Proliferating Cell Nuclear Antigen (PCNA)

Proliferating Cell Nuclear Antigen a protein that acts as a processivity factor for DNA polymerase delta in eukaryotic cells. It achieves this processivity by encircling the DNA, thus creating a topological link to the genome. It is an example of a DNA clamp. The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA591Mi01 Recombinant Proliferating Cell Nuclear Antigen (PCNA) Positive Control; Immunogen; SDS-PAGE; WB.
RPA591Hu01 Recombinant Proliferating Cell Nuclear Antigen (PCNA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA591Mi01 Polyclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB,IHC
CAA591Hu22 Anti-Proliferating Cell Nuclear Antigen (PCNA) Monoclonal Antibody Loading Control of WB.
CAA591Hu01 Anti-Proliferating Cell Nuclear Antigen (PCNA) Polyclonal Antibody Loading Control of WB.
MAA591Hu21 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
PAA591Hu01 Polyclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
MAA591Mi21 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
CAA591Mi22 Anti-Proliferating Cell Nuclear Antigen (PCNA) Monoclonal Antibody Loading Control of WB
MAA591Mi22 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
MAA591Mi23 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
MAA591Hu22 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
MAA591Hu23 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
MAA591Hu25 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
MAA591Hu24 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
MAA591Mi24 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
Assay Kits SEA591Mi ELISA Kit for Proliferating Cell Nuclear Antigen (PCNA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA591Mi01 Recombinant Proliferating Cell Nuclear Antigen (PCNA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA591Mi01 Polyclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB,IHC
MAA591Mi21 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
CAA591Mi22 Anti-Proliferating Cell Nuclear Antigen (PCNA) Monoclonal Antibody Loading Control of WB
MAA591Mi22 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
MAA591Mi23 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
MAA591Mi24 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
Assay Kits SEA591Mi ELISA Kit for Proliferating Cell Nuclear Antigen (PCNA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA591Mi01 Recombinant Proliferating Cell Nuclear Antigen (PCNA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA591Mi01 Polyclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB,IHC
MAA591Mi21 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
CAA591Mi22 Anti-Proliferating Cell Nuclear Antigen (PCNA) Monoclonal Antibody Loading Control of WB
MAA591Mi22 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
MAA591Mi23 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
MAA591Mi24 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
Assay Kits SEA591Mi ELISA Kit for Proliferating Cell Nuclear Antigen (PCNA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Cavia (Guinea pig )

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proliferating Cell Nuclear Antigen (PCNA) Recombinant Protein Customized Service Offer
Antibodies MAA591Mi24 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Proliferating Cell Nuclear Antigen (PCNA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proliferating Cell Nuclear Antigen (PCNA) ELISA Kit Customized Service Offer

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proliferating Cell Nuclear Antigen (PCNA) Recombinant Protein Customized Service Offer
Antibodies PAA591Mi01 Polyclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB,IHC
MAA591Mi22 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Proliferating Cell Nuclear Antigen (PCNA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proliferating Cell Nuclear Antigen (PCNA) ELISA Kit Customized Service Offer

Organism species: Rhesus monkey (Simian)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proliferating Cell Nuclear Antigen (PCNA) Recombinant Protein Customized Service Offer
Antibodies PAA591Mi01 Polyclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB,IHC
MAA591Mi24 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Proliferating Cell Nuclear Antigen (PCNA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proliferating Cell Nuclear Antigen (PCNA) ELISA Kit Customized Service Offer

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proliferating Cell Nuclear Antigen (PCNA) Recombinant Protein Customized Service Offer
Antibodies PAA591Mi01 Polyclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB,IHC
MAA591Mi21 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
CAA591Mi22 Anti-Proliferating Cell Nuclear Antigen (PCNA) Monoclonal Antibody Loading Control of WB
MAA591Mi22 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
MAA591Mi24 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Proliferating Cell Nuclear Antigen (PCNA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proliferating Cell Nuclear Antigen (PCNA) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proliferating Cell Nuclear Antigen (PCNA) Recombinant Protein Customized Service Offer
Antibodies PAA591Mi01 Polyclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB,IHC
MAA591Mi21 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
MAA591Mi22 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
MAA591Mi23 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
MAA591Mi24 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Proliferating Cell Nuclear Antigen (PCNA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proliferating Cell Nuclear Antigen (PCNA) ELISA Kit Customized Service Offer

Organism species: Capra hircus; Caprine (Goat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proliferating Cell Nuclear Antigen (PCNA) Recombinant Protein Customized Service Offer
Antibodies MAA591Mi24 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Proliferating Cell Nuclear Antigen (PCNA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proliferating Cell Nuclear Antigen (PCNA) ELISA Kit Customized Service Offer

Organism species: Ovis aries; Ovine (Sheep)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proliferating Cell Nuclear Antigen (PCNA) Recombinant Protein Customized Service Offer
Antibodies MAA591Mi24 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Proliferating Cell Nuclear Antigen (PCNA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proliferating Cell Nuclear Antigen (PCNA) ELISA Kit Customized Service Offer

Organism species: Equus caballus; Equine (Horse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proliferating Cell Nuclear Antigen (PCNA) Recombinant Protein Customized Service Offer
Antibodies MAA591Mi24 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Proliferating Cell Nuclear Antigen (PCNA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proliferating Cell Nuclear Antigen (PCNA) ELISA Kit Customized Service Offer

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proliferating Cell Nuclear Antigen (PCNA) Recombinant Protein Customized Service Offer
Antibodies MAA591Mi24 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Proliferating Cell Nuclear Antigen (PCNA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proliferating Cell Nuclear Antigen (PCNA) ELISA Kit Customized Service Offer
  1. "Cloning and sequence of the human nuclear protein cyclin: homology with DNA-binding proteins."Proc. Natl. Acad. Sci. U.S.A. 84:1575-1579(1987) [PubMed] [Europe PMC] [Abstract]
  2. "Structure of the human gene for the proliferating cell nuclear antigen."J. Biol. Chem. 264:7466-7472(1989) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The cell-cycle regulated proliferating cell nuclear antigen is required for SV40 DNA replication in vitro."Nature 326:471-475(1987) [PubMed] [Europe PMC] [Abstract]