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Hypoxanthine Phosphoribosyltransferase 1 (HPRT1)

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HGPRT; HGPRTase; HPRT; Lesch-Nyhan Syndrome; Hypoxanthine-guanine phosphoribosyltransferase

Hypoxanthine Phosphoribosyltransferase 1 (HPRT1)
CCC A717
HGNC 5157
MGI 96217
PubMed 16355393
RGD 2826
UniProt P00492
Wiki HPRT
HPRT1 has a central role in the generation of purine nucleotides through the purine salvage pathway. HPRT1 catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate. The Lesch-Nyhan syndrome is particularly favorable for this purpose because no affected males reproduce, the diagnosis is unequivocal and cases come readily to attention, and particularly because heterozygosity can be demonstrated in females by the existence of 2 populations of cultured fibroblasts. There were few new mutations, contrary to the expected one-third. On the other hand, about one-half of heterozygous females were new mutations, as is predicted by theory.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA717Hu01 Recombinant Hypoxanthine Phosphoribosyltransferase 1 (HPRT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA717Hu01 Polyclonal Antibody to Hypoxanthine Phosphoribosyltransferase 1 (HPRT1) WB; IHC; ICC; IP.
MAA717Hu22 Monoclonal Antibody to Hypoxanthine Phosphoribosyltransferase 1 (HPRT1) WB; IHC; ICC; IP.
Assay Kits SEA717Hu ELISA Kit for Hypoxanthine Phosphoribosyltransferase 1 (HPRT1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA717Mu01 Recombinant Hypoxanthine Phosphoribosyltransferase 1 (HPRT1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA717Mu02 Recombinant Hypoxanthine Phosphoribosyltransferase 1 (HPRT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA717Mu01 Polyclonal Antibody to Hypoxanthine Phosphoribosyltransferase 1 (HPRT1) WB; IHC; ICC; IP.
PAA717Mu02 Polyclonal Antibody to Hypoxanthine Phosphoribosyltransferase 1 (HPRT1) WB; IHC; ICC; IP.
Assay Kits SEA717Mu ELISA Kit for Hypoxanthine Phosphoribosyltransferase 1 (HPRT1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hypoxanthine Phosphoribosyltransferase 1 (HPRT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hypoxanthine Phosphoribosyltransferase 1 (HPRT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hypoxanthine Phosphoribosyltransferase 1 (HPRT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hypoxanthine Phosphoribosyltransferase 1 (HPRT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hypoxanthine Phosphoribosyltransferase 1 (HPRT1) ELISA Kit Customized Service Offer
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