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Poly ADP Ribose Polymerase (PARP)

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PARP1; ADPRT; ADPRT1; PPOL; pADPRT-1; ADP-ribosyltransferase diphtheria toxin-like 1; NAD(+) ADP-ribosyltransferase 1

Poly ADP Ribose Polymerase (PARP)
CCC A279
HGNC 270
MGI 1340806
PubMed 16123586
RGD 2053
UniProt P09874
Wiki PARP1
is a protein involved in a number of cellular processes involving mainly DNA repair and programmed cell death.RP, a 116 kDa nuclear poly (ADP-ribose) polymerase, appears to be involved in DNA repair in response to environmental stress . This protein can be cleaved by many ICE-like caspases in vitroand is one of the main cleavage targets of caspase-3 in vivo . In human PARP, the cleavage occurs between Asp214 and Gly215, which separates the PARP amino-terminal DNA binding domain (24 kDa) from the carboxy-terminal catalytic domain (89 kDa) .
PARP1 is a chromatin-associated enzyme, poly-ADP ribose polymerase-1, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. PARP1 has a role in repair of single-stranded DNA (ssDNA) breaks.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA279Hu01 Recombinant Poly ADP Ribose Polymerase (PARP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA279Hu01 Polyclonal Antibody to Poly ADP Ribose Polymerase (PARP) WB
MAA279Hu21 Monoclonal Antibody to Poly ADP Ribose Polymerase (PARP) WB
MAA279Hu22 Monoclonal Antibody to Poly ADP Ribose Polymerase (PARP) WB
MAA279Hu23 Monoclonal Antibody to Poly ADP Ribose Polymerase (PARP) WB
MAA279Hu24 Monoclonal Antibody to Poly ADP Ribose Polymerase (PARP) WB
MAA279Hu25 Monoclonal Antibody to Poly ADP Ribose Polymerase (PARP) WB
Assay Kits SEA279Hu ELISA Kit for Poly ADP Ribose Polymerase (PARP) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA279Hu CLIA Kit for Poly ADP Ribose Polymerase (PARP) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA279Mu01 Recombinant Poly ADP Ribose Polymerase (PARP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA279Mu01 Polyclonal Antibody to Poly ADP Ribose Polymerase (PARP) WB; IHC; FCM
Assay Kits SEA279Mu ELISA Kit for Poly ADP Ribose Polymerase (PARP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Poly ADP Ribose Polymerase (PARP) Recombinant Protein Customized Service Offer
Antibodies PAA279Ra01 Polyclonal Antibody to Poly ADP Ribose Polymerase (PARP) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Poly ADP Ribose Polymerase (PARP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Poly ADP Ribose Polymerase (PARP) ELISA Kit Customized Service Offer
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  9. , Submitted (DEC-2008) to UniProtKB
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  28. "PARP-1 transcriptional activity is regulated by sumoylation upon heat shock."EMBO J. 28:3534-3548(2009) [PubMed] [Europe PMC] [Abstract]
  29. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
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  31. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  32. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
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  42. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
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