Heat Shock Protein 27 (Hsp27)
[Edit]HSPB1; HSP-B1; CMT2F; HSP28; Hsp25; Heat Shock 27kDa Protein 1; 28 kDa heat shock protein; Heat shock protein beta-1; Estrogen-regulated 24 kDa protein;
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Heat shock protein (HSP) 27 is one of the small HSPs. Like other small heat shock proteins, HSP27 is regulated at both the transcriptional and posttranslational levels . In response to stress, the expression level of HSP27 increases several-fold to confer cellular resistance to the adverse environmental change.
HSP27 is phosphorylated at Ser15, Ser78 and Ser82 by MAPKAP kinase 2 as a result of the activation of the p38 MAP kinase pathway . Phosphorylation of HSP27 causes a change in its tertiary structure, which shifts from large homotypic multimers to dimers and monomers . It has been shown that phosphorylation and increased concentration of HSP27 modulates actin polymerization and reorganization .
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA693Mu01 | Recombinant Heat Shock Protein 27 (Hsp27) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA693Mu02 | Recombinant Heat Shock Protein 27 (Hsp27) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA693Mu01 | Polyclonal Antibody to Heat Shock Protein 27 (Hsp27) | WB; IHC; ICC; IP. |
| PAA693Mu02 | Polyclonal Antibody to Heat Shock Protein 27 (Hsp27) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA693Mu | ELISA Kit for Heat Shock Protein 27 (Hsp27) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA693Ra01 | Recombinant Heat Shock Protein 27 (Hsp27) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA693Ra01 | Polyclonal Antibody to Heat Shock Protein 27 (Hsp27) | WB; IHC; ICC; IP. |
| MAA693Ra21 | Monoclonal Antibody to Heat Shock Protein 27 (Hsp27) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA693Ra | ELISA Kit for Heat Shock Protein 27 (Hsp27) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Oryctolagus cuniculus (Rabbit)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Heat Shock Protein 27 (Hsp27) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Heat Shock Protein 27 (Hsp27) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Heat Shock Protein 27 (Hsp27) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | SEA693Rb | ELISA Kit for Heat Shock Protein 27 (Hsp27) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Bos taurus; Bovine (Cattle)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA693Bo01 | Recombinant Heat Shock Protein 27 (Hsp27) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA693Bo01 | Polyclonal Antibody to Heat Shock Protein 27 (Hsp27) | WB; IHC; ICC; IP. |
| MAA693Bo21 | Monoclonal Antibody to Heat Shock Protein 27 (Hsp27) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA693Bo | ELISA Kit for Heat Shock Protein 27 (Hsp27) | Enzyme-linked immunosorbent assay for Antigen Detection. |
- "Sequence and organization of genes encoding the human 27 kDa heat shock protein."Nucleic Acids Res. 14:4127-4145(1986) [PubMed] [Europe PMC] [Abstract]
- "cDNA sequence of a human heat shock protein HSP27."Nucleic Acids Res. 18:6457-6457(1990) [PubMed] [Europe PMC] [Abstract]
- "Small heat shock protein 27 (HSP27) associates with tubulin/microtubules in HeLa cells."Biochem. Biophys. Res. Commun. 271:164-169(2000) [PubMed] [Europe PMC] [Abstract]
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- "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Identification of two related markers for common acute lymphoblastic leukemia as heat shock proteins."J. Clin. Invest. 85:200-207(1990) [PubMed] [Europe PMC] [Abstract]