Plasminogen Activator Inhibitor 2 (PAI2)

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SERPINB2; PLANH2; Serpin Peptidase Inhibitor Clade B Member 2; Monocyte Arg-serpin; Placental plasminogen activator inhibitor; Serpin B2; Urokinase inhibitor

Plasminogen Activator Inhibitor 2 (PAI2)

Plasminogen activator inhibitor-2 (placental PAI) is a coagulation factor that inactivates tPA and urokinase. It is present in most cells, especially monocytes/macrophages. PAI-2 exists in two forms, a 60-kDa extracellular glycosylated form and a 43-kDa intracellular form.

It is present only at detectable quantities in blood during pregnancy, as it is produced by the placenta, and may explain partially the increased rate of thrombosis during pregnancy. The majority of expressed PAI-2 remains unsecreted due to the presence of an inefficient internal signal peptide.the intron-exon arrangement of PAI2 is identical to that of chicken ovalbumin and Y genes and distinct from that of other members of the serpin superfamily.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA531Hu01 Recombinant Plasminogen Activator Inhibitor 2 (PAI2) Positive Control; Immunogen; SDS-PAGE; WB.
APA531Hu01 Active Plasminogen Activator Inhibitor 2 (PAI2) Cell culture; Activity Assays.
EPA531Hu61 Eukaryotic Plasminogen Activator Inhibitor 2 (PAI2) Positive Control; Immunogen; SDS-PAGE; WB.
APA531Hu61 Active Plasminogen Activator Inhibitor 2 (PAI2) Cell culture; Activity Assays.
Antibodies PAA531Hu01 Polyclonal Antibody to Plasminogen Activator Inhibitor 2 (PAI2) WB; IHC; ICC; IP.
MAA531Hu22 Monoclonal Antibody to Plasminogen Activator Inhibitor 2 (PAI2) WB; IHC; ICC; IP.
Assay Kits SEA531Hu ELISA Kit for Plasminogen Activator Inhibitor 2 (PAI2) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA531Hu CLIA Kit for Plasminogen Activator Inhibitor 2 (PAI2) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA531Mu01 Recombinant Plasminogen Activator Inhibitor 2 (PAI2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA531Mu02 Recombinant Plasminogen Activator Inhibitor 2 (PAI2) Positive Control; Immunogen; SDS-PAGE; WB.
EPA531Mu61 Eukaryotic Plasminogen Activator Inhibitor 2 (PAI2) Positive Control; Immunogen; SDS-PAGE; WB.
APA531Mu61 Active Plasminogen Activator Inhibitor 2 (PAI2) Cell culture; Activity Assays.
Antibodies PAA531Mu01 Polyclonal Antibody to Plasminogen Activator Inhibitor 2 (PAI2) WB; IHC; ICC; IP.
PAA531Mu02 Polyclonal Antibody to Plasminogen Activator Inhibitor 2 (PAI2) WB; IHC; ICC; IP.
Assay Kits SEA531Mu ELISA Kit for Plasminogen Activator Inhibitor 2 (PAI2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA531Ra01 Recombinant Plasminogen Activator Inhibitor 2 (PAI2) Positive Control; Immunogen; SDS-PAGE; WB.
EPA531Ra61 Eukaryotic Plasminogen Activator Inhibitor 2 (PAI2) Positive Control; Immunogen; SDS-PAGE; WB.
APA531Ra61 Active Plasminogen Activator Inhibitor 2 (PAI2) Cell culture; Activity Assays.
Antibodies PAA531Ra01 Polyclonal Antibody to Plasminogen Activator Inhibitor 2 (PAI2) WB; IHC; ICC; IP.
MAA531Ra21 Monoclonal Antibody to Plasminogen Activator Inhibitor 2 (PAI2) WB; IHC; ICC; IP.
MAA531Ra22 Monoclonal Antibody to Plasminogen Activator Inhibitor 2 (PAI2) WB; IHC; ICC; IP.
MAA531Ra23 Monoclonal Antibody to Plasminogen Activator Inhibitor 2 (PAI2) WB; IHC; ICC; IP.
MAA531Ra24 Monoclonal Antibody to Plasminogen Activator Inhibitor 2 (PAI2) WB; IHC; ICC; IP.
MAA531Ra25 Monoclonal Antibody to Plasminogen Activator Inhibitor 2 (PAI2) WB; IHC; ICC; IP.
Assay Kits SEA531Ra ELISA Kit for Plasminogen Activator Inhibitor 2 (PAI2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA531Rb01 Recombinant Plasminogen Activator Inhibitor 2 (PAI2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA531Rb51 Polyclonal Antibody to Plasminogen Activator Inhibitor 2 (PAI2) WB; IHC; ICC; IP.
MAA531Rb21 Monoclonal Antibody to Plasminogen Activator Inhibitor 2 (PAI2) WB; IHC; ICC; IP.
Assay Kits SEA531Rb ELISA Kit for Plasminogen Activator Inhibitor 2 (PAI2) Enzyme-linked immunosorbent assay for Antigen Detection.
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  2. "Plasminogen activator inhibitor 2: regulation of gene transcription during phorbol ester-mediated differentiation of U-937 human histiocytic lymphoma cells."Mol. Cell. Biol. 7:4564-4567(1987) [PubMed] [Europe PMC] [Abstract]
  3. "Human monocyte Arg-Serpin cDNA. Sequence, chromosomal assignment, and homology to plasminogen activator-inhibitor."J. Exp. Med. 166:77-94(1987) [PubMed] [Europe PMC] [Abstract]
  4. "Cloning and expression of a cDNA coding for a human monocyte-derived plasminogen activator inhibitor."Proc. Natl. Acad. Sci. U.S.A. 85:985-989(1988) [PubMed] [Europe PMC] [Abstract]
  5. "Structure of the gene for human plasminogen activator inhibitor-2. The nearest mammalian homologue of chicken ovalbumin."J. Biol. Chem. 264:5495-5502(1989) [PubMed] [Europe PMC] [Abstract]
  6. "Chromosomal organization and localization of the human urokinase inhibitor gene: perfect structural conservation with ovalbumin."Genomics 6:159-167(1990) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes."Electrophoresis 13:960-969(1992) [PubMed] [Europe PMC] [Abstract]
  9. "Interaction of plasminogen activator inhibitor-2 and proteasome subunit, beta type 1."Acta Biochim. Biophys. Sin. 36:42-46(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "The crystal structure of plasminogen activator inhibitor 2 at 2.0-A resolution: implications for serpin function."Structure 7:43-54(1999) [PubMed] [Europe PMC] [Abstract]
  12. "Characterization of single-nucleotide polymorphisms in coding regions of human genes."Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
  13. ErratumNat. Genet. 23:373-373(1999)