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Complement Receptor 2 (CD21)

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CR2; C3DR; Complement Component(3d/Epstein Barr Virus)Receptor 2; Complement C3d receptor; Epstein-Barr virus receptor; EBV receptor

Complement Receptor 2 (CD21)
CCC A750
HGNC 2336
MGI 88489
PubMed 12090564
RGD 1310065
UniProt P20023
Wiki CR2

CR2 and CD21, is a protein involved in the complement system. It binds to iC3b (inactive derivative of C3b), C3dg, or C3d.B cells have CR2 receptors on their surfaces, allowing the complement system to play a role in B-cell activation and maturation .CR2 on mature B cells form a complex with two other membrane proteins, CD19 and CD81(=TAPA-1). The CR2-CD19-CD81 complex is often called the B cell coreceptor complex,[3] because CR2 binds to antigens through attached C3d (or iC3b or C3dg) when the menbrane IgM binds to the antigen. This results in the B cell to have greatly enhanced response to the antigen.Epstein-Barr virus (EBV) binds to B cells at CR2 during infection of these cells. Yefenof et al. (1976) found complete overlapping of EBV receptors and C3 receptors on human B lymphocytes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA750Hu01 Recombinant Complement Receptor 2 (CD21) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA750Hu01 Polyclonal Antibody to Complement Receptor 2 (CD21) WB; IHC; ICC; IP.
MAA750Hu22 Monoclonal Antibody to Complement Receptor 2 (CD21) WB; IHC; ICC; IP.
MAA750Hu21 Monoclonal Antibody to Complement Receptor 2 (CD21) WB; IHC; ICC; IP.
MAA750Hu24 Monoclonal Antibody to Complement Receptor 2 (CD21) WB; IHC; ICC; IP.
MAA750Hu23 Monoclonal Antibody to Complement Receptor 2 (CD21) WB; IHC; ICC; IP.
MAA750Hu25 Monoclonal Antibody to Complement Receptor 2 (CD21) WB; IHC; ICC; IP.
Assay Kits SEA750Hu ELISA Kit for Complement Receptor 2 (CD21) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA750Mu01 Recombinant Complement Receptor 2 (CD21) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA750Mu01 Polyclonal Antibody to Complement Receptor 2 (CD21) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Complement Receptor 2 (CD21) CLIA Kit Customized Service Offer
n/a ELISA Kit for Complement Receptor 2 (CD21) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA750Ra01 Recombinant Complement Receptor 2 (CD21) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA750Ra01 Polyclonal Antibody to Complement Receptor 2 (CD21) WB; IHC; ICC; IP.
MAA750Ra21 Monoclonal Antibody to Complement Receptor 2 (CD21) WB; IHC; ICC; IP.
Assay Kits SEA750Ra ELISA Kit for Complement Receptor 2 (CD21) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Complement Receptor 2 (CD21) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Complement Receptor 2 (CD21) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Complement Receptor 2 (CD21) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Complement Receptor 2 (CD21) CLIA Kit Customized Service Offer
n/a ELISA Kit for Complement Receptor 2 (CD21) ELISA Kit Customized Service Offer
  1. "Genomic organization and polymorphisms of the human C3d/Epstein-Barr virus receptor."J. Biol. Chem. 264:2118-2125(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Structure of the human B lymphocyte receptor for C3d and the Epstein-Barr virus and relatedness to other members of the family of C3/C4 binding proteins."J. Exp. Med. 167:1047-1066(1988) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning of the cDNA encoding the Epstein-Barr virus.C3d receptor (complement receptor type 2) of human b lymphocytes."Proc. Natl. Acad. Sci. U.S.A. 84:9194-9198(1987) [PubMed] [Europe PMC] [Abstract]
  4. "Evidence for a new transcript of the Epstein-Barr virus/C3d receptor (CR2, CD21) which is due to alternative exon usage."Mol. Immunol. 35:1025-1031(1998) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of a partial cDNA clone for the C3d/Epstein-Barr virus receptor of human B lymphocytes: homology with the receptor for fragments C3b and C4b of the third and fourth components of complement."Proc. Natl. Acad. Sci. U.S.A. 83:5639-5643(1986) [PubMed] [Europe PMC] [Abstract]
  9. "Characterization of the EBV/C3d receptor on the human Jurkat T cell line: evidence for a novel transcript."J. Immunol. 150:5311-5320(1993) [PubMed] [Europe PMC] [Abstract]
  10. "Binding sites of the Epstein-Barr virus and C3d receptor (CR2, CD21) for its three intracellular ligands, the p53 anti-oncoprotein, the p68 calcium binding protein and the nuclear p120 ribonucleoprotein."Mol. Immunol. 32:389-397(1995) [PubMed] [Europe PMC] [Abstract]
  11. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Genetic CD21 deficiency is associated with hypogammaglobulinemia." J. Allergy Clin. Immunol. 129:801-810(2012) [PubMed] [Europe PMC] [Abstract]
  13. "Structure of complement receptor 2 in complex with its C3d ligand."Science 292:1725-1728(2001) [PubMed] [Europe PMC] [Abstract]
  14. "The crystal structure of human CD21: Implications for Epstein-Barr virus and C3d binding."Proc. Natl. Acad. Sci. U.S.A. 99:10641-10646(2002) [PubMed] [Europe PMC] [Abstract]
  15. "The 15 SCR flexible extracellular domains of human complement receptor type 2 can mediate multiple ligand and antigen interactions."J. Mol. Biol. 362:1132-1147(2006) [PubMed] [Europe PMC] [Abstract]
  16. "A crystal structure of the complex between human complement receptor 2 and its ligand C3d."Science 332:608-611(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Association of a common complement receptor 2 haplotype with increased risk of systemic lupus erythematosus." Proc. Natl. Acad. Sci. U.S.A. 104:3961-3966(2007) [PubMed] [Europe PMC] [Abstract]