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Apolipoprotein C1 (APOC1)

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Apo-C1; Truncated apolipoprotein C-I

Apolipoprotein C1 (APOC1)
CCC A252
HGNC 607
MGI 88053
PubMed 11723061
RGD 2134
UniProt P02654
Wiki APOC1

Apolipoprotein C1 is a lipoprotein with a length of 57 amino acids normally found in plasma and responsible for the activation of esterified lechitin cholesterol with an important role in the exchange of esterified cholesterol between lipoproteins and in removal of cholesterol from tissues.

Its main function is inhibition of CETP, probably by altering the electric charge of HDL molecules. during fasting (like other apolipoprotein C) is found primarily within HDL, meanwhile after a meal it is found within the surface of other lipoproteins. in contrast when proteins rich in triglycerides like chylomicrons and VLDL are broken down this apoprotein is transferred again to the HDL.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA252Hu01 Recombinant Apolipoprotein C1 (APOC1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA252Hu02 Recombinant Apolipoprotein C1 (APOC1) Positive Control; Immunogen; SDS-PAGE; WB.
APA252Hu01 Active Apolipoprotein C1 (APOC1) Cell culture; Activity Assays.
APA252Hu02 Active Apolipoprotein C1 (APOC1) Cell culture; Activity Assays.
Antibodies PAA252Hu01 Polyclonal Antibody to Apolipoprotein C1 (APOC1) WB; IHC; ICC/IF; FCM
MAA252Hu22 Monoclonal Antibody to Apolipoprotein C1 (APOC1) WB; IHC; ICC; IP.
LAA252Hu71 Biotin-Linked Polyclonal Antibody to Apolipoprotein C1 (APOC1) WB; IHC; ICC.
MAA252Hu21 Monoclonal Antibody to Apolipoprotein C1 (APOC1) WB
MAA252Hu23 Monoclonal Antibody to Apolipoprotein C1 (APOC1) WB; IHC; ICC; IP.
PAA252Hu02 Polyclonal Antibody to Apolipoprotein C1 (APOC1) WB; IHC; ICC; IP.
Assay Kits SEA252Hu ELISA Kit for Apolipoprotein C1 (APOC1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA252Mu01 Recombinant Apolipoprotein C1 (APOC1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA252Mu02 Recombinant Apolipoprotein C1 (APOC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA252Mu01 Polyclonal Antibody to Apolipoprotein C1 (APOC1) WB; IHC; ICC; IP.
PAA252Mu02 Polyclonal Antibody to Apolipoprotein C1 (APOC1) WB; IHC; ICC; IP.
MAA252Mu21 Monoclonal Antibody to Apolipoprotein C1 (APOC1) WB; IHC; ICC; IP.
MAA252Mu24 Monoclonal Antibody to Apolipoprotein C1 (APOC1) WB; IHC; ICC; IP.
MAA252Mu25 Monoclonal Antibody to Apolipoprotein C1 (APOC1) WB; IHC; ICC; IP.
MAA252Mu27 Monoclonal Antibody to Apolipoprotein C1 (APOC1) WB; IHC; ICC; IP.
Assay Kits SEA252Mu ELISA Kit for Apolipoprotein C1 (APOC1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA252Ra01 Recombinant Apolipoprotein C1 (APOC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA252Ra01 Polyclonal Antibody to Apolipoprotein C1 (APOC1) WB; IHC; ICC; IP.
Assay Kits SEA252Ra ELISA Kit for Apolipoprotein C1 (APOC1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA252Rb01 Recombinant Apolipoprotein C1 (APOC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA252Rb51 Polyclonal Antibody to Apolipoprotein C1 (APOC1) WB; IHC; ICC; IP.
PAA252Rb01 Polyclonal Antibody to Apolipoprotein C1 (APOC1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Apolipoprotein C1 (APOC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Apolipoprotein C1 (APOC1) ELISA Kit Customized Service Offer

Organism species: Rhesus monkey (Simian)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Apolipoprotein C1 (APOC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Apolipoprotein C1 (APOC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Apolipoprotein C1 (APOC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Apolipoprotein C1 (APOC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Apolipoprotein C1 (APOC1) ELISA Kit Customized Service Offer

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA252Ca01 Recombinant Apolipoprotein C1 (APOC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA252Ca01 Polyclonal Antibody to Apolipoprotein C1 (APOC1) WB; IHC
Assay Kits n/a CLIA Kit for Apolipoprotein C1 (APOC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Apolipoprotein C1 (APOC1) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA252Bo01 Recombinant Apolipoprotein C1 (APOC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA252Bo01 Polyclonal Antibody to Apolipoprotein C1 (APOC1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Apolipoprotein C1 (APOC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Apolipoprotein C1 (APOC1) ELISA Kit Customized Service Offer
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  2. "Two copies of the human apolipoprotein C-I gene are linked closely to the apolipoprotein E gene."J. Biol. Chem. 263:7277-7286(1988) [PubMed] [Europe PMC] [Abstract]
  3. "Sequencing of 42kb of the APO E-C2 gene cluster reveals a new gene: PEREC1."DNA Seq. 9:89-100(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Isolation and characterisation of a cDNA clone for human apolipoprotein CI and assignment of the gene to chromosome 19."Hum. Genet. 69:345-349(1985) [PubMed] [Europe PMC] [Abstract]
  7. "The complete amino acid sequence of C-I (apoLp-Ser), an apolipoprotein from human very low density lipoproteins."J. Biol. Chem. 250:182-190(1975) [PubMed] [Europe PMC] [Abstract]
  8. "The primary structure of apolipoprotein-serine."J. Biol. Chem. 249:5308-5313(1974) [PubMed] [Europe PMC] [Abstract]
  9. "Exact localization of the familial dysbetalipoproteinemia associated HpaI restriction site in the promoter region of the APOC1 gene."Biochem. Biophys. Res. Commun. 152:1282-1288(1988) [PubMed] [Europe PMC] [Abstract]
  10. "Apolipoprotein C-I binds free fatty acids and reduces their intracellular esterification."J. Lipid Res. 48:1353-1361(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Higher primates, but not New World monkeys, have a duplicate set of enhancers flanking their apoC-I genes."Comp. Biochem. Physiol. 11:45-48(2014) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  13. "Conformation of two peptides corresponding to human apolipoprotein C-I residues 7-24 and 35-53 in the presence of sodium dodecyl sulfate by CD and NMR spectroscopy."Biochemistry 34:7401-7408(1995) [PubMed] [Europe PMC] [Abstract]
  14. "Conformational studies of the N-terminal lipid-associating domain of human apolipoprotein C-I by CD and 1H NMR spectroscopy."Protein Sci. 6:1858-1868(1997) [PubMed] [Europe PMC] [Abstract]
  15. "Conformation of human apolipoprotein C-I in a lipid-mimetic environment determined by CD and NMR spectroscopy."Biochemistry 38:14475-14484(1999) [PubMed] [Europe PMC] [Abstract]
  16. "Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."Nat. Genet. 22:239-247(1999) [PubMed] [Europe PMC] [Abstract]
  17. "A functional polymorphism of apolipoprotein C1 detected by mass spectrometry."FEBS J. 273:4707-4715(2006) [PubMed] [Europe PMC] [Abstract]