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Gelsolin (GSN)

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GS; AGEL; ADF; Brevin; Gelsolin Amyloidosis,Finnish Type; Actin-depolymerizing factor

Gelsolin (GSN)
CCC A372
HGNC 4620
MGI 95851
PubMed 10880956
RGD 1303089
UniProt P06396
Wiki Gelsolin

Gelsolin is an actin-regulatory protein that modulates actin assembly and disassembly, and is believed to regulate cell motility in vivo through modulation of the actin network. In addition to its actin-regulatory function, gelsolin has also been proposed to affect cell growth.It is first isolated from rabbit lung macrophages as a modulator of the cytoplasmic actin gel−sol transformation. Gelsolin can sever actin filaments and cap the fast-growing ends of the filaments in vitro; this promotes actin disassembly. Gelsolin also has the ability to nucleate actin polymerization. These functions are activated by Ca2 and inhibited by polyphosphoinositides (PPIs). Such observations have led to the view that gelsolin regulates actin reorganization in response to changes in the concentrations of Ca2 and PPIs in living cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA372Hu01 Recombinant Gelsolin (GSN) Positive Control; Immunogen; SDS-PAGE; WB.
RPA372Hu02 Recombinant Gelsolin (GSN) Positive Control; Immunogen; SDS-PAGE; WB.
RPA372Hu03 Recombinant Gelsolin (GSN) Positive Control; Immunogen; SDS-PAGE; WB.
RPA372Hu04 Recombinant Gelsolin (GSN) Positive Control; Immunogen; SDS-PAGE; WB.
CPA372Hu21 OVA Conjugated Gelsolin (GSN) Immunogen; SDS-PAGE; WB.
RPA372Hu05 Recombinant Gelsolin (GSN) Positive Control; Immunogen; SDS-PAGE; WB.
RPA372Hu06 Recombinant Gelsolin (GSN) Positive Control; Immunogen; SDS-PAGE; WB.
EPA372Hu61 Eukaryotic Gelsolin (GSN) Positive Control; Immunogen; SDS-PAGE; WB.
APA372Hu61 Active Gelsolin (GSN) Cell culture; Activity Assays.
Antibodies PAA372Hu01 Polyclonal Antibody to Gelsolin (GSN) WB; IHC; ICC; IP.
MAA372Hu22 Monoclonal Antibody to Gelsolin (GSN) WB; IHC; ICC; IP.
LAA372Hu71 Biotin-Linked Polyclonal Antibody to Gelsolin (GSN) WB; IHC; ICC.
PAA372Hu02 Polyclonal Antibody to Gelsolin (GSN) WB; IHC; ICC; IP.
PAA372Hu03 Polyclonal Antibody to Gelsolin (GSN) WB; IHC; ICC; IP.
PAA372Hu04 Polyclonal Antibody to Gelsolin (GSN) WB; IHC; ICC; IP.
PAA372Hu08 Polyclonal Antibody to Gelsolin (GSN) WB; IHC; ICC; IP.
PAA372Hu05 Polyclonal Antibody to Gelsolin (GSN) WB; IHC; ICC; IP.
MAA372Hu24 Monoclonal Antibody to Gelsolin (GSN) WB; IHC
MAA372Hu21 Monoclonal Antibody to Gelsolin (GSN) WB; IHC; ICC; IP.
MAA372Hu23 Monoclonal Antibody to Gelsolin (GSN) WB; IHC; ICC; IP.
MAA372Hu25 Monoclonal Antibody to Gelsolin (GSN) WB; IHC; ICC; IP.
MAA372Hu27 Monoclonal Antibody to Gelsolin (GSN) WB; IHC; ICC; IP.
MAA372Hu29 Monoclonal Antibody to Gelsolin (GSN) WB; IHC; ICC; IP.
MAA372Hu26 Monoclonal Antibody to Gelsolin (GSN) WB; IHC; ICC; IP.
PAA372Hu06 Polyclonal Antibody to Gelsolin (GSN) WB; IHC; ICC; IP.
Assay Kits SEA372Hu ELISA Kit for Gelsolin (GSN) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA372Hu CLIA Kit for Gelsolin (GSN) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA372Mu01 Recombinant Gelsolin (GSN) Positive Control; Immunogen; SDS-PAGE; WB.
RPA372Mu02 Recombinant Gelsolin (GSN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA372Mu01 Polyclonal Antibody to Gelsolin (GSN) WB; IHC; ICC; IP.
PAA372Mu02 Polyclonal Antibody to Gelsolin (GSN) WB; IHC; ICC; IP.
Assay Kits SEA372Mu ELISA Kit for Gelsolin (GSN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA372Ra01 Recombinant Gelsolin (GSN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA372Ra01 Polyclonal Antibody to Gelsolin (GSN) WB; IHC; ICC; IP.
LAA372Ra71 Biotin-Linked Polyclonal Antibody to Gelsolin (GSN) WB; IHC; ICC.
LAA372Ra81 FITC-Linked Polyclonal Antibody to Gelsolin (GSN) WB; IHC; ICC; IF.
Assay Kits SEA372Ra ELISA Kit for Gelsolin (GSN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rhesus monkey (Simian)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA372Si01 Recombinant Gelsolin (GSN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA372Si01 Polyclonal Antibody to Gelsolin (GSN) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Gelsolin (GSN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Gelsolin (GSN) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA372Bo01 Recombinant Gelsolin (GSN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA372Bo01 Polyclonal Antibody to Gelsolin (GSN) WB; IHC; ICC; IP.
MAA372Bo21 Monoclonal Antibody to Gelsolin (GSN) WB; IHC; ICC; IP.
Assay Kits SEA372Bo ELISA Kit for Gelsolin (GSN) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Plasma and cytoplasmic gelsolins are encoded by a single gene and contain a duplicated actin-binding domain."Nature 323:455-458(1986) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Human plasma gelsolin binds to fibronectin."J. Biol. Chem. 259:13262-13266(1984) [PubMed] [Europe PMC] [Abstract]
  7. "Amyloid protein in familial amyloidosis (Finnish type) is homologous to gelsolin, an actin-binding protein."Biochem. Biophys. Res. Commun. 167:927-932(1990) [PubMed] [Europe PMC] [Abstract]
  8. "Finnish hereditary amyloidosis. Amino acid sequence homology between the amyloid fibril protein and human plasma gelsoline."FEBS Lett. 260:85-87(1990) [PubMed] [Europe PMC] [Abstract]
  9. "The plasma and cytoplasmic forms of human gelsolin differ in disulfide structure."Biochemistry 35:9700-9709(1996) [PubMed] [Europe PMC] [Abstract]
  10. "Functional consequences of disulfide bond formation in gelsolin."FEBS Lett. 401:89-94(1997) [PubMed] [Europe PMC] [Abstract]
  11. "Identification of Tyr438 as the major in vitro c-Src phosphorylation site in human gelsolin: a mass spectrometric approach."Protein Sci. 8:234-241(1999) [PubMed] [Europe PMC] [Abstract]
  12. "Functional genomic screen for modulators of ciliogenesis and cilium length."Nature 464:1048-1051(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  15. "Structure of gelsolin segment 1-actin complex and the mechanism of filament severing."Nature 364:685-692(1993) [PubMed] [Europe PMC] [Abstract]
  16. "Spectroscopic studies of a phosphoinositide-binding peptide from gelsolin: behavior in solutions of mixed solvent and anionic micelles."Biophys. J. 69:2695-2702(1995) [PubMed] [Europe PMC] [Abstract]
  17. "Calcium ion exchange in crystalline gelsolin."J. Mol. Biol. 357:773-782(2006) [PubMed] [Europe PMC] [Abstract]
  18. "Structural states and dynamics of the D-loop in actin."Biophys. J. 103:930-939(2012) [PubMed] [Europe PMC] [Abstract]
  19. "Gelsolin variant (Asn-187) in familial amyloidosis, Finnish type."Biochem. J. 272:827-830(1990) [PubMed] [Europe PMC] [Abstract]
  20. "Gelsolin-derived familial amyloidosis caused by asparagine or tyrosine substitution for aspartic acid at residue 187."Nat. Genet. 2:157-160(1992) [PubMed] [Europe PMC] [Abstract]
  21. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]