Kit for B-Cell Leukemia/Lymphoma 2 (Bcl2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA778Bo01 Recombinant B-Cell Leukemia/Lymphoma 2 (Bcl2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA778Bo01 Polyclonal Antibody to B-Cell Leukemia/Lymphoma 2 (Bcl2) WB; IHC; ICC; IP.
MAA778Bo21 Monoclonal Antibody to B-Cell Leukemia/Lymphoma 2 (Bcl2) WB; IHC; ICC; IP.
Assay Kits SEA778Bo ELISA Kit for B-Cell Leukemia/Lymphoma 2 (Bcl2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Ovis aries; Ovine (Sheep)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant B-Cell Leukemia/Lymphoma 2 (Bcl2) Recombinant Protein Customized Service Offer
Antibodies PAA778Ov01 Polyclonal Antibody to B-Cell Leukemia/Lymphoma 2 (Bcl2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for B-Cell Leukemia/Lymphoma 2 (Bcl2) CLIA Kit Customized Service Offer
n/a ELISA Kit for B-Cell Leukemia/Lymphoma 2 (Bcl2) ELISA Kit Customized Service Offer
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  2. "Isolation and characterization of the chicken bcl-2 gene: expression in a variety of tissues including lymphoid and neuronal organs in adult and embryo."Nucleic Acids Res. 20:4187-4192(1992) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation."Cell 47:19-28(1986) [PubMed] [Europe PMC] [Abstract]
  4. "Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma."EMBO J. 7:123-131(1988) [PubMed] [Europe PMC] [Abstract]
  5. "Consequences of the t(14;18) chromosomal translocation in follicular lymphoma: deregulated expression of a chimeric and mutated BCL-2 gene."Oncogene Res. 2:263-275(1988) [PubMed] [Europe PMC] [Abstract]
  6. "DNA sequence and analysis of human chromosome 18." Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Frequent incidence of somatic mutations in translocated BCL2 oncogenes of non-Hodgkin's lymphomas."Blood 79:229-237(1992) [PubMed] [Europe PMC] [Abstract]
  9. "Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death."Nature 348:334-336(1990) [PubMed] [Europe PMC] [Abstract]
  10. "BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax."Nature 369:321-323(1994) [PubMed] [Europe PMC] [Abstract]
  11. "BAG-1 modulates the chaperone activity of Hsp70/Hsc70."EMBO J. 16:4887-4896(1997) [PubMed] [Europe PMC] [Abstract]
  12. "Conversion of Bcl-2 to a Bax-like death effector by caspases."Science 278:1966-1968(1997) [PubMed] [Europe PMC] [Abstract]
  13. "The p53-binding protein 53BP2 also interacts with Bcl2 and impedes cell cycle progression at G2/M."Mol. Cell. Biol. 16:3884-3892(1996) [PubMed] [Europe PMC] [Abstract]
  14. "Phosphorylation of Bcl2 and regulation of apoptosis."Leukemia 15:515-522(2001) [PubMed] [Europe PMC] [Abstract]
  15. "BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M."Mol. Cell. Biol. 19:8469-8478(1999) [PubMed] [Europe PMC] [Abstract]
  16. "PUMA induces the rapid apoptosis of colorectal cancer cells."Mol. Cell 7:673-682(2001) [PubMed] [Europe PMC] [Abstract]
  17. "BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis."Biochem. Biophys. Res. Commun. 308:379-385(2003) [PubMed] [Europe PMC] [Abstract]
  18. "The flexible loop of Bcl-2 is required for molecular interaction with immunosuppressant FK-506 binding protein 38 (FKBP38)."FEBS Lett. 579:1469-1476(2005) [PubMed] [Europe PMC] [Abstract]
  19. "p21-activated Kinase 1 (Pak1)-dependent phosphorylation of Raf-1 regulates its mitochondrial localization, phosphorylation of BAD, and Bcl-2 association."J. Biol. Chem. 280:24698-24705(2005) [PubMed] [Europe PMC] [Abstract]
  20. "BMRP is a Bcl-2 binding protein that induces apoptosis."J. Cell. Biochem. 94:611-626(2005) [PubMed] [Europe PMC] [Abstract]
  21. "Bcl-2 localized at the nuclear compartment induces apoptosis after transient overexpression."J. Biol. Chem. 281:40493-40502(2006) [PubMed] [Europe PMC] [Abstract]
  22. "JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy."Mol. Cell 30:678-688(2008) [PubMed] [Europe PMC] [Abstract]
  23. "Identification of a protein, G0S2, that lacks Bcl-2 homology domains and interacts with and antagonizes Bcl-2."Cancer Res. 69:6782-6789(2009) [PubMed] [Europe PMC] [Abstract]
  24. "Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect."J. Biol. Chem. 284:9692-9699(2009) [PubMed] [Europe PMC] [Abstract]
  25. "Prolyl hydroxylase 3 interacts with Bcl-2 to regulate doxorubicin-induced apoptosis in H9c2 cells."Biochem. Biophys. Res. Commun. 401:231-237(2010) [PubMed] [Europe PMC] [Abstract]
  26. "Parkin mono-ubiquitinates Bcl-2 and regulates autophagy."J. Biol. Chem. 285:38214-38223(2010) [PubMed] [Europe PMC] [Abstract]
  27. "Human Bop is a novel BH3-only member of the Bcl-2 protein family."Protein Cell 3:790-801(2012) [PubMed] [Europe PMC] [Abstract]
  28. "Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma."Proc. Natl. Acad. Sci. U.S.A. 110:3943-3948(2013) [PubMed] [Europe PMC] [Abstract]
  29. "Solution structure of the antiapoptotic protein bcl-2."Proc. Natl. Acad. Sci. U.S.A. 98:3012-3017(2001) [PubMed] [Europe PMC] [Abstract]
  30. "An inhibitor of Bcl-2 family proteins induces regression of solid tumours." Nature 435:677-681(2005) [PubMed] [Europe PMC] [Abstract]
  31. "Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL." J. Med. Chem. 50:641-662(2007) [PubMed] [Europe PMC] [Abstract]