≡

Chemokine (C-X-C motif) ligand 7 ( CXCL7)

[Edit]

CXCL7; PPBP; PBP; B-TG1; CTAP-III; CTAP3; CTAPIII; LA-PF4; LDGF; MDGF; NAP2; SCYB7; TC1; TC2; TGB1; THBGB1; Pro-Platelet Basic Protein; Beta-Thromboglobulin

Chemokine (C-X-C motif) ligand 7 ( CXCL7)
CCC A370
HGNC 9240
MGI 1888712
PubMed 6183969
RGD 70548
UniProt P02775
Wiki CXCL7

Chemokine (C-X-C motif) ligand 7 (CXCL7) is a platelet-derived growth factor that belongs to the CXC chemokine family. It is an isoform of Beta-Thromboglobulin or Pro-Platelet basic protein (PPBP).

Beta-thromboglobulin (β-TG) has a molecular weight of 35000 daltons and is a specific protein of platelets. Composed of 4 identical subunits; It is synthesized in the cells as a biologically inactive 15 kDa precursor called PBP (platelet basic protein). It is stored in the Alpha-granules of platelets and released in large amounts after platelet activation.It is a protein that is released in large amounts from platelets following their activation. It stimulates various processes including mitogenesis, synthesis of extracellular matrix, glucose metabolism and synthesis of plasminogen activator.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA370Hu01 Recombinant Chemokine (C-X-C motif) ligand 7 ( CXCL7) Positive Control; Immunogen; SDS-PAGE; WB.
APA370Hu01 Active Chemokine (C-X-C motif) ligand 7 ( CXCL7) Cell culture; Activity Assays.
Antibodies PAA370Hu01 Polyclonal Antibody to Chemokine (C-X-C motif) ligand 7 ( CXCL7) WB; IHC; ICC; IP.
MAA370Hu22 Monoclonal Antibody to Chemokine (C-X-C motif) ligand 7 ( CXCL7) WB; IHC; ICC; IP.
LAA370Hu71 Biotin-Linked Polyclonal Antibody to Chemokine (C-X-C motif) ligand 7 ( CXCL7) WB; IHC; ICC.
LAA370Hu81 FITC-Linked Polyclonal Antibody to Chemokine (C-X-C motif) ligand 7 ( CXCL7) WB; IHC; ICC; IF.
LAA370Hu72 Biotin-Linked Monoclonal Antibody to Chemokine (C-X-C motif) ligand 7 ( CXCL7) WB; IHC; ICC.
LAA370Hu82 FITC-Linked Monoclonal Antibody to Chemokine (C-X-C motif) ligand 7 ( CXCL7) WB; IHC; ICC; IF.
MAA370Hu24 Monoclonal Antibody to Chemokine (C-X-C motif) ligand 7 ( CXCL7) WB; IHC; ICC; IP.
LAA370Hu74 Biotin-Linked Monoclonal Antibody to Chemokine (C-X-C motif) ligand 7 ( CXCL7) WB; IHC; ICC.
MAA370Hu26 Monoclonal Antibody to Chemokine (C-X-C motif) ligand 7 ( CXCL7) WB; IHC; ICC; IP.
LAA370Hu76 Biotin-Linked Monoclonal Antibody to Chemokine (C-X-C motif) ligand 7 ( CXCL7) WB; IHC; ICC.
MAA370Hu21 Monoclonal Antibody to Chemokine (C-X-C motif) ligand 7 ( CXCL7) WB; IHC; ICC; IP.
MAA370Hu23 Monoclonal Antibody to Chemokine (C-X-C motif) ligand 7 ( CXCL7) WB; IHC; ICC; IP.
MAA370Hu28 Monoclonal Antibody to Chemokine (C-X-C motif) ligand 7 ( CXCL7) WB; IHC; ICC; IP.
MAA370Hu25 Monoclonal Antibody to Chemokine (C-X-C motif) ligand 7 ( CXCL7) WB; IHC; ICC; IP.
MAA370Hu27 Monoclonal Antibody to Chemokine (C-X-C motif) ligand 7 ( CXCL7) WB; IHC; ICC; IP.
Assay Kits SEA370Hu ELISA Kit for Chemokine (C-X-C motif) ligand 7 ( CXCL7) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA370Mu01 Recombinant Chemokine (C-X-C motif) ligand 7 ( CXCL7) Positive Control; Immunogen; SDS-PAGE; WB.
RPA370Mu02 Recombinant Chemokine (C-X-C motif) ligand 7 ( CXCL7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA370Mu01 Polyclonal Antibody to Chemokine (C-X-C motif) ligand 7 ( CXCL7) WB; IHC; ICC; IP.
LAA370Mu71 Biotin-Linked Polyclonal Antibody to Chemokine (C-X-C motif) ligand 7 ( CXCL7) WB; IHC; ICC.
LAA370Mu81 FITC-Linked Polyclonal Antibody to Chemokine (C-X-C motif) ligand 7 ( CXCL7) WB; IHC; ICC; IF.
PAA370Mu02 Polyclonal Antibody to Chemokine (C-X-C motif) ligand 7 ( CXCL7) WB; IHC; ICC; IP.
Assay Kits SEA370Mu ELISA Kit for Chemokine (C-X-C motif) ligand 7 ( CXCL7) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA370Ra01 Recombinant Chemokine (C-X-C motif) ligand 7 ( CXCL7) Positive Control; Immunogen; SDS-PAGE; WB.
RPA370Ra02 Recombinant Chemokine (C-X-C motif) ligand 7 ( CXCL7) Positive Control; Immunogen; SDS-PAGE; WB.
APA370Ra01 Active Chemokine (C-X-C motif) ligand 7 ( CXCL7) Cell culture; Activity Assays.
Antibodies PAA370Ra01 Polyclonal Antibody to Chemokine (C-X-C motif) ligand 7 ( CXCL7) WB; IHC; ICC; IP.
MAA370Ra22 Monoclonal Antibody to Chemokine (C-X-C motif) ligand 7 ( CXCL7) WB; IHC; ICC; IP.
LAA370Ra71 Biotin-Linked Polyclonal Antibody to Chemokine (C-X-C motif) ligand 7 ( CXCL7) WB; IHC; ICC.
LAA370Ra81 FITC-Linked Polyclonal Antibody to Chemokine (C-X-C motif) ligand 7 ( CXCL7) WB; IHC; ICC; IF.
PAA370Ra02 Polyclonal Antibody to Chemokine (C-X-C motif) ligand 7 ( CXCL7) WB; IHC; ICC; IP.
Assay Kits SEA370Ra ELISA Kit for Chemokine (C-X-C motif) ligand 7 ( CXCL7) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA370Ra CLIA Kit for Chemokine (C-X-C motif) ligand 7 ( CXCL7) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA370Rb01 Recombinant Chemokine (C-X-C motif) ligand 7 ( CXCL7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA370Rb01 Polyclonal Antibody to Chemokine (C-X-C motif) ligand 7 ( CXCL7) WB; IHC; ICC; IP.
Assay Kits SEA370Rb ELISA Kit for Chemokine (C-X-C motif) ligand 7 ( CXCL7) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chemokine (C-X-C motif) ligand 7 ( CXCL7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chemokine (C-X-C motif) ligand 7 ( CXCL7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chemokine (C-X-C motif) ligand 7 ( CXCL7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chemokine (C-X-C motif) ligand 7 ( CXCL7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chemokine (C-X-C motif) ligand 7 ( CXCL7) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA370Po01 Recombinant Chemokine (C-X-C motif) ligand 7 ( CXCL7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA370Po01 Polyclonal Antibody to Chemokine (C-X-C motif) ligand 7 ( CXCL7) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Chemokine (C-X-C motif) ligand 7 ( CXCL7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chemokine (C-X-C motif) ligand 7 ( CXCL7) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chemokine (C-X-C motif) ligand 7 ( CXCL7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chemokine (C-X-C motif) ligand 7 ( CXCL7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chemokine (C-X-C motif) ligand 7 ( CXCL7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chemokine (C-X-C motif) ligand 7 ( CXCL7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chemokine (C-X-C motif) ligand 7 ( CXCL7) ELISA Kit Customized Service Offer
  1. "Cloning of cDNA coding for connective tissue activating peptide III from a human platelet-derived lambda gt11 expression library."Blood 73:1498-1503(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of the human beta-thromboglobulin gene. Comparison with the gene for platelet factor 4."J. Biol. Chem. 266:5785-5789(1991) [PubMed] [Europe PMC] [Abstract]
  3. "Localization of distal regulatory domains in the megakaryocyte-specific platelet basic protein/platelet factor 4 gene locus."Blood 98:610-617(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Characterization of human platelet basic protein, a precursor form of low-affinity platelet factor 4 and beta-thromboglobulin."Biochemistry 25:1988-1996(1986) [PubMed] [Europe PMC] [Abstract]
  8. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Thrombocidins, microbicidal proteins from human blood platelets, are C-terminal deletion products of CXC chemokines."J. Biol. Chem. 275:20374-20381(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Structural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor."Proc. Natl. Acad. Sci. U.S.A. 80:765-769(1983) [PubMed] [Europe PMC] [Abstract]
  11. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Complete covalent structure of human beta-thromboglobulin."Biochemistry 17:1739-1744(1978) [PubMed] [Europe PMC] [Abstract]
  13. "Thrombin-activated human platelets release two NAP-2 variants that stimulate polymorphonuclear leukocytes."Thromb. Haemost. 76:780-785(1996) [PubMed] [Europe PMC] [Abstract]
  14. "Connective tissue activation. XXXIII. Biologically active cleavage products of CTAP-III from human platelets."Biochem. Biophys. Res. Commun. 163:1071-1078(1989) [PubMed] [Europe PMC] [Abstract]
  15. "A novel cleavage product of beta-thromboglobulin formed in cultures of stimulated mononuclear cells activates human neutrophils."Biochem. Biophys. Res. Commun. 159:969-975(1989) [PubMed] [Europe PMC] [Abstract]
  16. "Limited and defined truncation at the C-terminus enhances receptor binding and degranulation activity of the neutrophil-activating peptide 2 (NAP-2). Comparison of native and recombinant NAP-2 variants."J. Biol. Chem. 270:6338-6344(1995) [PubMed] [Europe PMC] [Abstract]
  17. "Generation of the neutrophil-activating peptide NAP-2 from platelet basic protein or connective tissue-activating peptide III through monocyte proteases."J. Exp. Med. 171:449-454(1990) [PubMed] [Europe PMC] [Abstract]
  18. "Chemical synthesis, purification, and characterization of two inflammatory proteins, neutrophil activating peptide 1 (interleukin-8) and neutrophil activating peptide."Biochemistry 30:3128-3135(1991) [PubMed] [Europe PMC] [Abstract]
  19. "Novel C-terminally truncated isoforms of the CXC chemokine beta-thromboglobulin and their impact on neutrophil functions."J. Immunol. 161:4975-4982(1998) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  21. "Purification, crystallization and preliminary X-ray diffraction analysis of recombinant human neutrophil-activating peptide 2 (rhNAP-2)."FEBS Lett. 347:300-303(1994) [PubMed] [Europe PMC] [Abstract]
  22. "The crystal structure of recombinant human neutrophil-activating peptide-2 (M6L) at 1.9-A resolution."J. Biol. Chem. 270:7077-7087(1995) [PubMed] [Europe PMC] [Abstract]