Protein Kinase, AMP Activated Alpha 1 (AMPK Alpha 1)

[Edit]

PRKAa1; AMPK; AMPKa1; PKA; ACACA kinase; 5'-AMP-Activated Protein Kinase Catalytic Subunit Alpha-1; Acetyl-CoA carboxylase kinase; Hydroxymethylglutaryl-CoA reductase kinase

Protein Kinase, AMP Activated Alpha 1 (AMPK Alpha 1)

5'-AMP-activated protein kinase catalytic subunit alpha-1 is an enzyme belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells.

The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA679Hu01 Recombinant Protein Kinase, AMP Activated Alpha 1 (AMPK Alpha 1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA679Hu02 Recombinant Protein Kinase, AMP Activated Alpha 1 (AMPK Alpha 1) Positive Control; Immunogen; SDS-PAGE; WB.
APA679Hu01 Active Protein Kinase, AMP Activated Alpha 1 (AMPK Alpha 1) Cell culture; Activity Assays.
Antibodies PAA679Hu01 Polyclonal Antibody to Protein Kinase, AMP Activated Alpha 1 (AMPK Alpha 1) WB; IHC; ICC; IP.
MAA679Hu21 Monoclonal Antibody to Protein Kinase, AMP Activated Alpha 1 (AMPK Alpha 1) WB; IHC; ICC; IP.
Assay Kits SEA679Hu ELISA Kit for Protein Kinase, AMP Activated Alpha 1 (AMPK Alpha 1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA679Mu01 Recombinant Protein Kinase, AMP Activated Alpha 1 (AMPK Alpha 1) Positive Control; Immunogen; SDS-PAGE; WB.
APA679Mu01 Active Protein Kinase, AMP Activated Alpha 1 (AMPK Alpha 1) Cell culture; Activity Assays.
Antibodies PAA679Mu01 Polyclonal Antibody to Protein Kinase, AMP Activated Alpha 1 (AMPK Alpha 1) WB; IHC; ICC; IP.
Assay Kits SEA679Mu ELISA Kit for Protein Kinase, AMP Activated Alpha 1 (AMPK Alpha 1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Kinase, AMP Activated Alpha 1 (AMPK Alpha 1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Kinase, AMP Activated Alpha 1 (AMPK Alpha 1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Kinase, AMP Activated Alpha 1 (AMPK Alpha 1) Polyclonal Antibody Customized Service Offer
Assay Kits SEA679Ra ELISA Kit for Protein Kinase, AMP Activated Alpha 1 (AMPK Alpha 1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
  5. "Mammalian AMP-activated protein kinase subfamily."J. Biol. Chem. 271:611-614(1996) [PubMed] [Europe PMC] [Abstract]
  6. "Functional domains of the alpha1 catalytic subunit of the AMP-activated protein kinase."J. Biol. Chem. 273:35347-35354(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line."Biochem. Biophys. Res. Commun. 287:562-567(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Regulation of transcription by AMP-activated protein kinase: phosphorylation of p300 blocks its interaction with nuclear receptors."J. Biol. Chem. 276:38341-38344(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Role of AMP-activated protein kinase in mechanism of metformin action."J. Clin. Invest. 108:1167-1174(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Physiological modulation of CFTR activity by AMP-activated protein kinase in polarized T84 cells."Am. J. Physiol. 284:C1297-C1308(2003) [PubMed] [Europe PMC] [Abstract]
  11. "TSC2 mediates cellular energy response to control cell growth and survival."Cell 115:577-590(2003) [PubMed] [Europe PMC] [Abstract]
  12. "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1."EMBO J. 23:833-843(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase."Cell Metab. 2:9-19(2005) [PubMed] [Europe PMC] [Abstract]
  14. "The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases."J. Biol. Chem. 280:29060-29066(2005) [PubMed] [Europe PMC] [Abstract]
  15. "AMP-activated protein kinase induces a p53-dependent metabolic checkpoint."Mol. Cell 18:283-293(2005) [PubMed] [Europe PMC] [Abstract]
  16. "Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling."Proc. Natl. Acad. Sci. U.S.A. 103:15552-15557(2006) [PubMed] [Europe PMC] [Abstract]
  17. "Conserved alpha-helix acts as autoinhibitory sequence in AMP-activated protein kinase alpha subunits."J. Biol. Chem. 282:495-506(2007) [PubMed] [Europe PMC] [Abstract]
  18. "The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor."J. Biol. Chem. 282:30107-30119(2007) [PubMed] [Europe PMC] [Abstract]
  19. "Energy-dependent regulation of cell structure by AMP-activated protein kinase."Nature 447:1017-1020(2007) [PubMed] [Europe PMC] [Abstract]
  20. "AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5."Diabetes 57:860-867(2008) [PubMed] [Europe PMC] [Abstract]
  21. "Identification and characterization of a novel folliculin-interacting protein FNIP2."Gene 415:60-67(2008) [PubMed] [Europe PMC] [Abstract]
  22. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  23. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  24. "AMPK phosphorylation of raptor mediates a metabolic checkpoint."Mol. Cell 30:214-226(2008) [PubMed] [Europe PMC] [Abstract]
  25. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  26. "Interaction of folliculin (Birt-Hogg-Dube gene product) with a novel Fnip1-like (FnipL/Fnip2) protein."Oncogene 27:5339-5347(2008) [PubMed] [Europe PMC] [Abstract]
  27. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  28. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  29. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  30. "Cell-wide analysis of secretory granule dynamics in three dimensions in living pancreatic beta-cells: evidence against a role for AMPK-dependent phosphorylation of KLC1 at Ser517/Ser520 in glucose-stimulated insulin granule movement."Biochem. Soc. Trans. 38:205-208(2010) [PubMed] [Europe PMC] [Abstract]
  31. "ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS."Proc. Natl. Acad. Sci. U.S.A. 107:4153-4158(2010) [PubMed] [Europe PMC] [Abstract]
  32. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  33. "Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop."Autophagy 7:696-706(2011) [PubMed] [Europe PMC] [Abstract]
  34. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  35. "Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy."Science 331:456-461(2011) [PubMed] [Europe PMC] [Abstract]
  36. "AMPK is a direct adenylate charge-regulated protein kinase."Science 332:1433-1435(2011) [PubMed] [Europe PMC] [Abstract]
  37. "AMP-activated protein kinase in metabolic control and insulin signaling."Circ. Res. 100:328-341(2007) [PubMed] [Europe PMC] [Abstract]
  38. "AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy."Nat. Rev. Mol. Cell Biol. 8:774-785(2007) [PubMed] [Europe PMC] [Abstract]
  39. "N-Myristoylation is essential for protein phosphatases PPM1A and PPM1B to dephosphorylate their physiological substrates in cells."Biochem. J. 449:741-749(2013) [PubMed] [Europe PMC] [Abstract]
  40. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  41. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]