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Alpha-1-Microglobulin (a1M)

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AMBP; UTI; HCP; EDC1; HI30; IATIL; ITILC; ITI; ITIL; Alpha 1 Microglobulin/Bikunin Precursor; Growth-inhibiting protein 19; Uristatin; Uronic-Acid-Rich Protein; Trypstatin

Alpha-1-Microglobulin (a1M)
CCC A217
HGNC 453
MGI 88002
PubMed 15256311
RGD 2102
UniProt P02760
Wiki AMBP

Alpha-1-microglobulin (A1M), also known as protein HC (for Heterogeneous Charge), is a low molecular weight protein component of plasma first discovered in pathological human urine. It is a member of the lipocalin superfamily. Although much is now known of its structure and properties, the function and physiological role of A1M remains unclear, although evidence suggests that it functions in the regulation of the immune system. A1M is known to exist in both a free form and complexed to other macromolecules: immunoglobulin A (IgA) in humans and alpha-1-inhibitor-3 in the rat. Free A1M is a monomeric protein composed of one 188 residue polypeptide and contains three cysteines, two of which (residues 75 and 173) form a conserved intra-molecular disulphide link.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA217Hu01 Recombinant Alpha-1-Microglobulin (a1M) Positive Control; Immunogen; SDS-PAGE; WB.
EPA217Hu61 Eukaryotic Alpha-1-Microglobulin (a1M) Positive Control; Immunogen; SDS-PAGE; WB.
EPA217Hu62 Eukaryotic Alpha-1-Microglobulin (a1M) Positive Control; Immunogen; SDS-PAGE; WB.
APA217Hu61 Active Alpha-1-Microglobulin (a1M) Cell culture; Activity Assays.
APA217Hu62 Active Alpha-1-Microglobulin (a1M) Cell culture; Activity Assays.
Antibodies PAA217Hu01 Polyclonal Antibody to Alpha-1-Microglobulin (a1M) WB
MAA217Hu22 Monoclonal Antibody to Alpha-1-Microglobulin (a1M) WB; IHC; ICC; IP.
LAA217Hu71 Biotin-Linked Polyclonal Antibody to Alpha-1-Microglobulin (a1M) WB; IHC; ICC.
Assay Kits SEA217Hu ELISA Kit for Alpha-1-Microglobulin (a1M) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA217Hu CLIA Kit for Alpha-1-Microglobulin (a1M) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA217Mu01 Recombinant Alpha-1-Microglobulin (a1M) Positive Control; Immunogen; SDS-PAGE; WB.
RPA217Mu02 Recombinant Alpha-1-Microglobulin (a1M) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA217Mu01 Polyclonal Antibody to Alpha-1-Microglobulin (a1M) WB; IHC; ICC; IP.
LAA217Mu81 FITC-Linked Polyclonal Antibody to Alpha-1-Microglobulin (a1M) WB; IHC; ICC; IF.
LAA217Mu71 Biotin-Linked Polyclonal Antibody to Alpha-1-Microglobulin (a1M) WB; IHC; ICC.
PAA217Mu02 Polyclonal Antibody to Alpha-1-Microglobulin (a1M) WB; IHC; ICC; IP.
Assay Kits SEA217Mu ELISA Kit for Alpha-1-Microglobulin (a1M) Enzyme-linked immunosorbent assay for Antigen Detection.
CEA217Mu ELISA Kit for Alpha-1-Microglobulin (a1M) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA217Ra01 Recombinant Alpha-1-Microglobulin (a1M) Positive Control; Immunogen; SDS-PAGE; WB.
RPA217Ra02 Recombinant Alpha-1-Microglobulin (a1M) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA217Ra01 Polyclonal Antibody to Alpha-1-Microglobulin (a1M) WB; IHC; ICC; IP.
LAA217Ra81 FITC-Linked Polyclonal Antibody to Alpha-1-Microglobulin (a1M) WB; IHC; ICC; IF.
LAA217Ra71 Biotin-Linked Polyclonal Antibody to Alpha-1-Microglobulin (a1M) WB; IHC; ICC.
PAA217Ra02 Polyclonal Antibody to Alpha-1-Microglobulin (a1M) WB; IHC; ICC; IP.
Assay Kits SEA217Ra ELISA Kit for Alpha-1-Microglobulin (a1M) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Cavia (Guinea pig )

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA217Gu01 Recombinant Alpha-1-Microglobulin (a1M) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA217Gu01 Polyclonal Antibody to Alpha-1-Microglobulin (a1M) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Alpha-1-Microglobulin (a1M) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alpha-1-Microglobulin (a1M) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA217Po01 Recombinant Alpha-1-Microglobulin (a1M) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA217Po01 Polyclonal Antibody to Alpha-1-Microglobulin (a1M) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Alpha-1-Microglobulin (a1M) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alpha-1-Microglobulin (a1M) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA217Bo01 Recombinant Alpha-1-Microglobulin (a1M) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA217Bo01 Polyclonal Antibody to Alpha-1-Microglobulin (a1M) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Alpha-1-Microglobulin (a1M) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alpha-1-Microglobulin (a1M) ELISA Kit Customized Service Offer
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  2. "The mRNA for a proteinase inhibitor related to the HI-30 domain of inter-alpha-trypsin inhibitor also encodes alpha-1-microglobulin (protein HC)."Nucleic Acids Res. 14:7839-7850(1986) [PubMed] [Europe PMC] [Abstract]
  3. "Structure of the human alpha 1-microglobulin-bikunin gene."Biol. Chem. Hoppe-Seyler 371:1185-1196(1990) [PubMed] [Europe PMC] [Abstract]
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  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The complete amino acid sequence of human complex-forming glycoprotein heterogeneous in charge (protein HC) from one individual."Arch. Biochem. Biophys. 228:544-554(1984) [PubMed] [Europe PMC] [Abstract]
  9. "Complete amino acid sequence of human alpha 1-microglobulin."Biochem. Biophys. Res. Commun. 98:997-1001(1981) [PubMed] [Europe PMC] [Abstract]
  10. "Human protein HC displays variability in its carboxyl-terminal amino acid sequence."FEBS Lett. 144:349-353(1982)
  11. "Location of a novel type of interpolypeptide chain linkage in the human protein HC-IgA complex (HC-IgA) and identification of a heterogeneous chromophore associated with the complex."J. Biol. Chem. 269:384-389(1994) [PubMed] [Europe PMC] [Abstract]
  12. "Human inter-alpha-trypsin inhibitor: localization of the Kunitz-type domains in the N-terminal part of the molecule and their release by a trypsin-like proteinase."Biol. Chem. Hoppe-Seyler 366:479-483(1985) [PubMed] [Europe PMC] [Abstract]
  13. "Cancer-related urinary proteinase inhibitor, EDC1: a new method for its isolation and evidence for multiple forms."J. Cell. Biochem. 50:227-236(1992) [PubMed] [Europe PMC] [Abstract]
  14. "Chondroitin 4-sulfate covalently cross-links the chains of the human blood protein pre-alpha-inhibitor."J. Biol. Chem. 266:747-751(1991) [PubMed] [Europe PMC] [Abstract]
  15. "Presence of the protein-glycosaminoglycan-protein covalent cross-link in the inter-alpha-inhibitor-related proteinase inhibitor heavy chain 2/bikunin."J. Biol. Chem. 268:8711-8716(1993) [PubMed] [Europe PMC] [Abstract]
  16. "Characterization of uronic-acid-rich inhibitor of calcium oxalate crystallization isolated from rat urine."Urol. Res. 23:95-101(1995) [PubMed] [Europe PMC] [Abstract]
  17. "Chondroitin sulphate covalently cross-links the three polypeptide chains of inter-alpha-trypsin inhibitor."Eur. J. Biochem. 221:881-888(1994) [PubMed] [Europe PMC] [Abstract]
  18. "Kunitz-type proteinase inhibitors derived by limited proteolysis of the inter-alpha-trypsin inhibitor, V. Attachments of carbohydrates in the human urinary trypsin inhibitor isolated by affinity chromatography."Hoppe-Seyler's Z. Physiol. Chem. 362:1357-1362(1981) [PubMed] [Europe PMC] [Abstract]
  19. "The reactive site of human inter-alpha-trypsin inhibitor is in the amino-terminal half of the protein."Biol. Chem. Hoppe-Seyler 366:19-21(1985) [PubMed] [Europe PMC] [Abstract]
  20. "Location and characterization of the three carbohydrate prosthetic groups of human protein HC."FEBS Lett. 266:167-170(1990) [PubMed] [Europe PMC] [Abstract]
  21. "The protein HC chromophore is linked to the cysteine residue at position 34 of the polypeptide chain by a reduction-resistant bond and causes the charge heterogeneity of protein HC."J. Biol. Chem. 266:15758-15763(1991) [PubMed] [Europe PMC] [Abstract]
  22. "Alpha1-microglobulin chromophores are located to three lysine residues semiburied in the lipocalin pocket and associated with a novel lipophilic compound."Protein Sci. 8:2611-2620(1999) [PubMed] [Europe PMC] [Abstract]
  23. "Human alpha-1-microglobulin is covalently bound to kynurenine-derived chromophores."J. Biol. Chem. 279:51033-51041(2004) [PubMed] [Europe PMC] [Abstract]
  24. "The ORF3 protein of hepatitis E virus interacts with liver-specific alpha1-microglobulin and its precursor alpha1-microglobulin/bikunin precursor (AMBP) and expedites their export from the hepatocyte."J. Biol. Chem. 279:29308-29319(2004) [PubMed] [Europe PMC] [Abstract]
  25. "The 41-amino-acid C-terminal region of the hepatitis E virus ORF3 protein interacts with bikunin, a Kunitz-type serine protease inhibitor."J. Virol. 79:12081-12087(2005) [PubMed] [Europe PMC] [Abstract]
  26. "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
  27. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  28. "The crystal structure of bikunin from the inter-alpha-inhibitor complex: a serine protease inhibitor with two Kunitz domains."J. Mol. Biol. 276:955-966(1998) [PubMed] [Europe PMC] [Abstract]
  29. "Alpha(1)-microglobulin: a yellow-brown lipocalin."Biochim. Biophys. Acta 1482:172-184(2000) [PubMed] [Europe PMC] [Abstract]