Adiponectin (ADPN)

[Edit]

GBP28; ApM1; AdipoQ; Acrp30; ACDC; APM1; C1Q And Collagen Domain Containing; Adipocyte Complement-Related Protein Of 30 KDa; Adipose Most Abundant Gene Transcript 1

Adiponectin (ADPN)

Adiponectin, alternatively named Adipocyte Complement-Related Protein of 30 kDa, shares structural similarity with complement factor C1q and is a member of the family of defense collagens. It is secreted exclusively by differentiated adipocytes and circulates at high concentrations. Adiponectin has a modular structure comprising an N-terminal collagenous domain with multiple collagen triple helix repeats, followed by a C-terminal C1q-like globular domain. The globular domain has similar folding topology with tumor necrosis factor-α and assembles into homotrimers. Higher order oligomeric adiponectins are also formed via interactions between the collagenous stalk. A truncated form of Adiponectin containing only the globular domain can be generated by proteolytic cleavage.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA605Hu01 Recombinant Adiponectin (ADPN) Positive Control; Immunogen; SDS-PAGE; WB.
CPA605Hu21 OVA Conjugated Adiponectin (ADPN) Immunogen; SDS-PAGE; WB.
Antibodies PAA605Hu01 Polyclonal Antibody to Adiponectin (ADPN) WB; IHC; ICC/IF
MAA605Hu22 Monoclonal Antibody to Adiponectin (ADPN) WB; IHC
LAA605Hu71 Biotin-Linked Polyclonal Antibody to Adiponectin (ADPN) WB
LAA605Hu81 FITC-Linked Polyclonal Antibody to Adiponectin (ADPN) WB; IHC; ICC; IF.
PAA605Hu08 Polyclonal Antibody to Adiponectin (ADPN) WB; IHC; ICC; IP.
MAA605Hu21 Monoclonal Antibody to Adiponectin (ADPN) WB; IHC
MAA605Hu23 Monoclonal Antibody to Adiponectin (ADPN) WB; IHC
MAA605Hu24 Monoclonal Antibody to Adiponectin (ADPN) WB; IHC
MAA605Hu25 Monoclonal Antibody to Adiponectin (ADPN) WB; IHC
MAA605Hu26 Monoclonal Antibody to Adiponectin (ADPN) ICC/IF
Assay Kits SEA605Hu ELISA Kit for Adiponectin (ADPN) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA605Hu CLIA Kit for Adiponectin (ADPN) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA605Mu01 Recombinant Adiponectin (ADPN) Positive Control; Immunogen; SDS-PAGE; WB.
RPA605Mu02 Recombinant Adiponectin (ADPN) Positive Control; Immunogen; SDS-PAGE; WB.
RPA605Mu03 Recombinant Adiponectin (ADPN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA605Mu01 Polyclonal Antibody to Adiponectin (ADPN) WB
PAA605Mu02 Polyclonal Antibody to Adiponectin (ADPN) WB; IHC
Assay Kits SEA605Mu ELISA Kit for Adiponectin (ADPN) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA605Mu CLIA Kit for Adiponectin (ADPN) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA605Ra01 Recombinant Adiponectin (ADPN) Positive Control; Immunogen; SDS-PAGE; WB.
RPA605Ra02 Recombinant Adiponectin (ADPN) Positive Control; Immunogen; SDS-PAGE; WB.
EPA605Ra61 Eukaryotic Adiponectin (ADPN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA605Ra01 Polyclonal Antibody to Adiponectin (ADPN) WB; IHC
LAA605Ra71 Biotin-Linked Polyclonal Antibody to Adiponectin (ADPN) IHC
MAA605Ra21 Monoclonal Antibody to Adiponectin (ADPN) IHC
PAA605Ra02 Polyclonal Antibody to Adiponectin (ADPN) WB
MAA605Ra22 Monoclonal Antibody to Adiponectin (ADPN) IHC
MAA605Ra23 Monoclonal Antibody to Adiponectin (ADPN) IHC
MAA605Ra24 Monoclonal Antibody to Adiponectin (ADPN) IHC
MAA605Ra25 Monoclonal Antibody to Adiponectin (ADPN) ICC/IF
Assay Kits SEA605Ra ELISA Kit for Adiponectin (ADPN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA605Rb01 Recombinant Adiponectin (ADPN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA605Rb51 Polyclonal Antibody to Adiponectin (ADPN) WB; IHC; ICC; IP.
MAA605Rb21 Monoclonal Antibody to Adiponectin (ADPN) WB; IHC; ICC; IP.
Assay Kits SEA605Rb ELISA Kit for Adiponectin (ADPN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA605Ca01 Recombinant Adiponectin (ADPN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA605Ca01 Polyclonal Antibody to Adiponectin (ADPN) WB
MAA605Ca21 Monoclonal Antibody to Adiponectin (ADPN) WB; IHC; ICC; IP.
Assay Kits SEA605Ca ELISA Kit for Adiponectin (ADPN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA605Po01 Recombinant Adiponectin (ADPN) Positive Control; Immunogen; SDS-PAGE; WB.
EPA605Po61 Eukaryotic Adiponectin (ADPN) Positive Control; Immunogen; SDS-PAGE; WB.
APA605Po61 Active Adiponectin (ADPN) Cell culture; Activity Assays.
Antibodies PAA605Po01 Polyclonal Antibody to Adiponectin (ADPN) WB; IHC
LAA605Po81 FITC-Linked Polyclonal Antibody to Adiponectin (ADPN) WB; IHC; ICC; IF.
LAA605Po71 Biotin-Linked Polyclonal Antibody to Adiponectin (ADPN) WB; IHC; ICC.
MAA605Po21 Monoclonal Antibody to Adiponectin (ADPN) WB; IHC
MAA605Po22 Monoclonal Antibody to Adiponectin (ADPN) IHC; ICC/IF
MAA605Po26 Monoclonal Antibody to Adiponectin (ADPN) WB
Assay Kits SEA605Po ELISA Kit for Adiponectin (ADPN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA605Bo01 Recombinant Adiponectin (ADPN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA605Bo01 Polyclonal Antibody to Adiponectin (ADPN) WB
MAA605Bo21 Monoclonal Antibody to Adiponectin (ADPN) WB; IHC; ICC; IP.
Assay Kits SEA605Bo ELISA Kit for Adiponectin (ADPN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA605Ga01 Recombinant Adiponectin (ADPN) Positive Control; Immunogen; SDS-PAGE; WB.
APA605Ga01 Active Adiponectin (ADPN) Cell culture; Activity Assays.
Antibodies PAA605Ga01 Polyclonal Antibody to Adiponectin (ADPN) WB
MAA605Ga21 Monoclonal Antibody to Adiponectin (ADPN) WB; IHC; ICC; IP.
Assay Kits SEA605Ga ELISA Kit for Adiponectin (ADPN) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA605Ga CLIA Kit for Adiponectin (ADPN) Chemiluminescent immunoassay for Antigen Detection.
  1. "cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1)."Biochem. Biophys. Res. Commun. 221:286-289(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Organization of the gene for gelatin-binding protein (GBP28)."Gene 229:67-73(1999) [PubMed] [Europe PMC] [Abstract]
  3. "The human apM-1, an adipocyte-specific gene linked to the family of TNF's and to genes expressed in activated T cells, is mapped to chromosome 1q21.3-q23, a susceptibility locus identified for familial combined hyperlipidemia (FCH)."Biochem. Biophys. Res. Commun. 260:416-425(1999) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma."J. Biochem. 120:803-812(1996) [PubMed] [Europe PMC] [Abstract]
  7. "Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages."Blood 96:1723-1732(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway."Circulation 102:1296-1301(2000) [PubMed] [Europe PMC] [Abstract]
  9. "The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity." Nat. Med. 7:941-946(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin."J. Biol. Chem. 278:40352-40363(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Adiponectin multimerization is dependent on conserved lysines in the collagenous domain: evidence for regulation of multimerization by alterations in posttranslational modifications."Mol. Endocrinol. 20:1673-1687(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Sialic acid modification of adiponectin is not required for multimerization or secretion but determines half-life in circulation."Mol. Endocrinol. 24:229-239(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Resveratrol-induced changes of the human adipocyte secretion profile."J. Proteome Res. 11:4733-4743(2012) [PubMed] [Europe PMC] [Abstract]
  14. "Crystal structure of a single-chain trimer of human adiponectin globular domain."FEBS Lett. 586:912-917(2012) [PubMed] [Europe PMC] [Abstract]
  15. "Genomic structure and mutations in adipose-specific gene, adiponectin."Int. J. Obes. Relat. Metab. Disord. 24:861-868(2000) [PubMed] [Europe PMC] [Abstract]
  16. "Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population." Diabetes 51:536-540(2002) [PubMed] [Europe PMC] [Abstract]
  17. Erratum Diabetes 51:1294-1294(2002)
  18. "Association of adiponectin mutation with type 2 diabetes: a candidate gene for the insulin resistance syndrome."Diabetes 51:2325-2328(2002) [PubMed] [Europe PMC] [Abstract]
  19. "Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians."Hum. Mol. Genet. 11:2607-2614(2002) [PubMed] [Europe PMC] [Abstract]