≡

Poly ADP Ribose Polymerase (PARP)

[Edit]

PARP1; ADPRT; ADPRT1; PPOL; pADPRT-1; ADP-ribosyltransferase diphtheria toxin-like 1; NAD(+) ADP-ribosyltransferase 1

Poly ADP Ribose Polymerase (PARP)
CCC A279
HGNC 270
MGI 1340806
PubMed 16123586
RGD 2053
UniProt P09874
Wiki PARP1
is a protein involved in a number of cellular processes involving mainly DNA repair and programmed cell death.RP, a 116 kDa nuclear poly (ADP-ribose) polymerase, appears to be involved in DNA repair in response to environmental stress . This protein can be cleaved by many ICE-like caspases in vitroand is one of the main cleavage targets of caspase-3 in vivo . In human PARP, the cleavage occurs between Asp214 and Gly215, which separates the PARP amino-terminal DNA binding domain (24 kDa) from the carboxy-terminal catalytic domain (89 kDa) .
PARP1 is a chromatin-associated enzyme, poly-ADP ribose polymerase-1, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. PARP1 has a role in repair of single-stranded DNA (ssDNA) breaks.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA279Hu01 Recombinant Poly ADP Ribose Polymerase (PARP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA279Hu01 Polyclonal Antibody to Poly ADP Ribose Polymerase (PARP) WB,ICC/IF
MAA279Hu21 Monoclonal Antibody to Poly ADP Ribose Polymerase (PARP) WB
MAA279Hu22 Monoclonal Antibody to Poly ADP Ribose Polymerase (PARP) WB; IHC; ICC; IP.
MAA279Hu23 Monoclonal Antibody to Poly ADP Ribose Polymerase (PARP) WB; IHC; ICC; IP.
MAA279Hu24 Monoclonal Antibody to Poly ADP Ribose Polymerase (PARP) WB; IHC; ICC; IP.
MAA279Hu25 Monoclonal Antibody to Poly ADP Ribose Polymerase (PARP) WB; IHC; ICC; IP.
Assay Kits SEA279Hu ELISA Kit for Poly ADP Ribose Polymerase (PARP) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA279Hu CLIA Kit for Poly ADP Ribose Polymerase (PARP) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA279Mu01 Recombinant Poly ADP Ribose Polymerase (PARP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA279Mu01 Polyclonal Antibody to Poly ADP Ribose Polymerase (PARP) WB; IHC; ICC; IP.
Assay Kits SEA279Mu ELISA Kit for Poly ADP Ribose Polymerase (PARP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Poly ADP Ribose Polymerase (PARP) Recombinant Protein Customized Service Offer
Antibodies PAA279Ra01 Polyclonal Antibody to Poly ADP Ribose Polymerase (PARP) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Poly ADP Ribose Polymerase (PARP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Poly ADP Ribose Polymerase (PARP) ELISA Kit Customized Service Offer
  1. "Nucleotide sequence of a full-length cDNA for human fibroblast poly(ADP-ribose) polymerase."Biochem. Biophys. Res. Commun. 148:617-622(1987) [PubMed] [Europe PMC] [Abstract]
  2. "Primary structure of human poly(ADP-ribose) synthetase as deduced from cDNA sequence."J. Biol. Chem. 262:15990-15997(1987) [PubMed] [Europe PMC] [Abstract]
  3. "cDNA sequence, protein structure, and chromosomal location of the human gene for poly(ADP-ribose) polymerase."Proc. Natl. Acad. Sci. U.S.A. 84:8370-8374(1987) [PubMed] [Europe PMC] [Abstract]
  4. "Human nuclear NAD+ ADP-ribosyltransferase(polymerizing): organization of the gene."DNA 8:575-580(1989) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Human poly(ADP-ribose) polymerase gene. Cloning of the promoter region."Eur. J. Biochem. 194:521-526(1990) [PubMed] [Europe PMC] [Abstract]
  8. "Characterization of a putative promoter region of the human poly(ADP-ribose) polymerase gene: structural similarity to that of the DNA polymerase beta gene."Biochem. Biophys. Res. Commun. 167:701-710(1990) [PubMed] [Europe PMC] [Abstract]
  9. , Submitted (DEC-2008) to UniProtKB
  10. "Txk, a member of the non-receptor tyrosine kinase of the Tec family, forms a complex with poly(ADP-ribose) polymerase 1 and elongation factor 1alpha and regulates interferon-gamma gene transcription in Th1 cells."Clin. Exp. Immunol. 147:164-175(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Isolation of a cDNA clone for human NAD+: protein ADP-ribosyltransferase."Eur. J. Cell Biol. 44:302-307(1987) [PubMed] [Europe PMC] [Abstract]
  12. "Molecular cloning of cDNA for human poly(ADP-ribose) polymerase and expression of its gene during HL-60 cell differentiation."Biochem. Biophys. Res. Commun. 146:403-409(1987) [PubMed] [Europe PMC] [Abstract]
  13. ErratumBiochem. Biophys. Res. Commun. 148:1549-1550(1987)
  14. "The second zinc-finger domain of poly(ADP-ribose) polymerase determines specificity for single-stranded breaks in DNA."Proc. Natl. Acad. Sci. U.S.A. 87:2990-2994(1990) [PubMed] [Europe PMC] [Abstract]
  15. "The zinc fingers of human poly(ADP-ribose) polymerase are differentially required for the recognition of DNA breaks and nicks and the consequent enzyme activation. Other structures recognize intact DNA."J. Biol. Chem. 265:21907-21913(1990) [PubMed] [Europe PMC] [Abstract]
  16. "Expression and site-directed mutagenesis of the catalytic domain of human poly(ADP-ribose)polymerase in Escherichia coli. Lysine 893 is critical for activity."J. Biol. Chem. 265:19249-19256(1990) [PubMed] [Europe PMC] [Abstract]
  17. "The human poly(ADP-ribose) polymerase nuclear localization signal is a bipartite element functionally separate from DNA binding and catalytic activity."EMBO J. 11:3263-3269(1992) [PubMed] [Europe PMC] [Abstract]
  18. "Random mutagenesis of the poly(ADP-ribose) polymerase catalytic domain reveals amino acids involved in polymer branching."Biochemistry 36:12147-12154(1997) [PubMed] [Europe PMC] [Abstract]
  19. "Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication."Nucleic Acids Res. 26:1891-1898(1998) [PubMed] [Europe PMC] [Abstract]
  20. "Suppression of the poly(ADP-ribose) polymerase activity by DNA-dependent protein kinase in vitro."Oncogene 18:4616-4625(1999) [PubMed] [Europe PMC] [Abstract]
  21. "Aprataxin, a novel protein that protects against genotoxic stress."Hum. Mol. Genet. 13:1081-1093(2004) [PubMed] [Europe PMC] [Abstract]
  22. "The poly(ADP-ribose) polymerase 1 interacts with Sry and modulates its biological functions."Mol. Cell. Endocrinol. 257:35-46(2006) [PubMed] [Europe PMC] [Abstract]
  23. "A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses."EMBO J. 26:2094-2103(2007) [PubMed] [Europe PMC] [Abstract]
  24. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  25. "Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins."Nature 451:81-85(2008) [PubMed] [Europe PMC] [Abstract]
  26. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  27. "Poly(ADP-ribose) polymerase-1 (PARP-1) transcriptionally regulates angiotensin AT2 receptor (AT2R) and AT2R binding protein (ATBP) genes."Biochem. Pharmacol. 77:1795-1805(2009) [PubMed] [Europe PMC] [Abstract]
  28. "PARP-1 transcriptional activity is regulated by sumoylation upon heat shock."EMBO J. 28:3534-3548(2009) [PubMed] [Europe PMC] [Abstract]
  29. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  30. "Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1."Science 325:1240-1243(2009) [PubMed] [Europe PMC] [Abstract]
  31. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  32. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  33. "Toward a unified nomenclature for mammalian ADP-ribosyltransferases."Trends Biochem. Sci. 35:208-219(2010) [PubMed] [Europe PMC] [Abstract]
  34. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  35. "Poly(ADP-ribose)-dependent regulation of Snail1 protein stability."Oncogene 30:4365-4372(2011) [PubMed] [Europe PMC] [Abstract]
  36. "Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling."PLoS ONE 6:E22595-E22595(2011) [PubMed] [Europe PMC] [Abstract]
  37. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  38. "Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling." Cell 150:533-548(2012) [PubMed] [Europe PMC] [Abstract]
  39. "Systematic analysis of protein pools, isoforms, and modifications affecting turnover and subcellular localization."Mol. Cell. Proteomics 11:M111.013680.01-M111.013680.15(2012) [PubMed] [Europe PMC] [Abstract]
  40. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  41. "BAL1 and its partner E3 ligase, BBAP, link Poly(ADP-ribose) activation, ubiquitylation, and double-strand DNA repair independent of ATM, MDC1, and RNF8."Mol. Cell. Biol. 33:845-857(2013) [PubMed] [Europe PMC] [Abstract]
  42. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  43. "Solution structure of the first ZF-PARP domain, of the BRCT domain and of the WGR domain of human poly(ADP-ribose)polymerase-1."Submitted (APR-2007) to the PDB data bank
  44. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
0.0944s