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Activating Transcription Factor 2 (ATF2)

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CREB2; CRE-BP1; HB16; TREB7; cAMP Responsive Element Binding Protein 2; Cyclic AMP-dependent transcription factor ATF-2; Histone acetyltransferase ATF2

Activating Transcription Factor 2 (ATF2)
CCC A502
HGNC 784
MGI 109349
PubMed 15916964
RGD 621862
UniProt P15336
Wiki ATF2

Activating transcription factor 2 is a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. The protein forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription.

The protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. Additional transcript variants have been identified but their biological validity has not been determined.The protein ATF-2 has 505 amino acids. Studies in mice indicate a role for ATF-2 in the development of nervous system and the skeleton.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Activating Transcription Factor 2 (ATF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Activating Transcription Factor 2 (ATF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Activating Transcription Factor 2 (ATF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Activating Transcription Factor 2 (ATF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Activating Transcription Factor 2 (ATF2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Activating Transcription Factor 2 (ATF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Activating Transcription Factor 2 (ATF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Activating Transcription Factor 2 (ATF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Activating Transcription Factor 2 (ATF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Activating Transcription Factor 2 (ATF2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Activating Transcription Factor 2 (ATF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Activating Transcription Factor 2 (ATF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Activating Transcription Factor 2 (ATF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Activating Transcription Factor 2 (ATF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Activating Transcription Factor 2 (ATF2) ELISA Kit Customized Service Offer
  1. "Leucine zipper structure of the protein CRE-BP1 binding to the cyclic AMP response element in brain."EMBO J. 8:2023-2028(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of a novel, spliced variant of CREB that is preferentially expressed in the thymus."J. Immunol. 158:2522-2525(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization and functional analysis of cAMP response element modulator protein and activating transcription factor 2 (ATF2) isoforms in the human myometrium during pregnancy and labor: identification of a novel ATF2 species with potent transactivation properties."J. Clin. Endocrinol. Metab. 87:1717-1728(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A cDNA for a human cyclic AMP response element-binding protein which is distinct from CREB and expressed preferentially in brain."Mol. Cell. Biol. 10:1347-1357(1990) [PubMed] [Europe PMC] [Abstract]
  7. "Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade."Proc. Natl. Acad. Sci. U.S.A. 93:10803-10808(1996) [PubMed] [Europe PMC] [Abstract]
  8. "Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6."J. Biol. Chem. 273:1741-1748(1998) [PubMed] [Europe PMC] [Abstract]
  9. "Characterization of functional domains of an embryonic stem cell coactivator UTF1 which are conserved and essential for potentiation of ATF-2 activity."J. Biol. Chem. 273:25840-25849(1998) [PubMed] [Europe PMC] [Abstract]
  10. "ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation."Nature 405:195-200(2000) [PubMed] [Europe PMC] [Abstract]
  11. "Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38."EMBO J. 21:3782-3793(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Human vaccinia-related kinase 1 (VRK1) activates the ATF2 transcriptional activity by novel phosphorylation on Thr-73 and Ser-62 and cooperates with JNK."J. Biol. Chem. 279:27458-27465(2004) [PubMed] [Europe PMC] [Abstract]
  13. "ATM-dependent phosphorylation of ATF2 is required for the DNA damage response."Mol. Cell 18:577-587(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Multiple roles for acetylation in the interaction of p300 HAT with ATF-2."Biochemistry 46:8207-8216(2007) [PubMed] [Europe PMC] [Abstract]
  15. "ATF2: a transcription factor that elicits oncogenic or tumor suppressor activities."Cell Cycle 7:2341-2345(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Regulation of TIP60 by ATF2 modulates ATM activation."J. Biol. Chem. 283:17605-17614(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  18. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  19. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Phosphorylation of activation transcription factor-2 at serine 121 by protein kinase c controls c-Jun-mediated activation of transcription."J. Biol. Chem. 284:8567-8581(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  23. "Hyperosmotic stress-induced ATF-2 activation through Polo-like kinase 3 in human corneal epithelial cells."J. Biol. Chem. 286:1951-1958(2011) [PubMed] [Europe PMC] [Abstract]
  24. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  25. "PKCepsilon promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria."Cell 148:543-555(2012) [PubMed] [Europe PMC] [Abstract]
  26. "Critical role of N-terminal end-localized nuclear export signal in regulation of activating transcription factor 2 (ATF2) subcellular localization and transcriptional activity."J. Biol. Chem. 287:8621-8632(2012) [PubMed] [Europe PMC] [Abstract]
  27. "ATF2-at the crossroad of nuclear and cytosolic functions."J. Cell Sci. 125:2815-2824(2012) [PubMed] [Europe PMC] [Abstract]
  28. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  29. "Solution structure of the transactivation domain of ATF-2 comprising a zinc finger-like subdomain and a flexible subdomain."J. Mol. Biol. 287:593-607(1999) [PubMed] [Europe PMC] [Abstract]
  30. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]