≡

TGF Beta Inducible Early Response Gene 1 (TIEG1)

[Edit]

KLF10; EGRA; TIEG; Krueppel-Like Factor 10; TGFB Inducible Early Growth Response; EGR-alpha; Transforming growth factor-beta-inducible early growth response protein 1

TGF Beta Inducible Early Response Gene 1 (TIEG1)
CCC A688
HGNC 11810
MGI 1101353
PubMed 17729309
RGD 621652
UniProt Q13118
Wiki KLF10

Tachibana et al. characterized the expression and function in exocrine pancreatic epithelial cells of the TGF-beta-inducible early gene (TIEG), a Kruppel-like zinc finger transcription factor-encoding gene previously isolated from mesodermally derived osteoblastic cells by Subramaniam et al. Tachibana et al.  demonstrated that the gene is expressed in both acinar and ductular epithelial cell populations from the exocrine pancreas. In addition, they showed that the expression of TIEG is regulated by TGF-beta-1 (TGFB1) as an early response gene in pancreatic epithelial cell lines. Overexpression of TIEG in a TGF-beta-sensitive epithelial cell line was sufficient to induce apoptosis. Thus, Tachibana et al. concluded that TIEG plays a role in linking TGF-beta-mediated signaling cascades to the regulation of pancreatic epithelial cell growth.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA688Hu01 Recombinant TGF Beta Inducible Early Response Gene 1 (TIEG1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA688Hu01 Polyclonal Antibody to TGF Beta Inducible Early Response Gene 1 (TIEG1) WB; IHC; ICC; IP.
MAA688Hu22 Monoclonal Antibody to TGF Beta Inducible Early Response Gene 1 (TIEG1) WB; IHC; ICC; IP.
Assay Kits SEA688Hu ELISA Kit for TGF Beta Inducible Early Response Gene 1 (TIEG1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA688Mu01 Recombinant TGF Beta Inducible Early Response Gene 1 (TIEG1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA688Mu01 Polyclonal Antibody to TGF Beta Inducible Early Response Gene 1 (TIEG1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for TGF Beta Inducible Early Response Gene 1 (TIEG1) CLIA Kit Customized Service Offer
n/a ELISA Kit for TGF Beta Inducible Early Response Gene 1 (TIEG1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TGF Beta Inducible Early Response Gene 1 (TIEG1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TGF Beta Inducible Early Response Gene 1 (TIEG1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TGF Beta Inducible Early Response Gene 1 (TIEG1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TGF Beta Inducible Early Response Gene 1 (TIEG1) CLIA Kit Customized Service Offer
n/a ELISA Kit for TGF Beta Inducible Early Response Gene 1 (TIEG1) ELISA Kit Customized Service Offer
  1. "Characterization of an early growth response gene, which encodes a zinc finger transcription factor, potentially involved in cell cycle regulation."Mol. Endocrinol. 9:1610-1620(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of a novel TGF-beta-regulated gene encoding a putative zinc finger protein in human osteoblasts."Nucleic Acids Res. 23:4907-4912(1995) [PubMed] [Europe PMC] [Abstract]
  3. "TGFbeta-inducible early gene (TIEG) also codes for early growth response alpha (EGRalpha): evidence of multiple transcripts from alternate promoters."Genomics 51:408-416(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Shaking the family tree: Identification of novel and biologically active alternatively spliced isoforms across the KLF family of transcription factors."FASEB J. 27:432-436(2013) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Modulation of transforming growth factor beta (TGFbeta)/Smad transcriptional responses through targeted degradation of TGFbeta-inducible early gene-1 by human seven in absentia homologue."J. Biol. Chem. 277:30754-30759(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Identification and characterization of a consensus DNA binding element for the zinc finger transcription factor TIEG/EGRalpha."DNA Cell Biol. 22:187-199(2003) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Solution structure of the first and second ZF-C2H2 domains from human krueppel-like factor 10."Submitted (APR-2008) to the PDB data bank