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Synaptophysin is a synaptic vesicle glycoprotein with four transmembrane domains weighing 38kDa. It is present in neuroendocrine cells and in virtually all neurons in the brain and spinal cord that participate in synaptic transmission. It acts as a marker for neuroendocrine tumors, and its ubiquity at the synapse has lead to the use of synaptophysin immunostaining for quantification of synapses.
The exact function of the protein is unknown: it interacts with the essential synaptic vesicle protein synaptobrevin, but when the synaptophysin gene is experimentally inactivated in animals, they still develop and function normally.Synaptophysin can refer both to the vesicle membrane protein.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA425Hu01 | Recombinant Synaptophysin (SYP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| CPA425Hu21 | OVA Conjugated Synaptophysin (SYP) | Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA425Hu01 | Polyclonal Antibody to Synaptophysin (SYP) | WB; IHC; ICC; IP. |
| MAA425Hu22 | Monoclonal Antibody to Synaptophysin (SYP) | WB; IHC; ICC; IP. | |
| PAA425Hu08 | Polyclonal Antibody to Synaptophysin (SYP) | WB; IHC; ICC; IP. | |
| LAA425Hu61 | Cy3-Linked Polyclonal Antibody to Synaptophysin (SYP) | WB; IHC; ICC; IF. | |
| PAA425Mi08 | Polyclonal Antibody to Synaptophysin (SYP) | WB; IHC | |
| MAA425Hu21 | Monoclonal Antibody to Synaptophysin (SYP) | WB; IHC; ICC; IP. | |
| PAA425Hu02 | Polyclonal Antibody to Synaptophysin (SYP) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA425Hu | ELISA Kit for Synaptophysin (SYP) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| CEA425Hu | ELISA Kit for Synaptophysin (SYP) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA425Mu01 | Recombinant Synaptophysin (SYP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA425Mu02 | Recombinant Synaptophysin (SYP) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA425Mu01 | Polyclonal Antibody to Synaptophysin (SYP) | WB; IHC; ICC; IP. |
| PAA425Mu02 | Polyclonal Antibody to Synaptophysin (SYP) | WB; IHC; ICC; IP. | |
| PAA425Mi08 | Polyclonal Antibody to Synaptophysin (SYP) | WB; IHC | |
| Assay Kits | SEA425Mu | ELISA Kit for Synaptophysin (SYP) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| CEA425Mu | ELISA Kit for Synaptophysin (SYP) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Synaptophysin (SYP) | Recombinant Protein Customized Service Offer |
| Antibodies | PAA425Mi08 | Polyclonal Antibody to Synaptophysin (SYP) | WB; IHC |
| Assay Kits | CEA425Ra | ELISA Kit for Synaptophysin (SYP) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SEA425Ra | ELISA Kit for Synaptophysin (SYP) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Bos taurus; Bovine (Cattle)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA425Bo01 | Recombinant Synaptophysin (SYP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA425Bo01 | Polyclonal Antibody to Synaptophysin (SYP) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Synaptophysin (SYP) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Synaptophysin (SYP) | ELISA Kit Customized Service Offer |
- "The cDNA and derived amino acid sequences for rat and human synaptophysin."Nucleic Acids Res. 15:9607-9607(1987) [PubMed] [Europe PMC] [Abstract]
- "Synaptophysin: structure of the human gene and assignment to the X chromosome in man and mouse."Am. J. Hum. Genet. 47:551-561(1990) [PubMed] [Europe PMC] [Abstract]
- "Sequence-based exon prediction around the synaptophysin locus reveals a gene-rich area containing novel genes in human proximal Xp."Genomics 45:340-347(1997) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Characterization of a multidomain adaptor protein, p140Cap, as part of a pre-synaptic complex."J. Neurochem. 107:61-72(2008) [PubMed] [Europe PMC] [Abstract]
- "A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation." Nat. Genet. 41:535-543(2009) [PubMed] [Europe PMC] [Abstract]