Matrix Metalloproteinase 9 (MMP9)
[Edit]GELB; Gelatinase B; CLG4B; CLG4-B; 92 KDa Gelatinase; 92kDa Type IV Collagenase
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MMP-9 (also known as gelatinase B) is secreted as a 92 kDa zymogen. Cleavage of pro-MMP-9 at or near residue 87 results in the active enzyme with a mass of approximately 82 kDa. MMP-9 has three fibronectin type II domains, a hemopexin-like domain and a proline-rich type V collagen-homologous domain.
Pro-MMP-9 can be activated by MMP-3 or by certain bacterial proteinases. MMP-9 is inhibited byα2-macroglobulin or by TIMP-1, which binds to pro-MMP-9 as well as to active MMP-9.Pro-MMP-9 is secreted by monocytes, macrophages, neutrophils, keratinocytes, fibroblasts, osteoclasts, chondrocytes, skeletal muscle satellite cells, endothelial cells, and various tumor cells. Pro-MMP-9 expression is upregulated by TGF-β1, IL-1β, TGF-α, PDGF-AB,
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA553Mu01 | Recombinant Matrix Metalloproteinase 9 (MMP9) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA553Mu02 | Recombinant Matrix Metalloproteinase 9 (MMP9) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| EPA553Mu51 | Eukaryotic Matrix Metalloproteinase 9 (MMP9) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APA553Mu01 | Active Matrix Metalloproteinase 9 (MMP9) | Cell culture; Activity Assays. | |
| EPA553Mu61 | Eukaryotic Matrix Metalloproteinase 9 (MMP9) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APA553Mu61 | Active Matrix Metalloproteinase 9 (MMP9) | Cell culture; Activity Assays. | |
| APA553Mu62 | Active Matrix Metalloproteinase 9 (MMP9) | Cell culture; Activity Assays. | |
| EPA553Mu62 | Eukaryotic Matrix Metalloproteinase 9 (MMP9) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA553Mu01 | Polyclonal Antibody to Matrix Metalloproteinase 9 (MMP9) | WB; ICC/IF |
| LAA553Mu71 | Biotin-Linked Polyclonal Antibody to Matrix Metalloproteinase 9 (MMP9) | WB; IHC; ICC. | |
| PAA553Mu07 | Polyclonal Antibody to Matrix Metalloproteinase 9 (MMP9) | WB; IHC; ICC; IP. | |
| PAA553Mu02 | Polyclonal Antibody to Matrix Metalloproteinase 9 (MMP9) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA553Mu | ELISA Kit for Matrix Metalloproteinase 9 (MMP9) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCA553Mu | CLIA Kit for Matrix Metalloproteinase 9 (MMP9) | Chemiluminescent immunoassay for Antigen Detection. | |
| AEA553Mu | ELISA Kit for Anti-Matrix Metalloproteinase 9 Antibody (Anti-MMP9) | Enzyme-linked immunosorbent assay for Antibody Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA553Ra01 | Recombinant Matrix Metalloproteinase 9 (MMP9) | Positive Control; Immunogen; SDS-PAGE; WB. |
| EPA553Ra51 | Eukaryotic Matrix Metalloproteinase 9 (MMP9) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA553Ra01 | Polyclonal Antibody to Matrix Metalloproteinase 9 (MMP9) | WB,IHC |
| LAA553Ra71 | Biotin-Linked Polyclonal Antibody to Matrix Metalloproteinase 9 (MMP9) | WB; IHC; ICC. | |
| LAA553Ra81 | FITC-Linked Polyclonal Antibody to Matrix Metalloproteinase 9 (MMP9) | WB; IHC; ICC; IF. | |
| MAA553Ra21 | Monoclonal Antibody to Matrix Metalloproteinase 9 (MMP9) | WB; IHC; ICC; IP. | |
| PAA553Ra07 | Polyclonal Antibody to Matrix Metalloproteinase 9 (MMP9) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA553Ra | ELISA Kit for Matrix Metalloproteinase 9 (MMP9) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Oryctolagus cuniculus (Rabbit)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA553Rb01 | Recombinant Matrix Metalloproteinase 9 (MMP9) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAA553Rb21 | Monoclonal Antibody to Matrix Metalloproteinase 9 (MMP9) | WB; IHC; ICC; IP. |
| PAA553Rb51 | Polyclonal Antibody to Matrix Metalloproteinase 9 (MMP9) | WB; IHC; ICC; IP. | |
| PAA553Rb01 | Polyclonal Antibody to Matrix Metalloproteinase 9 (MMP9) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA553Rb | ELISA Kit for Matrix Metalloproteinase 9 (MMP9) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rhesus monkey (Simian)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Matrix Metalloproteinase 9 (MMP9) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Matrix Metalloproteinase 9 (MMP9) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Matrix Metalloproteinase 9 (MMP9) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | SEA553Si | ELISA Kit for Matrix Metalloproteinase 9 (MMP9) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Canis familiaris; Canine (Dog)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA553Ca01 | Recombinant Matrix Metalloproteinase 9 (MMP9) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA553Ca01 | Polyclonal Antibody to Matrix Metalloproteinase 9 (MMP9) | WB; IHC; ICC; IP. |
| MAA553Ca21 | Monoclonal Antibody to Matrix Metalloproteinase 9 (MMP9) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA553Ca | ELISA Kit for Matrix Metalloproteinase 9 (MMP9) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Sus scrofa; Porcine (Pig)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA553Po01 | Recombinant Matrix Metalloproteinase 9 (MMP9) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APA553Po01 | Active Matrix Metalloproteinase 9 (MMP9) | Cell culture; Activity Assays. | |
| Antibodies | PAA553Po01 | Polyclonal Antibody to Matrix Metalloproteinase 9 (MMP9) | WB; IHC; ICC; IP. |
| MAA553Po21 | Monoclonal Antibody to Matrix Metalloproteinase 9 (MMP9) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA553Po | ELISA Kit for Matrix Metalloproteinase 9 (MMP9) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Bos taurus; Bovine (Cattle)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA553Bo01 | Recombinant Matrix Metalloproteinase 9 (MMP9) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA553Bo01 | Polyclonal Antibody to Matrix Metalloproteinase 9 (MMP9) | WB; IHC; ICC; IP. |
| MAA553Bo21 | Monoclonal Antibody to Matrix Metalloproteinase 9 (MMP9) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA553Bo | ELISA Kit for Matrix Metalloproteinase 9 (MMP9) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Equus caballus; Equine (Horse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA553Eq01 | Recombinant Matrix Metalloproteinase 9 (MMP9) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA553Eq01 | Polyclonal Antibody to Matrix Metalloproteinase 9 (MMP9) | WB; IHC; ICC; IP. |
| MAA553Eq21 | Monoclonal Antibody to Matrix Metalloproteinase 9 (MMP9) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA553Eq | ELISA Kit for Matrix Metalloproteinase 9 (MMP9) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| HEA553Eq | High Sensitive ELISA Kit for Matrix Metalloproteinase 9 (MMP9) | Enzyme-linked immunosorbent assay for Antigen Detection. |
- "SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages."J. Biol. Chem. 264:17213-17221(1989) [PubMed] [Europe PMC] [Abstract]
- "Complete structure of the human gene for 92-kDa type IV collagenase. Divergent regulation of expression for the 92- and 72-kilodalton enzyme genes in HT-1080 cells."J. Biol. Chem. 266:16485-16490(1991) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells."Oncogene 8:395-405(1993) [PubMed] [Europe PMC] [Abstract]
- "Human neutrophil gelatinase: a marker for circulating blood neutrophils. Purification and quantitation by enzyme linked immunosorbent assay."Eur. J. Haematol. 49:180-191(1992) [PubMed] [Europe PMC] [Abstract]
- "The cytokine-protease connection: identification of a 96-kD THP-1 gelatinase and regulation by interleukin-1 and cytokine inducers."Cytokine 3:231-239(1991) [PubMed] [Europe PMC] [Abstract]
- "Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase 9."J. Biol. Chem. 267:3581-3584(1992) [PubMed] [Europe PMC] [Abstract]
- "Matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) from HT 1080 human fibrosarcoma cells. Purification and activation of the precursor and enzymic properties."J. Biol. Chem. 267:21712-21719(1992) [PubMed] [Europe PMC] [Abstract]
- "Proteolytic and non-proteolytic activation of human neutrophil progelatinase B."Biochim. Biophys. Acta 1251:99-108(1995) [PubMed] [Europe PMC] [Abstract]
- "Purification and identification of 91-kDa neutrophil gelatinase. Release by the activating peptide interleukin-8."Eur. J. Biochem. 198:391-398(1991) [PubMed] [Europe PMC] [Abstract]
- "Cytokine-mediated regulation of human leukocyte gelatinases and role in arthritis."Lymphokine Cytokine Res. 10:317-324(1991) [PubMed] [Europe PMC] [Abstract]
- "Latent collagenase and gelatinase from human neutrophils and their activation."Matrix Suppl. 1:245-255(1992) [PubMed] [Europe PMC] [Abstract]
- "Purification and characterization of human 92-kDa type IV collagenase (gelatinase B)."Exp. Mol. Med. 28:161-165(1996)
- "Characterization of the monomeric and dimeric forms of latent and active matrix metalloproteinase-9. Differential rates for activation by stromelysin 1."J. Biol. Chem. 275:2661-2668(2000) [PubMed] [Europe PMC] [Abstract]
- "Salivary histatin 5 is an inhibitor of both host and bacterial enzymes implicated in periodontal disease."Infect. Immun. 69:1402-1408(2001) [PubMed] [Europe PMC] [Abstract]
- "Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases."Oncogene 22:4617-4626(2003) [PubMed] [Europe PMC] [Abstract]
- "Extracellular matrix protein 1 inhibits the activity of matrix metalloproteinase 9 through high-affinity protein/protein interactions."Exp. Dermatol. 15:300-307(2006) [PubMed] [Europe PMC] [Abstract]
- "A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation."Am. J. Hum. Genet. 82:1122-1129(2008) [PubMed] [Europe PMC] [Abstract]
- "Mutations in MMP9 and MMP13 determine the mode of inheritance and the clinical spectrum of metaphyseal anadysplasia."Am. J. Hum. Genet. 85:168-178(2009) [PubMed] [Europe PMC] [Abstract]
- "The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice."EMBO Rep. 10:1355-1362(2009) [PubMed] [Europe PMC] [Abstract]
- "Structure of the C-terminally truncated human ProMMP9, a gelatin-binding matrix metalloproteinase."Acta Crystallogr. D 58:1182-1192(2002) [PubMed] [Europe PMC] [Abstract]
- "Crystal structure of human MMP9 in complex with a reverse hydroxamate inhibitor."J. Mol. Biol. 319:173-181(2002) [PubMed] [Europe PMC] [Abstract]
- "Structural basis of the adaptive molecular recognition by MMP9."J. Mol. Biol. 320:1065-1079(2002) [PubMed] [Europe PMC] [Abstract]
- "Theoretical model of human type IV collagenase precursor."Submitted (APR-2002) to the PDB data bank
- "Genetic variation at the matrix metalloproteinase-9 locus on chromosome 20q12.2-13.1."Hum. Genet. 105:418-423(1999) [PubMed] [Europe PMC] [Abstract]