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Collagen Type I Alpha 1 (COL1a1)

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COL-1A1; COL1-A1; COL1A-1; OI4; Collagen Alpha-1(I)chain

Collagen Type I Alpha 1 (COL1a1)
CCC A350
HGNC 2197
MGI 88467
PubMed 12810179
RGD 61817
UniProt P02452
Wiki COL1A1

Collagen, type I, alpha 1 is the major component of type I collagen, the fibrillar collagen found in most connective tissues, including cartilage.

The COL1A1 gene produces a component of type I collagen, called the pro-alpha1(I) chain. This chain combines with another pro-alpha1(I) chain and also with a pro-alpha2(I) chain (produced by the COL1A2 gene) to make a molecule of type I procollagen. These triple-stranded, rope-like procollagen molecules must be processed by enzymes outside the cell. Once these molecules are processed, they arrange themselves into long, thin fibrils that cross-link to one another in the spaces around cells. The cross-links result in the formation of very strong mature type I collagen fibers.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA350Hu01 Recombinant Collagen Type I Alpha 1 (COL1a1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA350Hu02 Recombinant Collagen Type I Alpha 1 (COL1a1) Positive Control; Immunogen; SDS-PAGE; WB.
CPA350Hu11 BSA Conjugated Collagen Type I Alpha 1 (COL1a1) Immunogen; SDS-PAGE; WB.
CPA350Hu21 OVA Conjugated Collagen Type I Alpha 1 (COL1a1) Immunogen; SDS-PAGE; WB.
RPA350Hu03 Recombinant Collagen Type I Alpha 1 (COL1a1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA350Hu04 Recombinant Collagen Type I Alpha 1 (COL1a1) Positive Control; Immunogen; SDS-PAGE; WB.
EPA350Hu61 Eukaryotic Collagen Type I Alpha 1 (COL1a1) Positive Control; Immunogen; SDS-PAGE; WB.
APA350Hu61 Active Collagen Type I Alpha 1 (COL1a1) Cell culture; Activity Assays.
EPA350Hu62 Eukaryotic Collagen Type I Alpha 1 (COL1a1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAA350Hu22 Monoclonal Antibody to Collagen Type I Alpha 1 (COL1a1) WB
PAA350Hu02 Polyclonal Antibody to Collagen Type I Alpha 1 (COL1a1) WB
PAA350Hu01 Polyclonal Antibody to Collagen Type I Alpha 1 (COL1a1) WB; IHC; ICC; IP.
PAA350Hu08 Polyclonal Antibody to Collagen Type I Alpha 1 (COL1a1) WB; IHC; ICC; IP.
MAA350Hu21 Monoclonal Antibody to Collagen Type I Alpha 1 (COL1a1) WB; IHC
PAA350Hu03 Polyclonal Antibody to Collagen Type I Alpha 1 (COL1a1) WB; IHC; ICC; IP.
PAA350Hu04 Polyclonal Antibody to Collagen Type I Alpha 1 (COL1a1) WB; IHC; ICC; IP.
MAA350Hu23 Monoclonal Antibody to Collagen Type I Alpha 1 (COL1a1) WB; IHC; ICC; IP.
Assay Kits SEA350Hu ELISA Kit for Collagen Type I Alpha 1 (COL1a1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA350Mu01 Recombinant Collagen Type I Alpha 1 (COL1a1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA350Mu02 Recombinant Collagen Type I Alpha 1 (COL1a1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA350Mu01 Polyclonal Antibody to Collagen Type I Alpha 1 (COL1a1) WB; IHC; ICC; IP.
LAA350Mu71 Biotin-Linked Polyclonal Antibody to Collagen Type I Alpha 1 (COL1a1) WB; IHC; ICC.
PAA350Mu02 Polyclonal Antibody to Collagen Type I Alpha 1 (COL1a1) WB; IHC; ICC; IP.
Assay Kits SEA350Mu ELISA Kit for Collagen Type I Alpha 1 (COL1a1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA350Ra01 Recombinant Collagen Type I Alpha 1 (COL1a1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA350Ra01 Polyclonal Antibody to Collagen Type I Alpha 1 (COL1a1) WB; IHC; ICC; IP.
MAA350Ra21 Monoclonal Antibody to Collagen Type I Alpha 1 (COL1a1) WB; IHC; ICC; IP.
Assay Kits SEA350Ra ELISA Kit for Collagen Type I Alpha 1 (COL1a1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Analysis of the COL1A1 and COL1A2 genes by PCR amplification and scanning by conformation-sensitive gel electrophoresis identifies only COL1A1 mutations in 15 patients with osteogenesis imperfecta type I: identification of common sequences of null-allele mutations."Am. J. Hum. Genet. 62:98-110(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete nucleotide sequence of the region encompassing the first twenty-five exons of the human pro alpha 1(I) collagen gene (COL1A1)."Gene 67:105-115(1988) [PubMed] [Europe PMC] [Abstract]
  4. "Structure of a full-length cDNA clone for the prepro alpha 1(I) chain of human type I procollagen."Biochem. J. 253:919-922(1988) [PubMed] [Europe PMC] [Abstract]
  5. "Human pro alpha 1(I) collagen gene structure reveals evolutionary conservation of a pattern of introns and exons."Nature 310:337-340(1984) [PubMed] [Europe PMC] [Abstract]
  6. "DNA sequences in the first intron of the human pro-alpha 1(I) collagen gene enhance transcription."J. Biol. Chem. 262:15151-15157(1987) [PubMed] [Europe PMC] [Abstract]
  7. "Fine structural analysis of the human pro-alpha 1 (I) collagen gene. Promoter structure, AluI repeats, and polymorphic transcripts."J. Biol. Chem. 260:2315-2320(1985) [PubMed] [Europe PMC] [Abstract]
  8. "Regulatory elements in the first intron contribute to transcriptional control of the human alpha 1(I) collagen gene."Proc. Natl. Acad. Sci. U.S.A. 84:8869-8873(1987) [PubMed] [Europe PMC] [Abstract]
  9. "In vivo and in vitro noncovalent association of excised alpha 1 (I) amino-terminal propeptides with mutant pN alpha 2(I) collagen chains in native mutant collagen in a case of Ehlers-Danlos syndrome, type VII."J. Biol. Chem. 265:6312-6317(1990) [PubMed] [Europe PMC] [Abstract]
  10. "A base substitution in the exon of a collagen gene causes alternative splicing and generates a structurally abnormal polypeptide in a patient with Ehlers-Danlos syndrome type VII."EMBO J. 8:1705-1710(1989) [PubMed] [Europe PMC] [Abstract]
  11. "Isolation and characterization of the cyanogen bromide peptides from the alpha 1 and alpha 2 chains of human skin collagen."Biochemistry 9:4699-4706(1970) [PubMed] [Europe PMC] [Abstract]
  12. "A critical crosslink region in human-bone-derived collagen type I. Specific cleavage site at residue Leu95."Eur. J. Biochem. 192:153-159(1990) [PubMed] [Europe PMC] [Abstract]
  13. "A comparative study of glycopeptides derived from selected vertebrate collagens. A possible role of the carbohydrate in fibril formation."J. Biol. Chem. 245:5042-5048(1970) [PubMed] [Europe PMC] [Abstract]
  14. "Segmental amplification of the entire helical and telopeptide regions of the cDNA for human alpha 1 (I) collagen."Matrix 10:124-130(1990) [PubMed] [Europe PMC] [Abstract]
  15. "Nucleotide sequences of complementary deoxyribonucleic acids for the pro alpha 1 chain of human type I procollagen. Statistical evaluation of structures that are conserved during evolution."Biochemistry 22:5213-5223(1983) [PubMed] [Europe PMC] [Abstract]
  16. "Cloning and characterization of five overlapping cDNAs specific for the human pro alpha 1(I) collagen chain."Nucleic Acids Res. 10:5925-5934(1982) [PubMed] [Europe PMC] [Abstract]
  17. "Multiexon deletion in an osteogenesis imperfecta variant with increased type III collagen mRNA."J. Biol. Chem. 260:691-694(1985) [PubMed] [Europe PMC] [Abstract]
  18. "Intron-mediated recombination may cause a deletion in an alpha 1 type I collagen chain in a lethal form of osteogenesis imperfecta."Proc. Natl. Acad. Sci. U.S.A. 82:2870-2874(1985) [PubMed] [Europe PMC] [Abstract]
  19. "Variable expression of osteogenesis imperfecta in a nuclear family is explained by somatic mosaicism for a lethal point mutation in the alpha 1(I) gene (COL1A1) of type I collagen in a parent."Am. J. Hum. Genet. 46:1034-1040(1990) [PubMed] [Europe PMC] [Abstract]
  20. "Severe (type III) osteogenesis imperfecta due to glycine substitutions in the central domain of the collagen triple helix."Hum. Mol. Genet. 3:2201-2206(1994) [PubMed] [Europe PMC] [Abstract]