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Prostaglandin E Receptor 3 (EP3)

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PTGER3; EP3-I; EP3-II; EP3-III; EP3-IV; EP3e; PGE2 receptor EP3 subtype; Prostanoid EP3 receptor

Prostaglandin E Receptor 3 (EP3)
CCC A287
HGNC 9595
MGI 97795
PubMed 9154343
RGD 3435
UniProt P43115
Wiki PTGER3

Prostaglandin E receptor 3, also known as EP3, is a prostaglandin receptor, The receptor is a member of the G-protein coupled receptor family. It is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. In the stomach, it inhibits gastric acid secretions.

Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli.Multiple alternatively spliced transcript variants encoding eight distinct isoforms have been reported.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA287Hu01 Recombinant Prostaglandin E Receptor 3 (EP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA287Hu01 Polyclonal Antibody to Prostaglandin E Receptor 3 (EP3) WB; ICC; IHC-P; IHC-F; ELISA.
Assay Kits n/a CLIA Kit for Prostaglandin E Receptor 3 (EP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prostaglandin E Receptor 3 (EP3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Prostaglandin E Receptor 3 (EP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Prostaglandin E Receptor 3 (EP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Prostaglandin E Receptor 3 (EP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Prostaglandin E Receptor 3 (EP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prostaglandin E Receptor 3 (EP3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Prostaglandin E Receptor 3 (EP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Prostaglandin E Receptor 3 (EP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Prostaglandin E Receptor 3 (EP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Prostaglandin E Receptor 3 (EP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prostaglandin E Receptor 3 (EP3) ELISA Kit Customized Service Offer
  1. "Cloning and expression of three isoforms of the human EP3 prostanoid receptor."FEBS Lett. 338:170-174(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Splice variants of the human EP3 receptor for prostaglandin E2."Eur. J. Biochem. 228:23-30(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and expression of the EP3-subtype of human receptors for prostaglandin E2."Biochem. Biophys. Res. Commun. 198:999-1006(1994) [PubMed] [Europe PMC] [Abstract]
  4. "Cloning and expression of a prostaglandin E receptor EP3 subtype from human erythroleukaemia cells."Biochem. J. 298:263-267(1994) [PubMed] [Europe PMC] [Abstract]
  5. "Isoforms of the EP3 subtype of human prostaglandin E2 receptor transduce both intracellular calcium and cAMP signals."Biochemistry 33:14496-14502(1994) [PubMed] [Europe PMC] [Abstract]
  6. "Molecular cloning and expression of multiple isoforms of human prostaglandin E receptor EP3 subtype generated by alternative messenger RNA splicing: multiple second messenger systems and tissue-specific distributions."Mol. Pharmacol. 48:869-879(1995) [PubMed] [Europe PMC] [Abstract]
  7. "Molecular cloning and expression of human EP3 receptors: evidence of three variants with differing carboxyl termini."Br. J. Pharmacol. 112:377-385(1994) [PubMed] [Europe PMC] [Abstract]
  8. "Structural organization of the human prostaglandin EP3 receptor subtype gene (PTGER3)."Genomics 40:425-434(1997) [PubMed] [Europe PMC] [Abstract]
  9. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome." Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
  11. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  12. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  13. "A new mRNA splice variant coding for the human EP3-I receptor isoform."Prostaglandins Leukot. Essent. Fatty Acids 77:195-201(2007) [PubMed] [Europe PMC] [Abstract]