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Cyclin Dependent Kinase 5 (CDK5)

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PSSALRE; CDKN5; Cell division protein kinase 5; Serine/threonine-protein kinase PSSALRE; Tau protein kinase II catalytic subunit;TPKII catalytic subunit

Cyclin Dependent Kinase 5 (CDK5)
CCC A739
HGNC 1774
MGI 101765
PubMed 11584302
RGD 70514
UniProt Q00535
Wiki CDK5

Recently Cdk5 has emerged as an essential kinase in sensory pathways. Recent reports of Pareek et al. from NIH suggest its necessity in pain signaling. CDK5 is required for proper development of the brain and to be activated, CDK5 must associate with CDK5R1 or CDK5R2. Unlike other cyclin dependent kinases, CDK5 does not also require phosphorylation on the T loop so that binding with the activator is sufficient to activate the kinase. Cdk5 is involved in the processes of neuronal maturation and migration, phosphorylating the key intracellular adaptor of the reelin signaling chain.Experiments performed on mice lacking p35, a necessary activator of cdk5 in early brain development, showed that the normal layering of neurons was reversed in the cortex.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA739Hu01 Recombinant Cyclin Dependent Kinase 5 (CDK5) Positive Control; Immunogen; SDS-PAGE; WB.
RPA739Hu02 Recombinant Cyclin Dependent Kinase 5 (CDK5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA739Hu01 Polyclonal Antibody to Cyclin Dependent Kinase 5 (CDK5) WB; IHC; ICC; IP.
LAA739Hu71 Biotin-Linked Polyclonal Antibody to Cyclin Dependent Kinase 5 (CDK5) WB; IHC; ICC.
LAA739Hu81 FITC-Linked Polyclonal Antibody to Cyclin Dependent Kinase 5 (CDK5) WB; IHC; ICC; IF.
MAA739Hu21 Monoclonal Antibody to Cyclin Dependent Kinase 5 (CDK5) WB; IHC; ICC; IP.
PAA739Hu02 Polyclonal Antibody to Cyclin Dependent Kinase 5 (CDK5) WB; IHC; ICC; IP.
Assay Kits SEA739Hu ELISA Kit for Cyclin Dependent Kinase 5 (CDK5) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin Dependent Kinase 5 (CDK5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin Dependent Kinase 5 (CDK5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin Dependent Kinase 5 (CDK5) Polyclonal Antibody Customized Service Offer
Assay Kits SEA739Mu ELISA Kit for Cyclin Dependent Kinase 5 (CDK5) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA739Ra01 Recombinant Cyclin Dependent Kinase 5 (CDK5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA739Ra01 Polyclonal Antibody to Cyclin Dependent Kinase 5 (CDK5) WB; IHC; ICC; IP.
MAA739Ra21 Monoclonal Antibody to Cyclin Dependent Kinase 5 (CDK5) WB; IHC; ICC; IP.
Assay Kits SEA739Ra ELISA Kit for Cyclin Dependent Kinase 5 (CDK5) Enzyme-linked immunosorbent assay for Antigen Detection.
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  30. "Cdk5 mediates vimentin Ser56 phosphorylation during GTP-induced secretion by neutrophils."J. Cell. Physiol. 227:739-750(2012) [PubMed] [Europe PMC] [Abstract]
  31. "Glutathione-S-transferase P1 is a critical regulator of Cdk5 kinase activity."J. Neurochem. 118:902-914(2011) [PubMed] [Europe PMC] [Abstract]
  32. "High NaCl-induced activation of CDK5 increases phosphorylation of the osmoprotective transcription factor TonEBP/OREBP at threonine 135, which contributes to its rapid nuclear localization."Mol. Biol. Cell 22:703-714(2011) [PubMed] [Europe PMC] [Abstract]
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