-90524.jpg)
Coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces.
There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA524Hu01 | Recombinant Tissue Factor (TF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA524Hu01 | Polyclonal Antibody to Tissue Factor (TF) | WB; IHC; ICC; IP. |
| LAA524Hu71 | Biotin-Linked Polyclonal Antibody to Tissue Factor (TF) | WB; IHC; ICC. | |
| LAA524Hu81 | FITC-Linked Polyclonal Antibody to Tissue Factor (TF) | WB; IHC; ICC; IF. | |
| MAA524Hu21 | Monoclonal Antibody to Tissue Factor (TF) | WB; IHC; ICC; IP. | |
| MAA524Hu22 | Monoclonal Antibody to Tissue Factor (TF) | WB; IHC; ICC; IP. | |
| MAA524Hu23 | Monoclonal Antibody to Tissue Factor (TF) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA524Hu | ELISA Kit for Tissue Factor (TF) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCA524Hu | CLIA Kit for Tissue Factor (TF) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA524Mu01 | Recombinant Tissue Factor (TF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA524Mu02 | Recombinant Tissue Factor (TF) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA524Mu01 | Polyclonal Antibody to Tissue Factor (TF) | WB; IHC; ICC; IP. |
| LAA524Mu71 | Biotin-Linked Polyclonal Antibody to Tissue Factor (TF) | WB; IHC; ICC. | |
| LAA524Mu81 | FITC-Linked Polyclonal Antibody to Tissue Factor (TF) | WB; IHC; ICC; IF. | |
| PAA524Mu02 | Polyclonal Antibody to Tissue Factor (TF) | WB; IHC; ICC; IP. | |
| MAA524Mu21 | Monoclonal Antibody to Tissue Factor (TF) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA524Mu | ELISA Kit for Tissue Factor (TF) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCA524Mu | CLIA Kit for Tissue Factor (TF) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA524Ra01 | Recombinant Tissue Factor (TF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APA524Ra01 | Active Tissue Factor (TF) | Cell culture; Activity Assays. | |
| Antibodies | PAA524Ra01 | Polyclonal Antibody to Tissue Factor (TF) | WB; IHC; ICC; IP. |
| LAA524Ra71 | Biotin-Linked Polyclonal Antibody to Tissue Factor (TF) | WB; IHC; ICC. | |
| LAA524Ra81 | FITC-Linked Polyclonal Antibody to Tissue Factor (TF) | WB; IHC; ICC; IF. | |
| MAA524Ra21 | Monoclonal Antibody to Tissue Factor (TF) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA524Ra | ELISA Kit for Tissue Factor (TF) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Oryctolagus cuniculus (Rabbit)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA524Rb01 | Recombinant Tissue Factor (TF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA524Rb02 | Recombinant Tissue Factor (TF) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA524Rb52 | Polyclonal Antibody to Tissue Factor (TF) | WB; IHC; ICC; IP. |
| PAA524Rb51 | Polyclonal Antibody to Tissue Factor (TF) | WB; IHC; ICC; IP. | |
| LAA524Rb71 | Biotin-Linked Polyclonal Antibody to Tissue Factor (TF) | WB; IHC; ICC. | |
| MAA524Rb21 | Monoclonal Antibody to Tissue Factor (TF) | WB; IHC; ICC; IP. | |
| PAA524Rb01 | Polyclonal Antibody to Tissue Factor (TF) | WB; IHC; ICC; IP. | |
| MAA524Rb22 | Monoclonal Antibody to Tissue Factor (TF) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA524Rb | ELISA Kit for Tissue Factor (TF) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Sus scrofa; Porcine (Pig)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA524Po01 | Recombinant Tissue Factor (TF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA524Po01 | Polyclonal Antibody to Tissue Factor (TF) | WB; IHC; ICC; IP. |
| MAA524Po21 | Monoclonal Antibody to Tissue Factor (TF) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA524Po | ELISA Kit for Tissue Factor (TF) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Bos taurus; Bovine (Cattle)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA524Bo01 | Recombinant Tissue Factor (TF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA524Bo01 | Polyclonal Antibody to Tissue Factor (TF) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Tissue Factor (TF) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Tissue Factor (TF) | ELISA Kit Customized Service Offer |
- "Human tissue factor: cDNA sequence and chromosome localization of the gene."Biochemistry 26:5234-5238(1987) [PubMed] [Europe PMC] [Abstract]
- "Molecular cloning of the cDNA for tissue factor, the cellular receptor for the initiation of the coagulation protease cascade."Cell 50:129-135(1987) [PubMed] [Europe PMC] [Abstract]
- "Isolation of cDNA clones coding for human tissue factor: primary structure of the protein and cDNA."Proc. Natl. Acad. Sci. U.S.A. 84:5148-5152(1987) [PubMed] [Europe PMC] [Abstract]
- "Cloning and expression of human tissue factor cDNA."Thromb. Res. 48:89-99(1987) [PubMed] [Europe PMC] [Abstract]
- "Complete sequence of the human tissue factor gene, a highly regulated cellular receptor that initiates the coagulation protease cascade."Biochemistry 28:1755-1762(1989) [PubMed] [Europe PMC] [Abstract]
- "Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein."Nat. Med. 9:458-462(2003) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Human tissue factor contains thioester-linked palmitate and stearate on the cytoplasmic half-cystine."Biochemistry 27:4227-4231(1988) [PubMed] [Europe PMC] [Abstract]
- "Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells."Circ. Res. 104:589-599(2009) [PubMed] [Europe PMC] [Abstract]
- "Heparanase enhances the generation of activated factor X in the presence of tissue factor and activated factor VII."Haematologica 95:1927-1934(2010) [PubMed] [Europe PMC] [Abstract]
- "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
- "Structure of the extracellular domain of human tissue factor: location of the factor VIIa binding site."Biochemistry 33:10864-10870(1994) [PubMed] [Europe PMC] [Abstract]
- "The crystal structure of the extracellular domain of human tissue factor refined to 1.7-A resolution."J. Mol. Biol. 256:144-159(1996) [PubMed] [Europe PMC] [Abstract]
- "The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor."Nature 380:41-46(1996) [PubMed] [Europe PMC] [Abstract]
- "Structure of extracellular tissue factor complexed with factor VIIa inhibited with a BPTI mutant."J. Mol. Biol. 285:2089-2104(1999) [PubMed] [Europe PMC] [Abstract]